Paracrine Effects of Cell Transplantation: Strategies to Augment the Efficacy of Cell Therapies

The Regenerative Medicine Laboratory: Facilitating Stem Cell Therapy for Equine Disease

“…Recent evidence suggests that preconditioning of MSCs may enhance their survival and, as a result, enhance their regenerative and immunomodulating properties [6,7]. In fact, research efforts within the field of regenerative therapy have been dedicated to understanding the in vitro manipulation of cells prior to transplantation, in an attempt to maximize their biologic and functional properties [8,9].…”

Possible mechanisms of retinal function recovery with the use of cell therapy with bone marrow-derived stem cells

“…Evidence also exists that both endogenous and exogenous stem cells are able to "home" or migrate into the area of injury from the site of injection or infusion (26,30,(32)(33)(34)(35)(36)(37)(38) . MSC in the bone marrow can be mobilized, target the areas of infarction, and differentiate into target tissue type.…”

“…Fourth, stem cell transplantation alters the extracellular matrix, resulting in more favorable post-infarct remodeling, strengthening of the infarct scar, and prevention of deterioration in organ function (34)(35)(36)(37) . Acute human and murine MSC infusion prior to ischemia improve myocardial developed pressure, contractility, and compliance after ischemia/reperfusion (I/R) injury and decrease end diastolic pressure.…”

“…Recent work demonstrated the existence of endogenous, stem cell-like populations in adult heart, liver, brain, and kidney (33)(34)(35)(36)(37)(38)(39) . These resident stem cells may possess growth factor receptors that can be activated to induce their migration and proliferation and promote both the restoration of dead tissue and the improved function in damaged tissue.…”

“…Improved understanding of these paracrine mechanisms may allow earlier and more effective clinical therapies (25,(36)(37) .…”