Paradoxic Relations between Basilar Artery Reconfiguration and Superior Cervical Ganglia Ischemia After Bilateral Common Carotid Artery Ligation

Kılıç, Mustafa; Kılıç, Betül; Aydın, Mehmet Dumlu; Kanat, Ayhan; Yılmaz, İlhan; Eşeoğlu, Metehan; Gündoğdu, Betül

doi:10.1016/j.wneu.2019.01.144

Cited by 14 publications

(10 citation statements)

References 25 publications

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“…So, TP is often used as a single parameter to detect cerebrovascular diseases, and it is difficult to monitor the complicated intracranial pathophysiological development after AIS. After AIS, the cerebral blood flow (CBF) decreases rapidly, and the CBF regulation will gradually intervene with the increase of time through cerebral arterial vasodilation and intravascular flow velocity rising [ 39 ]. According to the conductivity of biological tissues, the cerebrospinal fluid is the highest among intracranial contents, followed by the CBF, and the brain parenchyma is the lowest [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Early assessment of acute ischemic stroke in rabbits based on multi-parameter near-field coupling sensing

Shen

Jian

et al. 2022

BioMed Eng OnLine

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Background Early diagnosis and continuous monitoring are the key to emergency treatment and intensive care of patients with acute ischemic stroke (AIS). Nevertheless, there has not been a fully accepted method targeting continuous assessment of AIS in clinical. Methods Near-field coupling (NFC) sensing can obtain the conductivity related to the volume of intracranial components with advantages of non-invasiveness, strong penetrability and real-time monitoring. In this work, we built a multi-parameter monitoring system that is able to measure changes of phase and amplitude in the process of electromagnetic wave (EW) reflection and transmission. For investigating its feasibility in AIS detection, 16 rabbits were chosen to establish AIS models by bilateral common carotid artery ligation and then were enrolled for monitoring experiments. Results During the 6 h after AIS, the reflection amplitude (RA) shows a decline trend with a range of 0.69 dB and reflection phase (RP) has an increased variation of 6.48° . Meanwhile, transmission amplitude (TA) and transmission phase (TP) decrease 2.14 dB and 24.29° , respectively. The statistical analysis illustrates that before ligation, 3 h after ligation and 6 h after ligation can be effectively distinguished by the four parameters individually. When all those parameters are regarded as recognition features in back propagation (BP) network, the classification accuracy of the three different periods reaches almost 100%. Conclusion These results prove the feasibility of multi-parameter NFC sensing to assess AIS, which is promised to become an outstanding point-of-care testing method in the future.

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Section: Discussionmentioning

confidence: 99%

Early assessment of acute ischemic stroke in rabbits based on multi-parameter near-field coupling sensing

Shen

Jian

et al. 2022

BioMed Eng OnLine

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“…So, TP is often used as a single parameter to detect cerebrovascular diseases, and it is di cult to monitor the complicated intracranial pathophysiological development after AIS. After AIS, the cerebral blood ow (CBF) decreases rapidly, and the CBF regulation will gradually intervene with increased time through cerebral arterial vasodilation and intravascular ow velocity rising [36]. According to the electromagnetic properties of biological tissues, the cerebrospinal uid is the highest among intracranial contents, followed by the CBF, and the brain parenchyma is the lowest [37].…”

Section: Discussionmentioning

confidence: 99%

Early Assessment of Acute Ischemic Stroke in Rabbits Based on Multi-Parameter Near-Field Coupling Sensing

Shen

Jian

et al. 2021

Preprint

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Background: Maintaining normal supply of cerebral blood flow (CBF) and preventing secondary damage caused by acute ischemic stroke (AIS) are essential to the treatment of cerebrovascular diseases. Nevertheless, there hasn’t been fully accepted method targeting continuous assessment of AIS in clinical. Methods: Near-field coupling (NFC) sensing can obtain the electromagnetic properties related to the volume of intracranial components with advantages of noninvasiveness, strong penetrability and real-time monitoring. In this work, we built a multi-parameter monitoring system that is able to measure the phase and amplitude changes in electromagnetic wave reflection and transmission. For investigating its feasibility in AIS detection, sixteen rabbits were chosen to establish AIS models by bilateral common carotid artery ligation and then were enrolled for monitoring experiments.Results: During the six hours after AIS, the reflection amplitude (RA) shows a decline trend with a range of 0.69dB and reflection phase (RP) has an increased variation of 6.48°. Meanwhile, transmission amplitude (TA) and transmission phase (TP) decrease 2.14dB and 24.29° respectively. The statistical analysis illustrates that before ligation, three hours after ligation and six hours after ligation can be effectively distinguished by the four parameters individually. When all those parameters are regarded as recognition features in BP network, the classification accuracy of the three different periods reaches almost 100%.Conclusion: These results prove the feasibility of multi-parameter NFC sensing to assess AIS, which is promised to become an outstanding point-of-care testing method in the future.

