In this paper, we propose a viable approach to realise two texture-zeros in the scotogenic model with flavor dependent U (1) B−2Lα−L β gauge symmetry. These models are extended by two righthanded singlets N Ri and two inert scalar doublets η i , which are odd under the dark Z 2 symmetry.Among all the six constructed textures, texture A 1 and A 2 are the only two allowed by current experimental limits. Then choosing texture A 1 derived from U (1) B−2Le−Lτ , we perform a detail analysis on the corresponding phenomenology such as predictions of neutrino mixing parameters, lepton flavor violation, dark matter and collider signatures. One distinct nature of such model is that the structure of Yukawa couplingLηN R is fixed by neutrino oscillation data, and can be further tested by measuring the branching ratios of charged scalars η ± 1,2 .