Paraffin-Gel Tissue-Mimicking Material for Ultrasound-Guided Needle Biopsy Phantom

Vieira, Sílvio Leão; Pavan, Theo Z.; Jorge, Érika Cristina; Carneiro, Adriana Munhoz

doi:10.1016/j.ultrasmedbio.2013.06.008

Cited by 82 publications

(53 citation statements)

References 23 publications

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“…Polymers and elastomers tend to have dissimilar speed of sound to tissue (e.g., silicone at 1030 m∕s 24 or polydimethylsiloxane at 1300 m∕s 25 ) while liquid fat emulsions possess low-acoustic attenuation, present a limited tuning range for speed of sound, 26 and degrade over time. Paraffin-based materials have been produced for ultrasound biopsy phantoms 27 and three-dimensional printed optical phantoms, 28 but it is unclear whether simultaneous optical and acoustic tuning can be achieved. Hydrogels such as agarose and gelatin containing hairs, absorbing inclusions, or fluid channels are commonly used for photoacoustic phantoms, 17,[29][30][31][32][33][34] but hydrogel material properties and overall gel mechanical strength typically destabilize quickly over a matter of days, making them ill-suited for long-term quality control or calibration phantoms.…”

Section: Review Of Photoacoustic Phantom Materialsmentioning

confidence: 99%

Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties

et al. 2016

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Abstract. Established medical imaging technologies such as magnetic resonance imaging and computed tomography rely on well-validated tissue-simulating phantoms for standardized testing of device image quality. The availability of high-quality phantoms for optical-acoustic diagnostics such as photoacoustic tomography (PAT) will facilitate standardization and clinical translation of these emerging approaches. Materials used in prior PAT phantoms do not provide a suitable combination of long-term stability and realistic acoustic and optical properties. Therefore, we have investigated the use of custom polyvinyl chloride plastisol (PVCP) formulations for imaging phantoms and identified a dual-plasticizer approach that provides biologically relevant ranges of relevant properties. Speed of sound and acoustic attenuation were determined over a frequency range of 4 to 9 MHz and optical absorption and scattering over a wavelength range of 400 to 1100 nm. We present characterization of several PVCP formulations, including one designed to mimic breast tissue. This material is used to construct a phantom comprised of an array of cylindrical, hemoglobin-filled inclusions for evaluation of penetration depth. Measurements with a custom near-infrared PAT imager provide quantitative and qualitative comparisons of phantom and tissue images. Results indicate that our PVCP material is uniquely suitable for PAT system image quality evaluation and may provide a practical tool for device validation and intercomparison. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Review Of Photoacoustic Phantom Materialsmentioning

confidence: 99%

Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties

et al. 2016

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“…The phantoms used in this research were BB-1 model (breast biopsy phantom, ATS Laboratories) and models previously developed by Vieira et al [7]. All the phantoms were made of an acoustically tissue mimicking material and have a shape similar to the breast of an adult woman.…”

Section: Methodsmentioning

confidence: 99%

“…Breast biopsy phantoms designed for ultrasound images: (a) BB-1 model from ATS Laboratories and (b) models developed by Vieira et al [7]. …”

Section: Figurementioning

confidence: 99%

Application of Artificial Neural Network Models in Segmentation and Classification of Nodules in Breast Ultrasound Digital Images

Marcomini

Carneiro

Schiabel

2016

International Journal of Biomedical Imaging

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This research presents a methodology for the automatic detection and characterization of breast sonographic findings. We performed the tests in ultrasound images obtained from breast phantoms made of tissue mimicking material. When the results were considerable, we applied the same techniques to clinical examinations. The process was started employing preprocessing (Wiener filter, equalization, and median filter) to minimize noise. Then, five segmentation techniques were investigated to determine the most concise representation of the lesion contour, enabling us to consider the neural network SOM as the most relevant. After the delimitation of the object, the most expressive features were defined to the morphological description of the finding, generating the input data to the neural Multilayer Perceptron (MLP) classifier. The accuracy achieved during training with simulated images was 94.2%, producing an AUC of 0.92. To evaluating the data generalization, the classification was performed with a group of unknown images to the system, both to simulators and to clinical trials, resulting in an accuracy of 90% and 81%, respectively. The proposed classifier proved to be an important tool for the diagnosis in breast ultrasound.

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“…Phantoms developed for 3D US imaging were constructed using medium density paraffin gel wax [29]. These phantoms allow 90° transducer positioning without the need to submerge the imaging probes deep into water.…”

Section: B Phantom Constructionmentioning

confidence: 99%

3-D In Vitro Acoustic Super-Resolution and Super-Resolved Velocity Mapping Using Microbubbles

Christensen-Jeffries

Brown

Aljabar

et al. 2017

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Abstract-Standard clinical ultrasound (US) imagingfrequencies are unable to resolve microvascular structures due to the fundamental diffraction limit of US waves. Recent demonstrations of 2D super-resolution both in vitro and in vivo have demonstrated that fine vascular structures can be visualized using acoustic single bubble localization. Visualization of more complex and disordered 3D vasculature, such as that of a tumor, requires an acquisition strategy which can additionally localize bubbles in the elevational plane with high precision in order to generate super-resolution in all three dimensions. Furthermore, a particular challenge lies in the need to provide this level of visualization with minimal acquisition time. In this work, we develop a fast, coherent US imaging tool for microbubble localization in 3D using a pair of US transducers positioned at 90°. This allowed detection of point scatterer signals in 3 dimensions with average precisions equal to 1.9 µm in axial and elevational planes, and 11 µm in the lateral plane, compared to the diffraction limited point spread function full widths at half maximum of 488 µm, 1188 µm and 953 µm of the original imaging system with a single transducer. Visualization and velocity mapping of 3D in vitro structures was demonstrated far beyond the diffraction limit. The capability to measure the complete flow pattern of blood vessels associated with disease at depth would ultimately enable analysis of in vivo microvascular morphology, blood flow dynamics and occlusions resulting from disease states.

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Paraffin-Gel Tissue-Mimicking Material for Ultrasound-Guided Needle Biopsy Phantom

Cited by 82 publications

References 23 publications

Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties

Biologically relevant photoacoustic imaging phantoms with tunable optical and acoustic properties

Application of Artificial Neural Network Models in Segmentation and Classification of Nodules in Breast Ultrasound Digital Images

3-D In Vitro Acoustic Super-Resolution and Super-Resolved Velocity Mapping Using Microbubbles

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