Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology

Tse, Brian Wan-Chi; Scott, K. John; Russell, Pamela J.

doi:10.1155/2012/128965

Cited by 60 publications

(58 citation statements)

References 65 publications

(86 reference statements)

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“…However, the higher amounts initiate tumor cell death and stimulate the antitumor response (Tse et al 2012). It is believed that chronic inflammation is one of the main risk factors for the development of carcinogenesis process, in which TNF-α plays an extremely important role.…”

Section: Tnf-α In Cancer and Cancerogenesismentioning

confidence: 99%

The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker

Grabarek

Bednarczyk

Mazurek

2017

FBOe

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The inflammatory process is directly associated with secretion of cytokines, e.g. tumor necrosis factor alpha (TNF-α). This molecule is one of the 22 proteins which belong to TNF family and is secreted mainly by: macrophages, monocytes, T lymphocyte and mast cells. The biological effects of TNF-α is possible through binding this cytokine to specific receptors – TNFR1 and TNFR2. The large number of reports provides that this cytokine plays extremely important role in cancers and cardiovascular disease – two groups of inflammatory diseases. Unfortunately, these diseases are the main cause of death in spite of advances in medicine and increasing public awareness of prevention. It is believed that better understanding both molecular potential of this cytokine and the impact in cancerogenesis and others inflammatory diseases may cause using TNF-α as a molecular marker in these diseases and will make it possible to observe the effects of anti-inflammatory therapy. It will be able to cause a drop in the incidence of these diseases and better monitoring of them.

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Section: Tnf-α In Cancer and Cancerogenesismentioning

confidence: 99%

The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker

Grabarek

Bednarczyk

Mazurek

2017

FBOe

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“…Interactions between tumor-derived IL-6 and TAMs-derived TNF-α enhanced incidence of prostate cancer metastases both to the bones and regional lymph nodes [314]. Moreover, prostate tumors have been characterized by increased TNF-α, TNFR1, and TNFR2 levels, which correlated with poor prognosis [315].…”

Section: Inflammation and Cancer Escapementioning

confidence: 99%

Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors

Wilczyński

Nowak

2013

Interaction of Immune and Cancer Cells

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Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been replaced by the current concept of cancer immunoediting consisting of three phases: elimination, equilibrium, and escape. Solid tumors composed of both cancer and host stromal cells are an example of how the three phases of cancer immunoediting functionally evolve, and how a tumor shaped by the host immune system gets a finally resistant phenotype. Elimination, equilibrium, and escape are described in this chapter in detail, including the role of immune surveillance, cancer dormancy, disruption of the antigen-presenting machinery, tumor-infiltrating immune cells, and resistance to apoptosis, as well as the function of tumor stroma, microvesicles, exosomes and inflammation.

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“…Among them, recombinant human tumour necrosis factor alpha (rhTNFa) is one of the most investigated biomarkers because several studies demonstrated its potential application in diagnostic and therapeutic applications [8][9][10]. Indeed, rhTNFa is an inflammatory cytokine mainly secreted in response to a diverse range of stresses [8,9], overexpressed in the microenvironment of many tumours and responsible, in most cases, for their progression [11,12].…”

Section: Introductionmentioning

confidence: 99%

Integration of binding peptide selection and multifunctional particles as tool-box for capture of soluble proteins in serum

Cusano

Causa

Moglie

et al. 2014

J. R. Soc. Interface.

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In this paper, we report on a general approach for the detection of a specific tumoural biomarker directly in serum. Such detection is made possible using a protein-binding peptide selected through an improved phage display technique and then conjugated to engineered microparticles (MPs). Protein biomarkers represent an unlimited source of information for non-invasive diagnostic and prognostic tests; MP-based assays are becoming largely used in manipulation of soluble biomarkers, but their direct use in serum is hampered by the complex biomolecular environment. Our technique overcomes the current limitations as it produces a selective MP-engineered with an antifouling layer-that 'captures' the relevant protein staying impervious to the background. Our system succeeds in fishing-out the human tumour necrosis factor alpha directly in serum with a high selectivity degree. Our method could have great impact in soluble protein manipulation and detection for a wide variety of diagnostic applications.

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Paradoxical Roles of Tumour Necrosis Factor-Alpha in Prostate Cancer Biology

Cited by 60 publications

References 65 publications

The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker

The characterization of tumor necrosis factor alpha (TNF-α), its role in cancerogenesis and cardiovascular system diseases and possibilities of using this cytokine as a molecular marker

Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors

Integration of binding peptide selection and multifunctional particles as tool-box for capture of soluble proteins in serum

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