Parahydrogen-based NMR signal amplification by reversible exchange (SABRE): Recent advances and applications

MATRESHCA: Microtesla Apparatus for Transfer of Resonance Enhancement of Spin Hyperpolarization via Chemical Exchange and Addition

“…We envision that the relatively large chamber of the solenoid magnet can, in principle, enable the use of a substantially larger reaction chamber, and sample sizes over 1 L can, in principle, be accommodated. At the same time, the small scale of polarization in 5 mm NMR tubes reported here is large enough to produce a dose of the 13 C contrast agent for its utility in mice and rats. ,, We also envision that other biologically relevant molecules can be hyperpolarized using the reported hyperpolarization via SABRE-SHEATH approach and pulsed-SABRE-SHEATH approaches because all enabling functionalities are indeed available in the reported hyperpolarizer. , Moreover, while the feasibility demonstrations of hyperpolarization processes have been performed using a large (ca. 10 L size) aluminum cylinder containing compressed p-H 2 gas, the reported device can potentially utilize p-H 2 gas packed in cheap and disposable pressurized aluminum cans, an approach that may further reduce the cost and complexity of hyperpolarizer operation, especially in the proximity of MRI scanners.…”

“…24,25,56 We also envision that other biologically relevant molecules can be hyperpolarized using the reported hyperpolarization via SABRE-SHEATH approach and pulsed-SABRE-SHEATH approaches because all enabling functionalities are indeed available in the reported hyperpolarizer. 35,80 Moreover, while the feasibility demonstrations of hyperpolarization processes have been performed using a large (ca. 10 L size) aluminum cylinder 60 containing compressed p-H 2 gas, the reported device can potentially utilize p-H 2 gas packed in cheap and disposable pressurized aluminum cans, 81 an approach that may further reduce the cost and complexity of hyperpolarizer operation, especially in the proximity of MRI scanners.…”

“…15−21 The resulting p-H 2 -hyperpolarized substrates can be employed for in vivo imaging 6,22−29 and other applications, e.g., reaction monitoring. 30−33 The two major groups of p-H 2 -based hyperpolarization techniques are non-hydrogenative signal amplification by reversible exchange (SABRE) 34,35 and hydrogenative PHIP. 8,9,36 SABRE technique is based on simultaneous chemical exchange of a p-H 2 and to-be-hyperpolarized molecule on a metal center.…”

“…The two major groups of p-H 2 -based hyperpolarization techniques are non-hydrogenative signal amplification by reversible exchange (SABRE) , and hydrogenative PHIP. ,, SABRE technique is based on simultaneous chemical exchange of a p-H 2 and to-be-hyperpolarized molecule on a metal center . Both methods rely on p-H 2 gas as the source of spin order .…”

Parahydrogen‐Induced Polarization of 14N Nuclei

“…[1] The most widely used hyperpolarization techniques for solution-state NMR are dissolution dynamic nuclear polarization (dDNP), [2,3] parahydrogen-induced polarization (PHIP), [4][5][6] and signal amplification by reversible exchange (SABRE). [7][8][9] The latter two techniques use parahydrogen (p-H 2 )-the singlet nuclear spin isomer of H 2 -as a source of hyperpolarization. PHIP typically exploits pairwise addition of two H atoms from a p-H 2 molecule to the same substrate molecule using either homogeneous [10] or heterogeneous [11,12] hydrogenation catalysis, while in SABRE both p-H 2 and substrate molecules engage in reversible exchange with a metal complex, and polarization is transferred from p-H 2 -derived hydrides to the substrate nuclei within the complex.…”