“…(6, 8) To this end, a relevant shift in the surgical management of the disease and the choice of material for cranioplasty has been already initiated, SF are increasingly replacing ABF for cranioplasties. (5,6,13,22,23) To date, we are aware that younger age, traumatic brain injury, reimplantation of multiple bone fragments and surgical site infection are well established prognostic factors for development of aseptic bone necrosis. (3,4,16,17) The subsequent bone lysis may in turn initiate issues regarding cosmesis, protection, cranioplasty failure and reoperation as well as to rare situations, like sinking skin syndrome.…”