Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Frussa‐Filho, Roberto; Gonçalves, Michele Themis Moraes; Andersen, Mônica Levy; Araujo, N.P.; Chinen, Cibele Cristina; Tufik, Sérgio

doi:10.1016/j.brainres.2003.11.050

Cited by 70 publications

(17 citation statements)

References 30 publications

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“…Thus, a more probable explanation would be a conditioned response to the exposure to an environment to which the animals had been previously exposed in the presence of ETOH stimulating effect. In this respect, a conditioned response in the absence of ETOH or other abuse drugs after previous pairing to an environment has been demonstrated (Cunningham and Noble 1992;Vanderschuren et al 1999;Frussa-Filho et al 2004). …”

Section: Discussionmentioning

confidence: 94%

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

et al. 2007

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Section: Discussionmentioning

confidence: 94%

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

et al. 2007

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“…Hand-operated counters were used to score locomotion frequency (number of floor units entered) during the 5-min sessions. This period of time has been demonstrated to be effective in detecting AMP-induced behavioral sensitization in mice (Bellot et al, 1997;Costa et al, 2001;Frussa-Filho et al, 2004). All the observations were conducted blind.…”

Section: General Methodsmentioning

confidence: 99%

“…Concerning the environmental context, it has been suggested that environmental cues might be conditioned stimuli for drug-like conditioned responses, potentiating the development of behavioral sensitization (Hayashi et al, 1980;Pierce and Kalivas, 1997;Costa et al, 2001;Frussa-Filho et al, 2004). Although sensitization of the locomotor-activating effect of AMP and other drugs of abuse has been also observed when drug injections are not paired with the observation environment (Bellot et al, 1996(Bellot et al, , 1997Costa et al, 2001), this environmental modulation of sensitization is especially interesting because it is well known that environmental cues trigger craving and drug-seeking behavior in humans (Childress et al, 1986;Niaura et al, 1988;Carter and Tiffany, 1999).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Rapid-Onset Type of Behavioral Sensitization to Amphetamine in Mice: Role of Drug–Environment Conditioning

Chinen

Faria

Frussa‐Filho

2005

Neuropsychopharmacol

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A rapid-onset type of behavioral sensitization (ROBS) has been demonstrated in rats treated with a single 'priming' injection of amphetamine (AMP). In that species, however, this phenomenon was restricted to AMP-induced stereotyped behavior (SB), not occurring for the locomotor-stimulant effect (LSE) of AMP and not reflecting environment-specific sensitization. In the present study, the ROBS was characterized in the mouse. Mice received a single 'priming' intraperitoneal injection of 5.0 mg/kg AMP which was paired or not with environment. At different intervals (3, 4 or 5 h) subgroups were tested for AMP (1.5 or 5.0 mg/kg)-induced SB or AMP (1.5 mg/kg)-induced open-field LSE. Results showed that: (1) in the absence of drug-environment association, a priming injection of AMP increased the SB induced by a 1.5 mg/kg AMP challenge injection given 3 h (but not 4 or 5 h) later; (2) when the dose of AMP challenge injection was increased to 5.0 mg/kg, an enhancement of SB was verified at all the intervals tested (3, 4, and 5 h); (3) when animals were tested in an open field, the priming injection of AMP produced an increase in the LSE of a 1.5 mg/kg AMP challenge injection, given 4 h later; (4) drug-environment association increased both SB and locomotion after a saline challenge injection and potentiated the rapid-onset sensitization of both behaviors in AMP-challenged mice. Collectively, these results demonstrate that the ROBS phenomenon also occurs in mice, is extended to AMP-induced LSE, and is markedly potentiated by (but does not depend on) environmental conditioning. Neuropsychopharmacology (2006) 31, 151-159.

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“…Regarding the effect of PSD on locomotor activity (Tufik and Silveira-Filho 1983, Frussa-Filho et al 2004, Andersen et al 2005b, Perry et al 2007), some studies have focused on locomotor activity and sleep patterns. Consequently, speculations about the effect of the exercise on sleep due to sleep deprivation have been raised (Martins et al 2001).…”

Section: Locomotor and Anxiety-like Behaviormentioning

confidence: 99%

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

Tufik

Andersen

Bittencourt

et al. 2009

An. Acad. Bras. Ciênc.

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144

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Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.

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Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Cited by 70 publications

References 30 publications

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

Dissociation of the effects of ethanol on memory, anxiety, and motor behavior in mice tested in the plus-maze discriminative avoidance task

Characterization of the Rapid-Onset Type of Behavioral Sensitization to Amphetamine in Mice: Role of Drug–Environment Conditioning

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research

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