Paradoxical improvement of cognitive control in older adults under dual-task walking conditions is associated with more flexible reallocation of neural resources: A Mobile Brain-Body Imaging (MoBI) study

Patelaki, Eleni; Foxe, John J.; Mantel, Emma P.; Kassis, George; Freedman, Edward G.

doi:10.1016/j.neuroimage.2023.120098

Cited by 12 publications

(24 citation statements)

References 149 publications

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“…The improved network flexibility was significantly correlated with the enhancement of gait speed, stride length, and arm range of motion (figure 6(a)). Previous studies showed that neural flexibility was correlated with motor performances in both healthy and older individuals, and higher neural flexibility was associated with better gait performances [71][72][73]. Our study was consistent with the above results, demonstrating the significant correlation between enhanced network flexibility and improved brain functions.…”

Section: Discussionsupporting

confidence: 92%

A dynamic brain network decomposition method discovers effective brain hemodynamic sub-networks for Parkinson’s disease

Lu,

Zhang,

Shu

et al. 2024

J. Neural Eng.

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Objective.Dopaminergic treatment is eﬀective for Parkinson’s disease (PD). Nevertheless, the conventional treatment assessment mainly focuses on human-administered behavior examination while the underlying functional improvements have not been well explored. This paper aims to investigate brain functional variations of PD patients after dopaminergic therapy.Approach. This paper proposed a dynamic brain network decomposition method and discovered brain hemodynamic sub-networks that well characterized the eﬃcacy of dopaminergic treatment in PD. Firstly, a clinical walking procedure with functional near-infrared spectroscopy (fNIRS) was developed, and brain activations during the procedure from ﬁfty PD patients under the OFF and ON states (without and with dopaminergic medication) were captured. Then, dynamic brain networks were constructed with sliding-window analysis of phase lag index and integrated time-varying functional networks across all patients. Afterwards, an aggregated network decomposition algorithm was formulated based on aggregated eﬀectiveness optimization of functional networks in spanning network topology and cross-validation network variations, and utilized to unveil eﬀective brain hemodynamic sub-networks for PD patients. Further, dynamic sub-network features were constructed to characterize the brain ﬂexibility and dynamics according to the temporal switching and activation variations of discovered sub-networks, and their correlations with diﬀerential treatment-induced gait alterations were analyzed.Results.The results demonstrated that PD patients exhibited signiﬁcantly enhanced ﬂexibility after dopaminergic therapy within a sub-network related to the improvement of motor functions. Other sub-networks were signiﬁcantly correlated with trunk-related axial symptoms and exhibited no signiﬁcant treatment-induced dynamic interactions. Signiﬁcance. The proposed method promises a quantiﬁed and objective approach for dopaminergic treatment evaluation. Moreover, the ﬁndings suggest that the gait of PD patients comprises distinct motor domains, and the corresponding neural controls are selectively responsive to dopaminergic treatment.

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Section: Discussionsupporting

confidence: 92%

A dynamic brain network decomposition method discovers effective brain hemodynamic sub-networks for Parkinson’s disease

Lu,

Zhang,

Shu

et al. 2024

J. Neural Eng.

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“…Furthermore, we observed a higher amplitude of the P3 component during the dual task than in the Oddball Task. This finding seems to contradict previous studies suggesting that CMI would lead to the opposite effect: a disruption of neural dynamics, such as a reduction in P3 amplitude during the dual task (walking) than in the standard Oddball task (standing) [25,54,55]. However, this discrepancy may be attributed to the relative simplicity of both tasks and the overall health profile of the young participants.…”

Section: Discussioncontrasting

confidence: 79%

“…However, this discrepancy may be attributed to the relative simplicity of both tasks and the overall health profile of the young participants. As indicated in recent studies, healthy young adults can adapt their gait and task-related behavior during walking to optimize their response to cognitive stimuli [49,55]. This interpretation finds additional support in the results of RT and NASA questionnaire scores, suggesting that the dual task does not impose a higher cognitive load compared to the Oddball task.…”

Section: Discussionsupporting

confidence: 65%

Understanding Pedestrian Cognition Workload in Traffic Environments Using Virtual Reality and Electroencephalography

Luque,

Armada,

Piovano

et al. 2024

Electronics

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Understanding pedestrians’ cognitive processes in traffic environments is crucial for developing strategies to enhance safety and reduce accidents. This study assesses the efficacy of virtual reality (VR) in evaluating pedestrian behavior in simulated road-crossing scenarios. It investigates VR’s capability to realistically mimic the cognitive load experienced in real-world settings. It examines the technical integration of VR with psychophysiological recording to capture cognitive demand indicators accurately. Utilizing a dedicated VR application and electroencephalogram (EEG) measurements, this research aims to elicit significant Event-Related Potentials (ERP), like P3 and Contingent Negative Variation (CNV), associated with decision-making processes. The initial results demonstrate VR’s effectiveness in creating realistic environments for investigating cognitive mechanisms and the balance between induced immersion and experienced discomfort. Additionally, the tasks involving time-to-arrival estimations and oddball scenarios elicited the anticipated components related to attentional and decision-making processes. Despite increased discomfort with extended VR exposure, our results show that it did not negatively impact the cognitive workload. These outcomes highlight VR’s efficacy in replicating the cognitive demands of real-world settings and provide evidence to understand the neurophysiological and behavioral dynamics of vulnerable road users (VRUs) in traffic scenarios. Furthermore, these findings support VR’s role in behavioral and neurophysiological research to design specific safety interventions for VRUs.

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“…This implies that the activities assigned to participants in the dual-task training group (task + cognitive task) are significantly more challenging than those assigned to participants in the single-task training group (task only). The task integration hypothesis posits that engaging in activities that require simultaneous cognitive and physical exertion forces the brain to optimize its resource allocation [28]. This integration leads to improvements in both cognitive and motor functions as the brain learns to handle multiple demands more efficiently.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of a Dual-Task Intervention Involving Exercise and Vocalized Cognitive Tasks

Abo,

Hamaguchi

2024

JCM

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Background/Objectives: Population aging is rapidly increasing, and the importance of preventive medicine has been stressed. Health checkups, diet, and exercise are of paramount importance. This study aimed to evaluate the effectiveness of a personalized dual-task intervention that combined exercise with cognitive tasks in improving physical and cognitive functions among independently living older individuals. Methods: Participants aged >65 years who were mostly independent in their activities of daily living were divided into two groups. The group receiving the 20 min robot-assisted session was compared with the group receiving traditional functional restoration training. This randomized trial assessed the impact of this intervention on the 30 s chair stand test score and Montreal Cognitive Assessment—Japanese version score of the participants. Results: Both scores significantly improved in the intervention group, indicating enhanced lower-limb function and cognitive capabilities. Conclusions: These findings suggest that integrating cognitive tasks with physical exercise can stand as an effective strategy to improve overall well-being in older people, offering valuable insights for designing comprehensive preventive health programs tailored to this demographic.

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Paradoxical improvement of cognitive control in older adults under dual-task walking conditions is associated with more flexible reallocation of neural resources: A Mobile Brain-Body Imaging (MoBI) study

Cited by 12 publications

References 149 publications

A dynamic brain network decomposition method discovers effective brain hemodynamic sub-networks for Parkinson’s disease

A dynamic brain network decomposition method discovers effective brain hemodynamic sub-networks for Parkinson’s disease

Understanding Pedestrian Cognition Workload in Traffic Environments Using Virtual Reality and Electroencephalography

Effectiveness of a Dual-Task Intervention Involving Exercise and Vocalized Cognitive Tasks

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