Paraganglioma of the tongue with SDHB gene mutation in a patient with Graves’ disease

Abstract

Key Clinical Message We report a case of an apparently sporadic paraganglioma of the tongue with a germ‐line mutation in a female patient with asymptomatic Graves’ disease. The tongue is an unusual primary location. Genetic testing is mandatory in all cases. Thyroid gland dysfunction and autoimmune phenomena could be associated with some paragangliomas.

Paraganglioma of the Tongue in a Chow Chow Dog: A Comparison With the Human Counterpart and Literature Review

“…In human patients, there are different cytological presentations of paragangliomas of the head (19,20), including similar morphological features such as observed in the dog. Cytological diagnosis of paragangliomas of the tongue has never been conducted in human patients (14)(15)(16)(17)(18). Cytological findings…”

“…Chow Chow dog Human cases (14)(15)(16)(17)(18) Anatomical location Right side of the lingual body extending to the base of the tongue Base of the tongue (14,16), lateral of the middle third of the tongue (15), lingual posterior aspect (17), back of the tongue squeezing the pharyngeal cavity (18).…”

“…Sialorrhea, oral bleeding during eating, halitosis, and dysphagia Paresthesia, oral bleeding during eating (14), biting on the lesion, swelling, and pain (15), chronic throat irritation (16), asymptomatic (17), impairment of pronunciation, and sleep snoring (18).…”

“…Mass connected to the epiglottis and almost obliterating the entire oropharynx (14), swelling of the tongue (15), small granulating mass (16), single lingual nodule (17,18).…”

“…Polygonal cells grouped in nests and surrounded by a net of thin fibrovascular septae (15)(16)(17)(18), "Zellballen" appearance (16,17), round nuclei within fine-grained chromatin (16)(17)(18), granular eosinophilic cytoplasm (16) PAS-negative stained (15), uniform cells without atypia, mitosis, or necrosis (16,17).…”