Paralisia do nervo ulnar na lepra sem alterações cutâneas: biópsia do ramo superficial do nervo ulnar na mão

Freitas, Marcos R. G. de; Nascimento, Osvaldo Jm; Drago, Márcio J.; Freitas, Andrea R. de; Hahn, Myrian D.

doi:10.1590/s0004-282x1998000400011

Cited by 12 publications

(5 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mononeuritis is the most common presentation of the neuritic form of leprosy and the ulnar nerve is the most affected. We had shown that in these cases the biopsy of the superficial ulnar nerve in the hand is the best way to diagnose leprosy 14 .…”

Section: Discussionmentioning

confidence: 99%

Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases

Freitas

Nascimento

Quaglino

et al. 2003

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

-Leprosy is one of the most common diseases of the peripheral nerves. In some cases there is only neural involvement without skin changes (neuritic form). The neuropathy has often a distal stocking and glove distribution with thermal and pinprick anesthesia and preservation of proprioception. There is no weakness, the tendon reflexes may be preserved and sometimes the nerves are thickened. We reported 17 patients with a predominantly small-fiber polyneuropathy due to leprosy. All patients had distal temperature and pain anesthesia with different individual variations. The tendon reflexes were normal in seven patients and in eight there was thickening of the nerves. The nerve conduction was normal in three patients. Sural nerve biopsy consisted of: 1) inflammatory infiltrates, 2) vacuolated "foamy" cells, 3) fibrosis of endoneurium, perineurium, and epineurium, 4) partial or total loss of nerve fibers, 5) large number of bacilli. We concluded that in countries where leprosy is frequent, nerve biopsy is an obligatory procedure in patients with predominantly small-fiber polyneuropathy.KEY WORDS: leprosy, pure neuritic leprosy, small-fiber polyneuropathy, peripheral neuropathy, nerve biopsy. Polineuropatia de fibras-finas devido a lepra sem alterações cutâneas: estudo de 17 casosRESUMO -Em vários países tropicais a lepra constitui uma das principais causas de acometimento dos nervos periféricos. Em alguns casos somente os nervos são comprometidos, sem acometimento cutâneo (forma neurítica pura). Na polineuropatia há anestesia térmica e dolorosa com preservação da propriocepção. A força é normal, os reflexos profundos podem estar preservados e os nervos nem sempre estão espessados. Relatamos 17 pacientes com este tipo de polineuropatia. Todos tinham variados níveis de anestesia térmica e dolorosa distal nos membros. Os reflexos profundos estavam normais em sete pacientes e em oito havia leve espessamento dos nervos. A neurocondução foi normal em três pacientes. A biópsia do nervo sural revelou: 1) extenso infiltrado inflamatório, 2) células vacuoladas, 3) fibrose do endoneuro, perineuro e epineuro, 4) perda total ou parcial de fibras nervosas, 5) presença de bacilos da lepra. Concluímos que somente a biópsia de nervo permite o diagnóstico de pacientes com polineuropatia com acometimento predominante de pequenas fibras devida a lepra. PALAVRAS-CHAVE: lepra, lepra neurítica pura, polineuropatia de fibras finas, neuropatia periférica, biópsia de nervo.

show abstract

Section: Discussionmentioning

confidence: 99%

Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases

Freitas

Nascimento

Quaglino

et al. 2003

Arq. Neuro-Psiquiatr.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The DCBU has been suggested as a site of biopsy for diagnostic purposes ( Chimelli et al, 1997 ; Freitas et al, 1998 ) , particularly in cases under investigation for a leprosy neuropathy. This study aims at describing DCBU microscopic aspects and the histometric parameters of its myelinated and unmyelinated fibers.…”

Section: Introductionmentioning

confidence: 99%

Dorsal cutaneous branch of the ulnar nerve: a light and electron microscopy histometric study

Oliveira¹,

Fazan

Marques³

et al. 2011

J Peripheral Nervous Sys

View full text Add to dashboard Cite

This study describes the normal morphology and morphometry of the dorsal cutaneous branch of the ulnar nerve (DCBU) in humans. Fourteen nerves of eight donors were prepared by conventional techniques for paraffin and epoxy resin embedding. Semiautomatic morphometric analysis was performed by means of specific computer software. Histograms of the myelinated and unmyelinated fiber population and the G-ratio distribution of fibers were plotted. Myelinated fiber density per nerve varied from 5,910 to 10,166 fibers/mm(2) , with an average of 8,170 ± 393 fibers/mm(2) . The distribution was bimodal with peaks at 4.0 and 9.5 µm. Unmyelinated fiber density per nerve varied from 50,985 to 127,108, with an average of 78,474 ± 6,610 fibers/mm(2) , with a unimodal distribution displaying a peak at 0.8 µm. This study thus adds information about the fascicles and myelinated and unmyelinated fibers of DCBU nerves in normal people, which may be useful in further studies concerning ulnar nerve neuropathies, mainly leprosy neuropathy.

show abstract

“…Pure neuritic leprosy is a subtype of leprosy that represents up to 8% of all leprosy cases [9]. Nerve biopsy is the diagnostic gold standard, with a reported sensitivity of 33.3-75.9% of cases [36][37][38]. Pure neuritic leprosy presents as an isolated peripheral neuropathy.…”

Section: Neuritic Leprosymentioning

confidence: 99%

Neurosurgical Intervention for Nerve and Muscle Biopsies

Mohamed,

Caussat,

Mouhawasse

et al. 2024

Preprint

View full text Add to dashboard Cite

(1) Background: Neurologic and musculoskeletal diseases represent a considerable portion of the underlying etiologies responsible for the widely prevalent symptoms of pain, weakens, numbness, and paresthesia. Because of the subjective and often nonspecific nature of these symptoms, different diagnostic modalities have been explored and utilized.; (2) Methods: Literature review; (3) Results: Nerve and muscle biopsy remains the gold standard for diagnosing many of the responsible neurological and musculoskeletal conditions. However, the need for invasive tissue sampling is diminishing as more investigations explore alternative diagnostic modalities. Because of this, it is important to explore the current role of neurosurgical intervention for nerve and muscle biopsies and its current relevance in the diagnostic landscape of neurological and musculoskeletal disorders. With consideration of the role of nerve and muscle biopsy, it is also important to explore innovations and emerging techniques for conducting these procedures. This review explores the indications and emerging techniques for neurological intervention for nerve and muscle biopsies; (4) Conclusions: The role of neurosurgical intervention for nerve and muscle biopsy remains relevant in diagnosing many neurological and musculoskeletal disorders. Biopsy is especially relevant as a supportive point of evidence for diagnosis in atypical cases. Additionally, emerging techniques have been explored to guide diagnostics and biopsy, conduct less invasive biopsies, and reduce risks of worsening neurologic function and other symptoms secondary to biopsy.

show abstract

Paralisia do nervo ulnar na lepra sem alterações cutâneas: biópsia do ramo superficial do nervo ulnar na mão

Cited by 12 publications

References 11 publications

Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases

Small-fiber polyneuropathy in leprosy without skin changes: study of 17 cases

Dorsal cutaneous branch of the ulnar nerve: a light and electron microscopy histometric study

Neurosurgical Intervention for Nerve and Muscle Biopsies

Contact Info

Product

Resources

About