Paracoccidioidomycosis in patients with human immunodeficiency virus: review of 12 cases observed in an endemic region in Brazil

Paniago, Anamaria Mello Miranda; Freitas, Ana Carolina Carli de; Aguiar, Eliana Setti Albuquerque; Aguiar, José Ivan; Cunha, Rivaldo Venâncio da; Motta-Castro, Ana Rita Coimbra; Wanke, Bodo

doi:10.1016/j.jinf.2005.01.010

Cited by 67 publications

(65 citation statements)

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“…In a series of coinfected patients in which a small number of patients were assessed with serological tests for anti-P. brasiliensis antibodies, false-negative results were obtained in 33% (Paniago et al 2005) and 66% (Marques et al 1995) of the serum samples. The use of CIEP or ELISA increased the rate of reactive sera; however, in both tests the low levels of anti-P. brasiliensis in some HIV-infected patients were insufficient for a safe serological diagnosis of paracoccidioidomycosis because of cross-reactions and specificity lower than 100% (de Camargo 2008).…”

Section: Discussionmentioning

confidence: 99%

Serological diagnosis of paracoccidioidomycosis in HIV-coinfected patients

Bellissimo-Rodrigues¹,

Vitali²,

Martínez

2010

Mem. Inst. Oswaldo Cruz

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Paracoccidioidomycosis should be differentiated from other opportunistic diseases in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients who live in Latin America. Laboratory investigation can begin with serological tests, which are rapid and efficient. In the present study, double immunodiffusion (DID), counterimmunoelectrophoresis (CIEP) and an enzyme linked immunosorbent assay (ELISA) tests were assessed for the detection of anti-Paracoccidioides brasiliensis antibodies in 40 patients coinfected with HIV. The results were compared to those obtained for 75 non-HIV-infected patients with endemic paracoccidioidomycosis. Anti-P. brasiliensis antibodies were detected in 65% (DID), 79% (CIEP) and 95% (ELISA) of the patients with HIV/AIDS, significantly lower rates than those detected in cases of endemic paracoccidioidomycosis, which were 89%, 99% and 100%, respectively. The reactive sera of HIV-infected patients also showed lower anti-P. brasiliensis antibody titres than those of non-HIV-infected patients. Despite the lower intensity of the specific humoral response, serological tests are useful for the diagnosis of opportunistic paracoccidioidomycosis in the HIV/AIDS population. We suggest optimization of the laboratory diagnosis by combining the ELISA test with CIEP or DID

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Section: Discussionmentioning

confidence: 99%

Serological diagnosis of paracoccidioidomycosis in HIV-coinfected patients

Bellissimo-Rodrigues¹,

Vitali²,

Martínez

2010

Mem. Inst. Oswaldo Cruz

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“…Los profesionales de la salud bucal y bucofacial deben ahora tomar en cuenta la posibilidad de la presencia de una enfermedad micótica sistémica al observar ulceraciones crónicas, infección crónica de los senos maxilares, o lesiones bucales idiopáticas e inusuales, sobre todo en pacientes VIH+, con desórdenes linfoproliferativos o diabéticos, o también en aquellos que viven en áreas endémicas. El diagnóstico y manejo clínico de los pacientes con lesiones micóticas sistémicas debe ser hecho multidisciplinariamente ya que pueden estar involucrados los pulmones y otros órganos importantes además de la cavidad bucal (10).…”

