Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system

Arrieta, Óscar; Guevara, Patricia; Reyes, Sandra; Palencia, Guadalupe; Rivera, Erika; Sotelo, Julio

doi:10.1007/s004320100267

Cited by 9 publications

(5 citation statements)

References 20 publications

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“…Because of the increased risk for intratumoral hemorrhage, antiplatelet drugs may not be a good solution. Nevertheless, Arrieta et al 55 treated C6 glioma-bearing rats with acetylsalicylic acid (ASA) and found a reduction in tumor size after administration of low-dose ASA, although higher doses seemed paradoxically to promote tumor growth. Other groups have also investigated the influence of inhibitors of the arachidonic acid metabolism on tumor cell growth and migration.…”

Section: Discussionmentioning

confidence: 99%

Preoperative thrombocytosis predicts poor survival in patients with glioblastoma

Brockmann¹,

Giese²,

Mueller³

et al. 2007

Neuro-Oncology

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Background: Thrombocytosis is triggered by and promotes tumor growth. The relationship between the change in circulating platelets after chemoradiation therapy (CRT) or adjuvant temozolomide (TMZ) and survival in glioblastoma remains unclear. We hypothesized that an increase in platelets after these treatments would be predictive of a shorter survival. Methods: We retrospectively reviewed data on 122 patients with newly diagnosed, pathologically proven glioblastoma who had been treated with surgery, followed by CRT and adjuvant TMZ, from 2007 to 2016. The association between the changes in blood count levels and survival was analyzed by the log-rank test. To adjust for confounding, we performed a multivariate analysis using known prognostic co-variates. Results: Patients were dichotomized on the basis of the relative change in platelets after CRT from the baseline: ≤30% increase, low (n = 101) vs >30% increase, high (n = 12). The median survival for high vs. low platelets were 11 vs 28 months (p = 0.0062). No significant survival differences were observed on the basis of platelet changes during adjuvant TMZ. Similarly, changes in lymphocyte counts were not significantly prognostic. On multivariate analysis, MGMT, performance status, and an increase in platelets after CRT were significantly associated with survival (HR for platelets, 4.5; 95% confidence interval, 1.6-12.6). Conclusions: Increased platelet counts after CRT are predictive of poor survival in glioblastoma. The effect is platelet specific and does not reflect bone marrow changes, as lymphocyte changes were not significantly prognostic. These results suggest an interaction between platelets and tumor aggressiveness. Thus, platelets serve as a novel, minimally invasive liquid biopsy for predicting outcome.

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Section: Discussionmentioning

confidence: 99%

Preoperative thrombocytosis predicts poor survival in patients with glioblastoma

Brockmann¹,

Giese²,

Mueller³

et al. 2007

Neuro-Oncology

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“…This strongly indicates that the interplay of platelets and endothelial cells occurs in part via integrins mediating cell–cell adhesion. Paradoxical effects of platelet inhibition were reported by Arietta et al ., as high doses of ASA (200 or 400 mg/kg per day) increased tumor volume, cell proliferation, vascular density and mitotic index, while low doses (12.5 or 25 mg/kg per day) diminished tumor size in Wistar rats harboring glioma tumor grafts 164. However, it cannot be ruled out that ASA also had direct effects on tumor growth.…”

Section: The Role Of Platelets In Local Disease—tumor Growth and Tumomentioning

confidence: 97%

Tumor–platelet interaction in solid tumors

Buergy

Wenz

Groden

et al. 2012

Intl Journal of Cancer

316

283

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Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet count and prognosis of solid tumors, the following questions arise: (i) Are the increased platelet counts the reason for shortened survival as platelet-secreted cytokines might boost tumor growth and angiogenesis? (ii) Do platelets affect tumor metastasis thereby shortening survival time? or (iii) Are increased platelet counts simply an epiphenomenon of tumor growth with larger tumors resulting in higher platelet counts and shorter survival times? We address these three questions within our review of the current literature to provide a comprehensive overview of the current concepts in tumor-platelet interaction.

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“…83 As early as 1988, Farrell et al 84 reported an effect of ibuprofen on tumor weight at high and low doses in a C6 spheroid glioma implantation model. Arrieta et al 85 studied multiple doses of acetylsalicylic acid (ASA) ranging from 12.5 to 400 mg/kg per day on the growth of C6 glioma implanted subcutaneously. A paradoxical result was observed.…”

Section: Cox-2 Expression and Inhibition In Gliomamentioning

confidence: 99%

“…The authors concluded that at higher doses, ASA may block certain autocrine inhibitory factors dependent on the cyclooxygenase pathway, whereas at lower doses, mechanisms of apoptosis may be induced. 85 Malignant glioma also expresses an increased amount of thromboxane and prostaglandin. The capacity of arachidonic acid synthesis has been shown to directly correlate with the percentage of cells in the S phase in culture.…”

Section: Cox-2 Expression and Inhibition In Gliomamentioning

confidence: 99%

Cyclooxygenase in the Treatment of Glioma: Its Complex Role in Signal Transduction

New

2004

Cancer Control

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Paradoxical effect of aspirin on the growth of C6 rat glioma and on time of development of ENU-induced tumors of the nervous system

Cited by 9 publications

References 20 publications

Preoperative thrombocytosis predicts poor survival in patients with glioblastoma

Preoperative thrombocytosis predicts poor survival in patients with glioblastoma

Tumor–platelet interaction in solid tumors

Cyclooxygenase in the Treatment of Glioma: Its Complex Role in Signal Transduction

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