Paragangliomas?A decade of clinical experience

Somasundar, Ponnandai; Krouse, Robert S.; Hostetter, R.; Vaughan, Richard; Covey, Thomas H.

doi:10.1002/1096-9098(200008)74:4<286::aid-jso9>3.0.co;2-c

Cited by 83 publications

(33 citation statements)

References 15 publications

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“…The clinical behavior of paragangliomas is determined by cellular characteristics, secreting capabilities, and tumor location. The symptoms and signs depend on the site of origin and the stage at which it presents [2]. Paragangliomas are rare with multicentricity being more common in patients with familial history.…”

Section: Discussionmentioning

confidence: 99%

Multiple Retroperitoneal Paragangliomas

Rai¹,

Subas

Kini

et al. 2012

Indian J Surg

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Paragangliomas are rare with multicentricity being more common in patients with familial history. Early recognition of the characteristic symptoms of headache, palpitations, and diaphoresis in a patient with hypertension and prompt appropriate intervention can minimize the morbidity associated with such tumors and prevent a potentially fatal outcome. Paragangliomas represent neoplasms of neural crest origin that arise from paraganglia. Paragangliomas are tumours arising in extra-adrenal paraganglia either in the paravertebral space. We report a rare case of two discrete paragangliomas in the retroperitoneum of a young girl presenting with throbbing headache. Contrast Enhanced CT Abdomen showed the lesions as a large irregular heterogeneous and intensely enhancing mass lesions. Elevated levels of vanillylmandelic acid were found in the Urine. The lesions were removed by surgery and the histopathologic findings of both the lesions confirmed the diagnosis of multiple paragangliomas. Early identification and early surgery will minimize the potential risks and complications in this condition.

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Section: Discussionmentioning

confidence: 99%

Multiple Retroperitoneal Paragangliomas

Rai¹,

Subas

Kini

et al. 2012

Indian J Surg

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“…EP is not sensitive to radiotherapy or chemotherapy, so surgical remove is believed to be the best choice for treatment of pheochromocytoma (4). Laparoscopic approach is widely accepted because of its minimal invasive advantage.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic resection of ectopic pheochromocytoma

Cai

Zhang

2017

IRDR

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“…13) The malignant form is defined by the presence of metastasis or local invasion rather than by the histological appearance, and accounts for 10-20% of all pheochromocytomas. 12,13) Malignant pheochromocytomas grow slowly and metastasize to bone, the liver, lymph nodes, and the lungs. 13) Vertebral metastases are relatively rare with only a few cases reported.…”

Section: Introductionmentioning

confidence: 99%

Multiple Vertebral Metastases from Malignant Cardiac Pheochromocytoma-Case Report-

Yamaguchi

Hida

Nakamura

et al. 2003

Neurol. Med. Chir.(Tokyo)

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A 27-year-old male presented with a very rare metastasis to the vertebral body from a cardiac pheochromocytoma manifesting as a pathological fracture of the C-4 vertebral body that occurred while playing golf. The patient was initially treated with hard collar fixation. Gallium scintigraphy demonstrated multiple hot spots in the mediastinum, the frontal bone, the vertebral column, and the rib. Magnetic resonance imaging of the chest delineated a cardiac tumor. The patient underwent biopsies of the cardiac and the frontal bone lesions. The diagnosis was malignant cardiac pheochromocytoma with multiple bone metastases. Initial irradiation of the cardiac and the vertebral lesions was followed by surgical intervention to the cervical spine to prevent aggravation of the kyphotic deformity and spinal cord compression. Preoperative embolization of the feeding arteries was followed by C-4 corpectomy, iliac bone grafting, and anterior titanium plating fixation. The patient was discharged and returned to work. However, 20 months later, he died of a metastatic brain lesion with systemic tumor progression.

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Paragangliomas?A decade of clinical experience

Cited by 83 publications

References 15 publications

Multiple Retroperitoneal Paragangliomas

Multiple Retroperitoneal Paragangliomas

Laparoscopic resection of ectopic pheochromocytoma

Multiple Vertebral Metastases from Malignant Cardiac Pheochromocytoma-Case Report-

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