Paradoxical worsening of tics with haloperidol

Nath, Kamal; Bhattacharya, Aniruddha; Hazarika, Susmita; Roy, Debjit; Praharaj, Samir Kumar

doi:10.1177/2045125315591915

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Recent reviews and meta-analyses including studies using haloperidol for the treatment of tics support above-mentioned adverse effects: EPS, tremor, tardive dyskinesia, drowsiness, fatigue, headache, nausea/vomiting, dry mouth, emotional hypersensivity, insomnia, irritability, and nightmares. ,, Furthermore, paradoxical worsening of tics with haloperidol has been reported in a single case in 1987 and again in a single case in 2015 …”

Section: Systematic Review Of Dopamine Receptor Antagonists For the T...mentioning

confidence: 95%

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Update on the Pharmacological Treatment of Tics with Dopamine-Modulating Agents

Mogwitz

Buse

Wolff

et al. 2018

ACS Chem. Neurosci.

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More than 40 years of research and clinical practice have proven the effectiveness of dopamine receptor antagonists in the pharmacological treatment of tics. A blockade of the striatal dopamine-D2 receptors is mainly responsible for their tic-reducing effect. A broad spectrum of dopamine-modulating agents, such as typical and atypical antipsychotics, but also dopamine receptor agonists are used with an immanent discord between experts about which of them should be considered as first choice. The present Review outlines the state of the art on pharmacological treatment of tics with dopamine-modulating agents by giving an systematic overview of studies on their effectiveness and a critical discussion of their specific adverse effects. It is considered as an update of a previous review of our research group published in 2013. The Review closes with a description of the current resulting treatment recommendations including the results of a first published revised survey on European expert's prescription preferences. Based on the enormously growing evidence on its effectiveness and safety, aripiprazole currently seems to be the most promising agent in the pharmacological treatment of tics. Furthermore, benzamides (especially tiapride), which are commonly used in Europe, have proven their excellent effectiveness-tolerability profile over decades in clinical practice and are therefore also highly recommended for the treatment of tics. Nevertheless, pharmacological treatment of tics remains an indiviual choice depending on each patient's own specific needs.

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Section: Systematic Review Of Dopamine Receptor Antagonists For the T...mentioning

confidence: 95%

“…33,44,41 Furthermore, paradoxical worsening of tics with haloperidol has been reported in a single case in 1987 106 and again in a single case in 2015. 107 2.1.2. Pimozide.…”

Section: Systematic Review Of Dopamine Receptormentioning

confidence: 99%