Section: Características Clínicasunclassified

Paracoccidioidomicosis en cavidad oral

et al. 2012

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Paracoccidioidomicosis en cavidad oral RESUMENLa paracoccidioidomicosis (PCM) o blastomicosis suramericana es la micosis sistémica más importante de América latina que es relativamente común en Brasil, Venezuela, Colombia, Ecuador y Argentina. Los casos esporádicos también pueden verse en algunos otros países, la cual es progresiva y con un infrecuente desenlace fatal si no es tratada a tiempo. Se considera como una enfermedad multifocal, con lesiones orales como la característica prominente. Es causada por un hongo dimórfico, Paracoccidioides brasiliensis, que afecta principalmente la piel, los ganglios linfáticos, los pulmones y membranas mucosas oral, nasal y gastrointestinal. Dependiendo de la inmunidad específica del huésped, la infección puede asumir muchas formas y afecta a uno o varios órganos, llegando a ser una enfermedad grave y potencialmente fatal. Es muy importante para los profesionales de la salud de todo el mundo tener conocimiento acerca de la Paracoccidioidomicosis porque a veces la enfermedad sólo se manifiesta muchos años después de que haya abandonado la zona endémica. Para proporcionar información útil sobre el diagnóstico y tratamiento de la enfermedad se presenta caso clínico de un paciente masculino de 48 años de edad procedente de una zona rural de Juramento Brasil, por presentar múltiples úlceras dolorosas en encía y paladar de 3 meses de evolución; refiere antecedentes de fumador crónico, al examen clínico extraoral se descartan lesiones en otros órganos y al examen intraoral se observan múltiples úlceras con fondo necrótico y granulomatoso localizadas en encía y paladar. Se realizó una biopsia incisional de la lesión y el material fue enviado para estudio anatomopatológico. El informe histopatológico confirmó la impresión clínica de Paracoccidioidomicosis. El paciente fue tratado con el uso de sulfametoxazol + trimetoprima -800/60 mg/día, vía oral, cada 12 horas durante 30 días. Las lesiones bucales desaparecieron completamente y el paciente continúa bajo control en el servicio.Palabras clave: Paracoccidioidomicosis, blastomicosis suramericana, enfermedad micótica. SUMMARYParacoccidioidomycosis (PCM) or South-american Blastomycosis is the most important systemic mycosis in Latin America, is relatively common in Brazil, Venezuela, Colombia, Ecuador and Argentina. Sporadic cases can also be seen in some other countries, which is a rare progressive and fatal if not treated. It has been regarded as a multifocal disease with oral lesions as the prominent feature. It is caused by a dimorphic fungus, Paracoccidioides brasiliensis, which mainly affects the skin, lymph nodes, lungs and mucous membranes, oral, nasal and gastrointestinal. Depending on the specific immunity of the host, the infection can take many forms Paracoccidioidomicosis en cavidad oral

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“…Bone involvement is an important component of juvenile form and is observed in 45% of patients, with predominant lesions in the upper limbs and ribs [13] [19] [20] [21]. progression of the disease occurs accompanied by fever, lymphatic involvement, mucosal lesions and hepatosplenomegaly [7] [22] [23].…”

Section: Introductionmentioning

confidence: 99%

Ulcerated Lesion in Buccal Mucosa in a Patient with Paracoccidioidomycosis—Case Report

Vaz¹,

Pino²,

Costa³

et al. 2017

JBM

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Paracoccidioidomycosis is the most prevalent systemic mycosis in Latin America. It is a fungal infection caused by the dimorphic fungus Paracoccidioides brasiliensis. This microorganism can penetrate the human body through direct contact and can cause intense lymphadenopathy, ulcerated lesions in the oral cavity and in the skin among other alterations. In this study, we report a case of paracoccidioidomycosis with unusual clinical presentation, as it manifested in the female sex and although it did not present any relevant complaints of respiratory focus, it presented a single ulcerated lesion in the buccal mucosa. A biopsy of the lesion and a mycological examination revealed Paracoccidioides brasiliensis infection.

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Paracoccidioidomycosis in patients with human immunodeficiency virus: review of 12 cases observed in an endemic region in Brazil

Cited by 67 publications

References 12 publications

Serological diagnosis of paracoccidioidomycosis in HIV-coinfected patients

Serological diagnosis of paracoccidioidomycosis in HIV-coinfected patients

Paracoccidioidomicosis en cavidad oral

Ulcerated Lesion in Buccal Mucosa in a Patient with Paracoccidioidomycosis—Case Report

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