Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

Dembitsky, Valery M.

doi:10.20546/ijcrbp.2017.412.002

Cited by 6 publications

(2 citation statements)

References 168 publications

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“…[(E)-6,6,6-trichloro-5-methylhex-2-enoic acid, 62)] from Dysidea (Dembitsky, 2017). (S)-7,7-Dichloro-3-hydroxy-2,2-dimethyloctanoic acid is incorporated into many lipopeptides predominantly in cyanobacteria like Lyngby sp.…”

Section: Lipidsmentioning

confidence: 99%

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Faleye,

Boya,

Lee

et al. 2023

Pharmacol Rev

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Antimicrobial resistance presents us with a potential global crisis as it undermines the abilities of conventional antibiotics to combat pathogenic microbes. The history of antimicrobial agents is replete with examples of scaffolds containing halogens. In this review, we discuss the impacts of halogen atoms in various antibiotic types and antimicrobial scaffolds and their modes of action, structure-activity relationships, and the contributions of halogen atoms in antimicrobial activity and drug resistance. Other halogenated molecules, including carbohydrates, peptides, lipids, and polymeric complexes, are also reviewed, and the effects of halogenated scaffolds on pharmacokinetics, pharmacodynamics, and factors affecting antimicrobial and antivirulence activities are presented. Furthermore, the potential of halogenation to circumvent antimicrobial resistance and rejuvenate impotent antibiotics is addressed. This review provides an overview of the significance of halogenation, the abilities of halogens to interact in biomolecular settings and enhance pharmacological properties, and their potential therapeutic usages in preventing a post-antibiotic era. Significance StatementAntimicrobial resistance and the increasing impotence of antibiotics are critical threats to global health. The roles and importance of halogen atoms in antimicrobial drug scaffolds have been established, but comparatively little is known of their pharmacological impacts on drug resistance and antivirulence activities. This review is the first to extensively evaluate the roles of halogen atoms in various antibiotic classes and pharmacological scaffolds and to provide an overview of their abilities to overcome antimicrobial resistance.

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Section: Lipidsmentioning

confidence: 99%

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Faleye,

Boya,

Lee

et al. 2023

Pharmacol Rev

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“…[40] Three 5,6-epoxy secosterols were found in soft coral Lobophytum sp. (13) [41] and sponge Aplysilla glacialis (14 and 15), [42] respectively. Both sekosterols (14 and 15) isolated from the sponge showed anticancer activity.…”

Section: Steroids Bearing 56-epoxy Groupmentioning

confidence: 99%

Naturally occurring marine α,β‐epoxy steroids: Origin and biological activities

Dembitsky

Gloriozova

Poroikov

2018

Vietnam Journal of Chemistry

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The present review describes the biological activities of more than 100 marine α,β‐epoxy steroids. These steroids have been isolated from marine invertebrates including, sponges, starfish, soft corals and nudibranch (Mollusca). We used the computer program PASS and based on structure‐activity relationships (SAR), which contains more than one million chemical compounds and more than 8,000 biological activities. The most frequently predicted activities are anti‐neoplastic, anti‐inflammatory, anti‐fungal and other activities are identified with a certainty of 76 to 94 percent. The main activities for different groups of steroids differ significantly.

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Peroxy steroids derived from plant and fungi and their biological activities

Vil

Gloriozova

Poroikov

et al. 2018

Appl Microbiol Biotechnol

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Peroxides represent a large and interesting group of biologically active natural compounds. All these metabolites contain a peroxide group (R-O-O-R). This review describes studies of more than 60 peroxides isolated from plants and fungi. Most of the plant peroxy steroids exhibit high antiprotozoal (Plasmodium) activity with a confidence of up to 95%, while steroids harvested from fungi show more antineoplastic activity with a confidence of up to 94%. In addition, more than 20 different activities of both groups of peroxides with a probability of 78 to 90% have also been predicted using computer program PASS.

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Paradigm Shifts in Fungal Secondary Metabolite Research: Unusual Fatty Acids Incorporated into Fungal Peptides

Cited by 6 publications

References 168 publications

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Halogenated Antimicrobial Agents to Combat Drug-Resistant Pathogens

Naturally occurring marine α,β‐epoxy steroids: Origin and biological activities

Peroxy steroids derived from plant and fungi and their biological activities

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