Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors

Baretella, Oliver; Chung, Sookja K.; Xu, Aimin; Vanhoutte, Paul M.

doi:10.1038/aps.2017.155

Cited by 3 publications

(1 citation statement)

References 10 publications

(24 reference statements)

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“…Although obesity is known to contribute to excess aldosterone in patients with resistant hypertension, 20 we found that aldosterone levels were lower in individuals with a higher BMI. A paradoxical lack of increase in endothelin-1 levels in obese mice has been previously observed 21 ; we now show that a higher BMI was associated with lower CT-proET-1 levels in community-dwelling adults.…”

Section: Table 2 Predictive Value Of Selected Biomarkers Across Body Mass Index Categoriessupporting

confidence: 78%

Relationship between body mass index, cardiovascular biomarkers and incident heart failure

Suthahar

Meems

Groothof

et al. 2021

European J of Heart Fail

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Section: Table 2 Predictive Value Of Selected Biomarkers Across Body Mass Index Categoriessupporting

confidence: 78%

Relationship between body mass index, cardiovascular biomarkers and incident heart failure

Suthahar

Meems

Groothof

et al. 2021

European J of Heart Fail

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show abstract

Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity

et al. 2022

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Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

et al. 2021

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Endothelin-1 (ET-1) is elevated in patients with obesity; however, its contribution to the pathophysiology related to obesity is not fully understood. We hypothesized that high ET-1 levels cause dyslipidemia, inflammation, and insulin resistance within the adipose tissue of obese mice. To test this hypothesis, male C57BL/6J mice were fed either normal diet (NMD) or high fat diet (HFD) for 8 weeks followed by 2 weeks of treatment with either vehicle, atrasentan (ETA receptor antagonist, 10mg/kg/day), or bosentan (ETA/ETB receptor antagonist, 100mg/kg/day). Atrasentan and bosentan lowered circulating non-esterified free fatty acids and triglycerides seen in HFD mice, while atrasentan-treated mice had significantly lower liver triglycerides compared to non-treated HFD mice. ET-1 receptor blockade significantly improved insulin tolerance compared to insulin resistant HFD mice and lowered expression of genes in epididymal white adipose tissue (eWAT) associated with insulin resistance and inflammation. Flow cytometric analyses of eWAT indicated that HFD mice had significantly higher percentages of both CD4+ and CD8+ T cells compared to NMD mice, which was attenuated by treatment with atrasentan or bosentan. Atrasentan treatment also abolished the decrease in eosinophils seen in HFD mice. Taken together, these data indicate that ETA and ETA/ETB receptor blockade improves peripheral glucose homeostasis, dyslipidemia, and liver triglycerides, and also attenuates the proinflammatory immune profile in eWAT of mice fed a HFD. These data suggest a potential use for ETA and ETA/ETB receptor blockers in the treatment of obesity-associated dyslipidemia and insulin resistance.

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Paradoxical lack of increase in endothelin-1 levels in obese mice – possible role of endothelin-B receptors

Cited by 3 publications

References 10 publications

Relationship between body mass index, cardiovascular biomarkers and incident heart failure

Relationship between body mass index, cardiovascular biomarkers and incident heart failure

Mid-regional proadrenomedullin, C-terminal proendothelin-1 values, and disease course are not different in critically ill SARS-CoV-2 pneumonia patients with obesity

Endothelin receptor antagonism improves glucose handling, dyslipidemia, and adipose tissue inflammation in obese mice

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