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“…Hemodynamic insults at arterial bifurcations play an essential role in aneu-BCCAL results in histomorphological changes at the Circle of Willis (6). A paradoxical interrelation was explained by BA dilatation and degenerated neuron density of SCG after BCCAL (5). High neuron density of superior cervical ganglia prevents basilar dilatation after BCCAL (11) and aneurysm formation at the posterior circulatory arteries (12).…”

Section: Histopathological Findingsmentioning

confidence: 99%

“…Neurodegeneration of stellate ganglia may have a beneficial effect on the prevention of pulmonary artery spasm-related complications during steno-occlusive carotid artery disease (19). Although a higher neuron density in SCG may provoke excessive sympathetic activity and prevent excessive BA dilatation (5) and aneurysm formation in the posterior circulatory arteries (12,20). Sympathectomy also has the same useful effect on the same pathologies (11).…”

Section: Histopathological Findingsmentioning

confidence: 99%

“…Bilateral CCA occlusion results in redistribution of blood flow to posterior cerebral arteries with remarkable changes in morphology and perivascular nerve density, suggesting a functional role of perivascular nerves in cerebral autoregulation (4). A meaningful and paradoxical correlation was found between the values of the vasodilation index (VDI) of the basilar artery (BA) and the degenerated neuron density of the superior cervical ganglion (SCG) after BCCAL (5). We have shown that SCG ischemia has a positive effect on the development of recirculation after BCCAL.…”

Section: Introductionmentioning

confidence: 99%

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Bilateral Ortak Karotis Arter Ligasyonu Sonrası Kraniyofacioservikal Resirkülasyon Sırasında Trigeminal Ağ ve Karotiko-vertebrobaziler Vaskülatürü Arasındaki Sihirli İlişki: Ön Çalışma

Olgun

Demirtaş

Duman

et al. 2022

Batı Karadeniz Tıp Dergisi

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Aim: Steno-occlusive carotid artery disease causes increased intraluminal pressure, retrograde blood flow, intraluminal enlargement, vessel wall thinning, convolution, vascular remodelling, angiogenesis, and aneurysm formation. We investigated whether there is a relationship between trigeminal ganglion (TGG) ischemia and luminal surface area values of external/internal carotid arteries (ECA/ICA) after common carotid artery ligation (BCCAL). Material and Methods: This study was conducted in 20 hybrid male rabbits as control (GA;n=5), SHAM (GB;n=5), and study group (GC,n=10). Following anterior mid-cervical incision, permanent BCCAL was performed for only GC and animals sacrificed under general anaesthesia after three months. Degenerated neuron (DN) density of TGGs and ECAs/ICAs' luminal surface values were estimated by Cavalieri and Stereological methods. Lumen enlargement, wall thinning, elongation, convolution, and dolichoectasia were detected in the carotid artery vasculature. Results: The mean DN density of TGG was 12±4 in GA, 53±11 in GB, and 960±112 in GC. The mean number of ECA branches was calculated as 4±1/GA, 7±2/GB, and 11±3/GC. Total surface values of ECA/ICA (as mm2): 4.8±1.2/GA; 3.9±0.8/GB and 3.6±0.4/GC. Conclusion: The low density of DN in TGG could have a beneficial effect on neovascularization, collateral development, a renormalization of carotid circulation, and prevention of ischemic damage supplied by ECA/ICA of study group.

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Paradoxic Relations between Basilar Artery Reconfiguration and Superior Cervical Ganglia Ischemia After Bilateral Common Carotid Artery Ligation

Cited by 14 publications

References 25 publications

Early assessment of acute ischemic stroke in rabbits based on multi-parameter near-field coupling sensing

Early assessment of acute ischemic stroke in rabbits based on multi-parameter near-field coupling sensing

Early Assessment of Acute Ischemic Stroke in Rabbits Based on Multi-Parameter Near-Field Coupling Sensing

Bilateral Ortak Karotis Arter Ligasyonu Sonrası Kraniyofacioservikal Resirkülasyon Sırasında Trigeminal Ağ ve Karotiko-vertebrobaziler Vaskülatürü Arasındaki Sihirli İlişki: Ön Çalışma

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