Paraganglioma of the filum terminale internum

Abstract

A case of paraganglioma of the filum terminale is presented where normal sympathetic ganglion cells were seen in conjunction with tumour cells in a well-encapsulated tumour, suggesting a possible origin from heterotopic sympathetic ganglion.

Paraganglioma of the Filum Terminale: An Extremely Uncommon Neuroendocrine Neoplasm Located in Spine

“…Its occurrence is extremely rare, about 150 cases of spinal paraganglioma is reported in literature, mostly in the form of an isolated case reports. [12345789101112131415161718192021] Authors report an interesting and unique case of paraganglioma developing in the filum terminale presented with progressive paraparesis.…”

“…[135] Spinal cord paragangliomas are usually tend to occur at the end of the spinal column below L1 vertebral level, but less commoner sites include cervical and thoracic regions; however, most of the published cases were located at cauda equina or filum terminale. [1256101215] Paraganglioma occurring in the cauda equina represents approximately 3%–4% of spinal lesions. [2101718192021]…”

“…Spinal paraganglioma is presumably derived from ganglion cells, normal paragangliomas associated with blood vessels or from residual peripheral neuroblasts, which can give rise to either chemoreceptor ganglion cells. [5]…”

“…[15] It may be associated with syringomyelia or intramedullary cyst. [312] Paraganglioma is pathologically considered as benign lesion with slow-growing mass possessing relatively low proliferative activity[1118] although malignant potentials are also occasionally reported by Blades et al .…”