Parallel and Automated Library Synthesis of 2‐Long Alkyl Chain Benzoazoles and Azole[4,5‐b]pyridines under Microwave Irradiation.

Abstract

Imidazole derivatives R 0190Parallel and Automated Library Synthesis of 2-Long Alkyl Chain Benzoazoles and Azole[4,5-b]pyridines under Microwave Irradiation. -A 40-membered library of pharmacologically interesting anellated imidazoles and oxazoles (III), (V) and (VII) is prepared. In addition, derivatives with long alkyl chains may be useful as corrosion inhibitors for oil field applications. -(MARTINEZ-PALOU*, R.; ZEPEDA, L. G.; HOEPFL, H.; MONTOYA, A.; GUZMAN-LUCERO, D. J.; GUZMAN, J.; Mol. Diversity 9 (2005) 4, 361-369; Inst. Mex. Pet., Gerencia Catal. Mat., Eje Cent. Lazaro Cardenas, 07730 Mexico, Mex.; Eng.) -Nuesgen 21-130

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

“…The benzimidazole fragment is a frequent motif in recent publications devoted to drug design and molecular diversity oriented synthesis [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ]. Fused polycyclic derivatives of benzimidazo[1,2- a ] pyrimidines are often cited as anti-cancer and cytotoxic agents [ 10 , 11 , 12 , 13 , 14 ].…”