2004
DOI: 10.3989/isegoria.2004.i31.462
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Paradojas de la filiación kantiana de Rawls

Abstract: RESUMEN. Innegable en algunos aspectos y en la voluntad declarada de Rawls, la cuestión nunca resuelta de la filiación kan" tiana de su obra no está exenta de conflictos, o mejor de situaciones paradójicas que, a nuestro entender, iluminan el sentido mismo de su obra. La raíz de esas paradojas parece descansar en que la tradición a la que obedece es la anglosajona y la éti-ca implícita de la que parte es la de un utilitarismo que nunca abandona del todo la expresión más externa y aparente de ese juego de parad… Show more

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“…AC", (26), our negative AC", values of binding may reflect the coalescence of the hydrophobic backbone of the ligand into the hydrophobic cleft of the kringle binding site, resulting in release of ordered water from both surfaces. The importance of hydrophobic groups in kringle-ligand binding was defincd by our mutagenesis studies (19,22,25,37), all of which indicated that a number of aromatic residues were essential for strong ligand binding. These primarily included a completely conserved tryptophan residue near position 61 (in [ K 1 pg] numbering), and another aromatic residue near 7 1.…”
Section: Discussionmentioning
confidence: 97%
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“…AC", (26), our negative AC", values of binding may reflect the coalescence of the hydrophobic backbone of the ligand into the hydrophobic cleft of the kringle binding site, resulting in release of ordered water from both surfaces. The importance of hydrophobic groups in kringle-ligand binding was defincd by our mutagenesis studies (19,22,25,37), all of which indicated that a number of aromatic residues were essential for strong ligand binding. These primarily included a completely conserved tryptophan residue near position 61 (in [ K 1 pg] numbering), and another aromatic residue near 7 1.…”
Section: Discussionmentioning
confidence: 97%
“…In addition to these ion-pair contacts, there are a number of interactions between the methylene backbone of the ligand and certain hydrophobic residues in the kringle binding sites. These hydrophobic residues are homologous to W60 and W70 of [ K~H P~] (19,22,25), especially the W70 position which has been shown to be particularly effective in determining the binding strength of the kringle.…”
Section: [ K~h P ]mentioning
confidence: 99%
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