Paragangliomas of the Neck

Bishop, Gerri; Urist, Marshall M.; Gammal, T el; Peters, Glenn E.; Maddox, William A.

doi:10.1001/archsurg.1992.01420120075014

Cited by 50 publications

(35 citation statements)

References 19 publications

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“…The paraganglia of the neck and upper chest area (e.g. carotid or aortic bodies) are distinct from paravertebral or sympathetic outflow paraganglia; they are autonomic system chemoreceptors rather than neuroendocrine cells, and they do not secrete catecholamines (Lack et al 1979, Bishop et al 1992.…”

Section: Discussionmentioning

confidence: 99%

“…In clinical practice, the diagnostic and therapeutic issues raised with paragangliomas of the neck area (also referred to as 'chemodectomas' by some authors) (Lack et al 1979, Merino & Livolsi 1981, Parry et al 1982, Bishop et al 1992 are quite different from those with tumors capable of catecholamine hypersecretion. Accordingly, intraabdominal, sympathetic system lesions are usually discussed separately; both adrenal and extra-adrenal tumors are often combined in such reviews, perhaps to allow examination of larger samples of this rare disease.…”

Section: Discussionmentioning

confidence: 99%

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Clinical outcome of 50 patients with malignant abdominal paragangliomas and malignant pheochromocytomas

Vassilopoulou‐Sellin¹

1998

Endocrine Related Cancer

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Background: Tumors of the paraganglionic system represent a distinct, albeit uncommon, clinical entity characterized by catecholamine hypersecretion and hemodynamic instability; initial pathologic examination often cannot predict benign vs malignant behavior. An analysis of the clinical outcome of patients with known malignant tumors may serve to enhance the initial evaluation and therapeutic plan of all patients presenting with pheochromocytoma or paraganglioma. Results: Among the 30 patients with paraganglioma, 73% were men, and 90% were younger than 50 years at the time of diagnosis. Sixteen patients have remained alive with persistent disease 0.2 to 25 years after initial diagnosis while eight patients died of their disease within 0.8 to 32 years. Regional recurrence and skeletal metastases were the most prominent events. Among the 20 patients with pheochromocytoma, 60% were men and 70% were younger than 50 years at the time of diagnosis. Ten patients have remained alive with persistent disease 0.8 to 20 years after initial diagnosis while five patients died of their disease within 1.5 to 39 years. Hypertension was a prominent presenting feature and regional recurrence was the most frequent pattern of treatment failure.Conclusions: Important clinical differences distinguish adrenal pheochromocytomas from extraadrenal, abdominal paragangliomas. Patients with paragangliomas are, as a group, younger men, more likely to have malignant lesions and a more aggressive clinical course. Patients with malignant pheochromocytomas usually present with hypertension, are somewhat older, and have less aggresEndocrine-Related Cancer (1998) 5 59-68 sive disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical outcome of 50 patients with malignant abdominal paragangliomas and malignant pheochromocytomas

Vassilopoulou‐Sellin¹

1998

Endocrine Related Cancer

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“…They are highly vascularized tumors involving the walls of the blood vessels or specific nerves [3][4][5]. In the larynx they arise from superior or inferior laryngeal paraganglia and are seen in the supraglottis in 90 % of the cases [6].…”

Section: Introductionmentioning

confidence: 99%

Laryngeal Paraganglioma: A Rare Clinical Entity Managed by Supraselective Embolization and Lateral Pharygotomy

Naik

Shenoy

Chavan

et al. 2012

Indian J Otolaryngol Head Neck Surg

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Laryngeal paragangliomas are benign slow growing tumors with symptoms resembling squamous cell carcinoma. Hoarseness or dysphasia are the commonest presenting symptoms and usually it presents as an submucosal mass on laryngoscopy. Ninety percentage of these tumors occur in the supraglottic larynx and the rest in the glottis and the subglottic region. Functional activity is seen in a few (2.9 %), none are associated with paraneoplastic syndromes. A 35-year-old male presented to us with hoarseness of voice since 4 months duration. Contrast arteriography demonstrated that the left superior thyroid artery supplied [80 % of the blood supply to the laryngeal mass. Supraselective embolization was done from the right femorals under local anaesthesia and sedation which was uneventfull. The tumor was excised from lateral pharyngotomy approach with an partial laryngectomy procedure. Microscopy and immune-histochemistry confirmed it to be paraganglioma. Complete surgical resection or partial laryngectomy with meticulous dissection of surrounding tissues and preservation of neurovascular structures gives an excellent prognosis as far as oncological clearance is concerned. Malignant paragangliomas of the larynx are rare and an major meta-analysis is necessary to provide a true biological behaviour of this tumor.

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“…Среди параганглиом головы и шеи каро-тидная хемодектома занимает одну из ведущих позиций по распространённости [3]. Наиболее часто встречается в возрасте от 50 до 70 лет, распространённость у женщин несколько выше, чем у мужчин [4].…”

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“…Данная опухоль в большинстве случаев ха-рактеризуется доброкачественным течением [3]. Малигнизация происходит менее чем в 10% случаев [5], малигнизированная хемодектома способна к метастазированию [6].…”

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Current conception of carotid chemodectoma and efficiency of its treatment methods

et al. 2017

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The review presents current data from foreign studies of a rare tumor — carotid chemodectoma, particularly, about its prevalence, classification, clinical presentation, applicability of different diagnostics methods, and also on efficiency of treatment of this disease and complications developing after it in terms of described clinical cases. Search for relevant sources was carried out in Medline, US National Library of Medicine, Elibrary systems, in Cochrane Library and peer-reviewed scientific journals. A total of 26 studies were found, 22 of them were included in the review. Carotid chemodectoma is most often characterized by benign course, but, because of its scarce clinical presentation, specific examination methods are required for its accurate diagnosis. Surgical resection is usually used for the treatment of carotid chemodectoma, and in case of contraindications for the surgery, radiotherapy is applied (as a palliative method). The most widespread complications after surgical treatment are cranial nerve damage, intraoperative bleeding and ischemic stroke. Several cases were described in literature, when scientists from different countries (USA, Korea) attempted to decrease risk of complications by use of preoperational embolization, but that led to new complications, particularly, to migration of embolic material. At the same time, scientists from Netherlands noted some decrease of the number of postoperative complications when craniocaudal method was used. To date the only effective method of treatment of carotid chemodectoma is still surgical resection, but it cannot be used in a broad variety of cases. Moreover, the world surgical practice has no effective techniques for prevention of different complications occurring in postoperative period, that reduces possibilities of successful patients’ recovery. Therefore, to decrease the rate of postoperative complications and to increase patients survival rate further studies are required.

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Paragangliomas of the Neck

Cited by 50 publications

References 19 publications

Clinical outcome of 50 patients with malignant abdominal paragangliomas and malignant pheochromocytomas

Clinical outcome of 50 patients with malignant abdominal paragangliomas and malignant pheochromocytomas

Laryngeal Paraganglioma: A Rare Clinical Entity Managed by Supraselective Embolization and Lateral Pharygotomy

Current conception of carotid chemodectoma and efficiency of its treatment methods

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