Paraganglioma Presenting as Postpartum Fever of Unknown Origin

Narechania, Shraddha; Bath, Amrita; Ghassemi, Laleh; Lokhande, Chetan; Haddad, Abdo; Yousuf, Ali Mir; Marquard, Jessica; Gopalakrishna, K. V.

doi:10.1155/2015/864719

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Intolerance to prazosin 9 [12] 14 weeks Phenoxybenzamine Propranolol 10 [13] Recurrence during pregnancy Benzylamine Propranolol The therapeutic effects of compound hypotensive tablet, prazosin and magnesium sulfate were not ideal. Tumor removal during cesarean section 12 [14] 3 weeks Phenoxybenzamine 13 [15] 1 day Labetalol Hydralazine and magnesium sulfate 14 [16] The very induction day Labetalol Hydralazine 15 [17] 2 weeks Phenoxybenzamine Tumor removal during cesarean section 16 [18] After delivery Constant use Unspecified medication 17 [19] After delivery Nifedipine (adalat) Enalapril Hydrochlorothiazide 18 [20] After delivery Magnesium sulfate 19 [21] After delivery Unspecified medication. cesarean section at 28 weeks of gestation due to hypertension 20 [22] After delivery Phenoxybenzamine Metoprolol 21 [23] Diagnosed through pathological tests after delivery…”

Section: Note (Other Drugs) α-Blocker β-Blockermentioning

confidence: 99%

Ectopic pheochromocytomas in the third trimester: A case report and literature review

Zhao,

Chen,

Chen

et al. 2024

Medicine

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Introduction: To investigate the clinical features, pregnancy care, timing, and approaches of pregnancy termination as well as the perinatal management of pregnant women with ectopic pheochromocytomas (EPCC) (paragangliomas, PGL). Methods: We report the diagnosis and treatment of a pregnant women with EPCC which was confirmed in the third trimester in our hospital. Literature in relation to EPCC during pregnancy both in and outside China was searched for data analysis such as maternal clinical features and maternal and fetal prognosis. Results: A total of 20 papers including 21 cases (plus ours) were retrieved. The average age of pregnant patients was 28 years old (from 21 to 37). Two patients presented no hypertension. Nineteen had hypertension in various extent with the accompany of headache (11 cases, 57.9%), palpitations (8 cases, 42.1%), sweating (6 cases, 31.6%), nausea (6 cases), abdominal pain (2 cases), etc. The tumor was found in the chest in 3 patients, in the upper abdomen in 1 patient, in the middle abdomen in 10 patients, between the lower abdomen and pelvic cavity in 3 patients and in the pelvic cavity in 3 patients. Five patients had a surgical removal of the tumor before delivery, 3 during cesarean section and 10 after giving birth. Conclusion: EPCC (PGL) during pregnancy is a rare extra-adrenal tumor, whose manifestations are often confused with those of pregnancy-induced hypertension. It is extremely hard to diagnosis the disease before surgery. Patients still have an opportunity of undergoing spontaneous delivery if their tumors have been removed before labor. However, for patients whose pheochromocytomas is localized before labor, it is better to terminate their pregnancy via cesarean section in a proper time according to their obstetric conditions, while under the supervision of multidisciplinary specialists. The preparations of both α and β adrenergic receptor blocker treatment that is normally carried out before PGL removal surgery are unnecessary to be overemphasized before the cesarean section.

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Section: Note (Other Drugs) α-Blocker β-Blockermentioning

confidence: 99%

Ectopic pheochromocytomas in the third trimester: A case report and literature review

Zhao,

Chen,

Chen

et al. 2024

Medicine

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Síndromes endocrinológicos del posparto

Gricourt

Peigné

Luton

2019

EMC - Ginecología-Obstetricia

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Metastatic Paraganglioma of the Spine With SDHB Mutation: Case Report and Review of the Literature

et al. 2021

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Background: Paragangliomas (PGLs) are rare neuroendocrine tumors that can arise from any autonomic ganglion of the body. Most PGLs do not metastasize. Here, we present a rare case of metastatic PGL of the spine in a patient with a germline pathogenic succinate dehydrogenase subunit B (SDHB) mutation. Methods: In addition to a case report we provide a literature review of metastatic spinal PGL to highlight the importance of genetic testing and long-term surveillance of these patients. Results: A 45-year-old woman with history of spinal nerve root PGL, 17 years prior, presented with back pain of several months' duration. Imaging revealed multilevel lytic lesions throughout the cervical, thoracic, and lumbar spine as well as involvement of the right mandibular condyle and clavicle. Percutaneous biopsy of the L1 spinal lesion confirmed metastatic PGL and the patient underwent posterior tumor resection and instrumented fusion of T7-T11. Postoperatively the patient was found to have a pathogenic SDHB deletion. Conclusions: Patients with SDHx mutation, particularly SDHB, have increased risk of developing metastatic PGLs. Consequently, these individuals require long-term surveillance given the risk for developing new tumors or disease recurrence, even years to decades after primary tumor resection. Surgical management of spinal metastatic PGL involves correcting spinal instability, minimizing tumor burden, and alleviating epidural cord compression. In patients with metastatic PGL of the spine, genetic testing should be considered.

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Paraganglioma Presenting as Postpartum Fever of Unknown Origin

Cited by 4 publications

References 17 publications

Ectopic pheochromocytomas in the third trimester: A case report and literature review

Ectopic pheochromocytomas in the third trimester: A case report and literature review

Síndromes endocrinológicos del posparto

Metastatic Paraganglioma of the Spine With SDHB Mutation: Case Report and Review of the Literature

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