Paradigm shift in the risk assessment of cumulative effects of pesticide mixtures and multiple residues to humans and wildlife: German proposal for a new approach

Solecki, Roland; Stein, Bernd; Frische, Tobias; Matezki, Steffen; Wogram, Jörn; Streloke, Martin

doi:10.1007/s00003-014-0914-8

Cited by 14 publications

(11 citation statements)

References 2 publications

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“…An overview of the German Guidance is given in ''Assessment of the risks resulting from exposure to pesticide mixtures and multiple pesticide residues to humans and wildlife'' (Solecki et al 2014). It is intended to inform interested experts from industry, academia, regulatory bodies and NGOs about the current status of the implementation of mixture risk assessment from the perspectives of human health risk assessment, environmental risk assessment and risk management, which are interrelated elements for the implementation of cumulative…”

Section: Discussionmentioning

confidence: 99%

Human health risk assessment from combined exposure in the framework of plant protection products and biocidal products

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Human health risk assessment from combined exposure in the framework of plant protection products and biocidal products

et al. 2014

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“…These include products containing more than one defined chemical component (intentional mixtures), products comprising a complex mixture of chemicals, not all of which are defined (intentional mixtures of Unknown or Variable composition, Complex reaction products or Biological materials, UVCBs), and exposure to multiple chemicals from different products (incidental or unintentional mixtures). An agreed and sufficiently specific and applicable technical guidance is needed to facilitate a consistent and adequate implementation of a harmonized approach for risk assessment of combined exposure to multiple chemicals via multiple routes (Solecki et al 2014). Various frameworks on this type of risk assessment have been proposed or are actively being developed by European or international organisations, such as the European Food Safety Authority (EFSA), the World Health Organisation (WHO), the International Programme on Chemical Safety (IPCS) and the Organisation for Economic Cooperation and Development (OECD) (reviewed in Kienzler et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution

Rotter

Beronius

Boobis

et al. 2018

Critical Reviews in Toxicology

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This article reviews the current legislative requirements for risk assessment of combined exposure to multiple chemicals via multiple exposure routes, focusing on human health and particularly on foodrelated chemicals. The aim is to identify regulatory needs and current approaches for this type of risk assessment as well as challenges of the implementation of appropriate and harmonized guidance at international level. It provides an overview of the current legal requirements in the European Union (EU), the United States and Canada. Substantial differences were identified in the legal requirements for risk assessment of combined exposure to multiple chemicals and its implementation between EU and non-EU countries and across several regulatory sectors. Frameworks currently proposed and in use for assessing risks from combined exposure to multiple chemicals via multiple routes and different durations of exposure are summarized. In order to avoid significant discrepancies between regulatory sectors or countries, the approach for assessing risks of combined exposure should be based on similar principles for all types of chemicals. OECD and EFSA identified the development of harmonized methodologies for combined exposure to multiple chemicals as a key priority area. The Horizon 2020 project "EuroMix" aims to contribute to the further development of internationally harmonized approaches for such risk assessments by the development of an integrated test strategy using in vitro and in silico tests verified for chemical mixtures based on more appropriate data on potential combined effects. These approaches and testing strategies should be integrated in a scientifically based weight of evidence approach to account for complexity and uncertainty, to improve risk assessment.

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“…For example, the US EPA has risk assessment programs in the area of mixtures toxicology in the Office of Water, the Office of Air and Radiation, Superfund, and the Office of Research and Development’s National Center for Environmental Assessment (Sexton, 2012; US EPA, 2015). In addition, many international health agencies have either recently established or are actively developing cumulative risk assessment guidelines (Boobis et al, 2008; Health Canada, 2016; RIVM, 2016; Solecki et al, 2014). …”

Section: Introductionmentioning

confidence: 99%

Cumulative effects of antiandrogenic chemical mixtures and their relevance to human health risk assessment

Howdeshell

Hotchkiss

Gray

2017

International Journal of Hygiene and Environmental Health

107

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Toxicological studies of defined chemical mixtures assist human health risk assessment by establishing how chemicals interact with one another to induce an effect. This paper reviews how antiandrogenic chemical mixtures can alter reproductive tract development in rats with a focus on the reproductive toxicant phthalates. The reviewed studies compare observed mixture data to mathematical mixture model predictions based on dose addition or response addition to determine how the individual chemicals in a mixture interact (e.g., additive, greater, or less than additive). Phthalate mixtures were observed to act in a dose additive manner based on the relative potency of the individual phthalates to suppress fetal testosterone production. Similar dose additive effects have been reported for mixtures of phthalates with antiandrogenic pesticides of differing mechanisms of action. Overall, data from these phthalate experiments in rats can be used in conjunction with human biomonitoring data to determine individual hazard indices, and recent cumulative risk assessments in humans indicate an excess risk to antiandrogenic chemical mixtures that include phthalates only or phthalates in combination with other antiandrogenic chemicals.

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Paradigm shift in the risk assessment of cumulative effects of pesticide mixtures and multiple residues to humans and wildlife: German proposal for a new approach

Cited by 14 publications

References 2 publications

Human health risk assessment from combined exposure in the framework of plant protection products and biocidal products

Human health risk assessment from combined exposure in the framework of plant protection products and biocidal products

Overview on legislation and scientific approaches for risk assessment of combined exposure to multiple chemicals: the potential EuroMix contribution

Cumulative effects of antiandrogenic chemical mixtures and their relevance to human health risk assessment

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