Paragangliomas—A decade of clinical experience

Somasundar, Ponnandai; Krouse, Robert S.; Hostetter, R.; Vaughan, Richard; Covey, Thomas H.

doi:10.1002/1096-9098(200008)74:4<286::aid-jso9>3.3.co;2-3

Cited by 24 publications

(29 citation statements)

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“…They originate in the carotid body, organ of Zuckerkandl, and other unnamed paraganglia of the autonomic nervous system [5]. Most paragangliomas (75%) occur adjacent to the aorta in the organ of Zuckerkandl, with the highest incidence typically near the origin of the inferior mesenteric artery [6].…”

Section: Discussionmentioning

confidence: 99%

Intraoperative diagnosis of a functional paraganglioma presenting as a gastrointestinal stromal cell tumor (GIST)

Lowenthal

Sadow

Raut

et al. 2009

Journal of Clinical Anesthesia

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Section: Discussionmentioning

confidence: 99%

Intraoperative diagnosis of a functional paraganglioma presenting as a gastrointestinal stromal cell tumor (GIST)

Lowenthal

Sadow

Raut

et al. 2009

Journal of Clinical Anesthesia

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“…The prevalence is higher in males and the average age upon diagnosis is 30 years [1]. Rarely, paragangliomas are located in other unusual sites, such as the gallbladder, mesentery, kidney, prostate, ovary and the esophagus [4,[7][8][9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Paragangliomas arise from neuroendocrine cells of the autonomic nervous system and commonly occur in the paraaortic area down to the aortic bifurcation; they can be uni-or multicentric [1]. Zuckerkandl first reported the distribution of these paraganglia [2].…”

Section: Introductionmentioning

confidence: 99%

Malignant abdominal paraganglioma with lymph node metastasis: report of a case

2009

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Zusammenfassung. Grundlagen: Paragangliome sind seltene Tumore und treten meistens entlang der abdominellen Aorta bis zur Aortenbifurkation auf. Die Diagnose wird oft zufällig bei der radiologischen Abklärung wegen Bauchschmerzes gestellt. Gut-und bösartige Tumore haben ein identisches klinisches, radiologisches und histologisches Erscheinen, nur das Auftreten von lokaler Invasion oder Fernmetastasen bestätigt die Malignität.Methodik: Wir berichten über einen 49-jährigen Patienten mit einem 6,5 cm in der größten Ausdehnung über der Bauchaorta liegenden Tumor, welcher mittels CT diagnostiziert wurde. Eine Resektion des Tumors mit aortocavaler Lymphadenektomie wurde durchgeführt.Ergebnisse: Die histopathologische Aufarbeitung des Operationspräparates ergab ein malignes Paragangliom mit Lymphknotenmetastasen. Der operative und postoperative Verlauf war komplikationslos.Schlussfolgerungen: Maligne abdominelle Paragangliome sind seltene Tumore und aufgrund des mit der gutartigen Form identischen klinischen, radiologischen und histologischen Auftretens bestätigt nur die Präsenz von lokaler Invasion oder von Fernmetastasen die Malignität. Die Therapie der Wahl ist die komplette chirurgische Resektion. Nur ein multidisziplinäres Vorgehen erlaubt eine optimale Behandlung dieser ausgewählten Patienten.Schlüsselwörter: Bösartig, abdominelles Paragangliom, Lymphknoten, Metastasen.Summary. Background: Paragangliomas are rare tumors that generally occur in the abdominal paraaortic area down to the aortic bifurcation. Diagnosis is often made incidentally during radiologic work-up for abdominal pain. As benign and malignant lesions have identical clinical, radiologic and histologic features, the malignant potential is determined by local invasion and distant metastases.Methods: We report a 49-year-old male who underwent lymphadenectomy for a retroperitoneal tumor with a largest dimension of 6.5 cm above the abdominal aorta, which was diagnosed by CT.Results: Histopathologic resection of the specimen showed malignant paraganglioma with lymph node metastasis. The operative and postoperative course was uneventful.Conclusions: Malignant abdominal paragangliomas are rare tumors whose clinical, radiologic and histologic presentations are identical to the benign form; only the presence of local invasion or distant metastases confirms malignancy. The treatment of choice is complete surgical resection. Only a multidisciplinary approach will allow optimal treatment for this selected group of patients.

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“…2 Therefore, surgical resection for PG is recommended as the mainstay of treatment after conservative medical management. 3 Because of its low morbidity, anatomic variation, and unstable hemodynamics during operative manipulation, both open and laparoscopic management are a great challenge even for the experienced urologist. Laparoscopic resection of retroperitoneal PG was first described by Janetschek and associates 4 in 1998.…”

Section: Introductionmentioning

confidence: 99%