Paradoxical effects of short-term antidepressant treatment in fMRI emotional processing models in volunteers with high neuroticism

Simplicio, Martina Di; Norbury, Ray; Reinecke, Andrea; Harmer, Catherine J.

doi:10.1017/s0033291713000731

Cited by 63 publications

(60 citation statements)

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“…Another study found that 7 days of citalopram increased amygdala response to fearful faces, as well as to happy and neutral faces, in high-Ns [38]. This increased amygdala response to fearful faces is in contrast to both unselected healthy populations [23] and depressed patients [37].…”

Section: (C) Studies With High Neurotic Volunteersmentioning

confidence: 96%

“…The effect of acute antidepressant treatment on neural activity in depressed participants remains to be explored. In particular, it would be interesting to see whether the neural correlates of the acute anxiogenic effects of SSRIs might be seen more clearly in this population than in healthy volunteers, as has been suggested [38].…”

Section: (B) Depressed Patient Studiesmentioning

confidence: 97%

See 1 more Smart Citation

A neurocognitive model for understanding treatment action in depression

Warren

Pringle

Harmer

2015

Phil. Trans. R. Soc. B

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One contribution of 15 to a theme issue 'Controlling brain activity to alter perception, behaviour and society'. The way in which emotion is represented and processed in the human brain is an expanding area of research and has key implications for how we understand and potentially treat affective disorders such as depression. Characterizing the effects of pharmacological manipulations of key neurotransmitter systems can also help reveal the neurochemical underpinnings of emotional processing and how common antidepressant drugs may work in the treatment of depression and anxiety. This approach has revealed that depression is associated with both neural and behavioural biases towards negative over positive stimuli. Evidence from pharmacological challenge studies suggests that antidepressant treatment acts to normalize these biases early on in treatment, resulting in patients experiencing the world in a more positive way, improving their mood over time. This model is supported by evidence from both pharmacological and non-pharmacological interventions. The unique perspective on antidepressant treatment offered by this approach provides some insights into individual response to treatment, as well as novel approaches to drug development.

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Section: (C) Studies With High Neurotic Volunteersmentioning

confidence: 96%

Section: (B) Depressed Patient Studiesmentioning

confidence: 97%

A neurocognitive model for understanding treatment action in depression

Warren

Pringle

Harmer

2015

Phil. Trans. R. Soc. B

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“…These tasks required participants to indicate the type of emotion expressed in faces briefly presented on a computer screen (Attenburrow et al, 2003;Harmer, Rogers, et al, 2003;Kerestes et al, 2009). Adaptations were used by others (Beacher et al, 2011;Bilderbeck et al, 2013;Di Simplicio et al, 2013;Passamonti et al, 2012;Simonsen et al, 2014). For example, Beacher et al (2011) asked participants to rate faces in terms of attractiveness.…”

Section: Computer Tasks Used To Date Have Limited Ecological Validitymentioning

confidence: 99%

Studying the neurobiology of human social interaction: Making the case for ecological validity

Hogenelst

Schoevers

Rot

2015

Social Neuroscience

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With this commentary we make the case for an increased focus on the ecological validity of the measures used to assess aspects of human social functioning. Impairments in social functioning are seen in many types of psychopathology, negatively affecting the lives of psychiatric patients and those around them. Yet the neurobiology underlying abnormal social interaction remains unclear. As an example of human social neuroscience research with relevance to biological psychiatry and clinical psychopharmacology, this commentary discusses published experimental studies involving manipulation of the human brain serotonin system that included assessments of social behavior. To date, these studies have mostly been laboratory-based and included computer tasks, observations by others, or single-administration self-report measures. Most laboratory measures used so far inform about the role of serotonin in aspects of social interaction, but the relevance for real-life interaction is often unclear. Few studies have used naturalistic assessments in real life. We suggest several laboratory methods with high ecological validity as well as ecological momentary assessment, which involves intensive repeated measures in naturalistic settings. In sum, this commentary intends to stimulate experimental research on the neurobiology of human social interaction as it occurs in real life.

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“…

In the Introduction to this paper (Di Simplicio et al 2013) the authors incorrectly refer to Bigos et al (2008) among a number of previous studies consistently showing a decreased amygdala response to negative versus positive facial expressions after single-dose antidepressant administration in unselected healthy volunteers. Contrary to the other findings cited, Bigos et al (2008) found an increased amygdala response to facial expressions after acute citalopram administration.

Instead, Bigos et al (2008) should have been cited in the Limitations paragraph, a corrected version of which is displayed below.

Limitations

The results from this study are limited by the absence of a low-N control group also receiving SSRI treatment to verify that the effects seen here are specific to a highly neurotic sample.

…”

mentioning

confidence: 99%

“…In the Introduction to this paper (Di Simplicio et al 2013) the authors incorrectly refer to Bigos et al (2008) among a number of previous studies consistently showing a decreased amygdala response to negative versus positive facial expressions after single-dose antidepressant administration in unselected healthy volunteers. Contrary to the other findings cited, Bigos et al (2008) found an increased amygdala response to facial expressions after acute citalopram administration.…”

mentioning

confidence: 99%

Paradoxical effects of short-term antidepressant treatment in fMRI emotional processing models in volunteers with high neuroticism – CORRIGENDUM

Simplicio¹,

Norbury²,

Reinecke³

et al. 2013

Psychol. Med.

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In the Introduction to this paper (Di Simplicio et al. 2013) the authors incorrectly refer to Bigos et al. (2008) among a number of previous studies consistently showing a decreased amygdala response to negative versus positive facial expressions after single-dose antidepressant administration in unselected healthy volunteers. Contrary to the other findings cited, Bigos et al. (2008) found an increased amygdala response to facial expressions after acute citalopram administration.Instead, Bigos et al. (2008) should have been cited in the Limitations paragraph, a corrected version of which is displayed below. LimitationsThe results from this study are limited by the absence of a low-N control group also receiving SSRI treatment to verify that the effects seen here are specific to a highly neurotic sample. However, early effects of SSRI treatment on unselected (typically low-anxious) populations have been well replicated, with one exception using high-dose citalopram (20 mg i.v. compared to 20 mg oral administration) (Bigos et al. 2008). We also did not take a measure of drug plasma levels to ensure compliance and it is possible that the volunteers in this study did not all take citalopram as instructed, even though clear differences were apparent compared to placebo. Finally, in the absence of post-scan questionnaires verifying whether subjects were able to refrain from focusing on their thoughts during the ASL resting sequence, it possible that the two treatment groups engaged in different mental activities that might have been reflected in the amygdala perfusion differences.

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Paradoxical effects of short-term antidepressant treatment in fMRI emotional processing models in volunteers with high neuroticism

Cited by 63 publications

References 63 publications

A neurocognitive model for understanding treatment action in depression

A neurocognitive model for understanding treatment action in depression

Studying the neurobiology of human social interaction: Making the case for ecological validity

Paradoxical effects of short-term antidepressant treatment in fMRI emotional processing models in volunteers with high neuroticism – CORRIGENDUM

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