Paracoccidioidomicose no Hospital Universitário de Brasília

Campos, Maria Vitoria Silva; Penna, Gerson Oliveira; Castro, Cleudson; Moraes, Mário Augusto Pinto de; Ferreira, Marcelo Simão; Santos, João Barberino

doi:10.1590/s0037-86822008000200007

Cited by 27 publications

(18 citation statements)

References 17 publications

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“…The predominance of male patients is consistent with findings from studies that found male-to-female ratios between 5:1 to 16.3:1 in Mato Grosso do Sul, Brasília, São Paulo and Rio Grande do Sul (Londero and Ramos, 1990; Blotta et al , 1999; Paniago et al , 2003; Shikanai-Yasuda et al , 2006; Campos et al , 2008). This difference may be explained by a hormone protective factor in women.…”

Section: Discussionsupporting

confidence: 89%

Paracoccidioidomycosis in southern Rio Grande do Sul: a retrospective study of histopathologically diagnosed cases

Souza¹,

Jorge²,

Xavier

2014

Braz. J. Microbiol.

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Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the fungus Paracoccidioides brasiliensis and is endemic to Brazil. The aim of this study was to perform a retrospective analysis of the PCM cases in the countryside south of Rio Grande do Sul, Brazil. The files from four histopathology laboratories located in the city of Pelotas were obtained, and all of the epidemiological and clinical data from the PCM diagnosed cases were collected for analysis. A total of 123 PCM cases diagnosed between 1966 and 2009 were selected. Of these patients, 104 (84.5%) were male, and 17 were female. The patients ranged from 02 to 92 years of age. Fifty-two cases (41.9%) were obtained from the oral pathology laboratory, and the remaining 71 cases (58.1%) were obtained from the three general pathology laboratories. Of all of the patients studied, 65.2% lived in rural zones and worked in agriculture or other related fields. Data on the evolution of this disease was available for 43 cases, and the time frame ranged from 20 to 2920 days (mean = 572.3 days). An accurate diagnosis performed in less than 30 days only occurred in 21% of the cases. PCM is endemic to the countryside of Rio Grande do Sul. Therefore, it is recommended that PCM be included as a differential diagnosis, mainly for individuals between 30 and 60 years of age, living in rural zones and who have respiratory signs and associated-oropharyngeal lesions.

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Section: Discussionsupporting

confidence: 89%

Paracoccidioidomycosis in southern Rio Grande do Sul: a retrospective study of histopathologically diagnosed cases

Souza¹,

Jorge²,

Xavier

2014

Braz. J. Microbiol.

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“…The proportion of acute/subacute cases in our series was similar to that referenced in other publications 3,12,19,20 and the main signs and symptoms had similar frequencies to those observed in other series. 14,17,21,22 Skin lesions were found at a higher frequency in our population than in other series. 14,17 These lesions arouse a high degree of disease suspicion, and because they offered easy access to direct examination and biopsy, they significantly contributed to the diagnosis.…”

Section: Discussioncontrasting

confidence: 51%

“…9 Alcohol use was reported by 57.5% of the 341 patients surveyed, a proportion close to the 55.3% reported at Hospital Universitário de Brasília. 17 In addition to the effects of alcohol on a patient's immune response , 18 the lack of compliance to treatment by alcoholic patients was also noteworthy.…”

Section: Discussionmentioning

confidence: 99%

Paracoccidioidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied in the State of Espírito Santo, Brazil

Peçanha

Ferreira

Peçanha

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Paracoccidioidomycosis (PCM) is an endemic disease in the southeast region of Brazil, which includes the state of Espírito Santo (ES). This historic case series analyses 546 patients treated in this state from 1978 to 2012. Patients aged from 7 to 83 years, 509 males and 37 females, yielding a ratio of 13.7:1. Most of the patients (81.4%) originated from rural areas in ES, 71.0% being farmers. A higher concentration of cases was observed in municipalities located along the western range of the state. Sixty patients (11.0%) had an acute/subacute form of the disease, 485 (88.9%) had a chronic form, and one had a subclinical form. The most affected organs included the lungs, oropharyngeal mucosa, lymph nodes, skin, and larynx. The diagnosis was confirmed by histopathology in 252 (46.2%) cases, direct examination in 168 (30.7%), both exams in 111 (20.3%) and serology in 15 (2.8%). Tuberculosis, acquired immune deficiency syndrome, leishmaniasis, and intestinal parasites were the most frequently associated infectious diseases. From 328 patients followed up, total regression of the lesions was observed in 17.4%, partial regression in 77.4%, and no regression in 17 (5.2%) cases. Regarding the number of cases in this series, ES emerges as an important endemic area for PCM in Brazil.

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“…In the current study, the predominance of NPCM in men was 13/1, and is in accordance with previous reports 7,11,20,[29][30][31] . In some studies, NPCM occurred exclusively in men 10,32 .…”

Section: Discussionsupporting

confidence: 93%

“…Soil is the main natural source for infectious airborne conidia and people living in rural areas are the main population at risk 8 . In this study, occupational activity related to soil was present in 58% of cases, in accordance with previous reports 10,20,[30][31][32]35,36 although this information could be underestimated due to lack of appropriate investigation during anamnesis. Occasional non-autochthonous cases of PCM have been reported outside Latin America 37 .…”

Section: Discussionsupporting

confidence: 92%

Autopsy and biopsy study of paracoccidioidomycosis and neuroparacoccidioidomycosis with and without HIV co‐infection

Almeida

Roza

Salvador

et al. 2018

Mycoses

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Paracoccidioidomycosis (PCM) is a systemic mycosis prevalent among immunocompetent patients in Latin America. This study aimed to describe the frequency, demographics and clinical characteristics of central nervous system PCM (NPCM) and PCM in an endemic region, and the impact of human immunosuppression virus (HIV) co-infection. This was a retrospective study of autopsy and biopsy reports from the Medical Pathology Section of the Hospital de Clinicas, UFPR, Curitiba, Southern Brazil, between 1951 and 2014. PCM was present in 0.1% of 378,323 cases examined, with 5.7% being NPCM. Infection was prevalent in working-age men, agricultural workers and rural residents. Numbers of HIV autopsy cases increased over time, while those of PCM cases decreased. Prevalence of co-infection of HIV/PCM and HIV/NPCM was 1.6%, and 0.4%, respectively. Adrenals were affected more frequently in the NPCM group compared with the PCM group. Mortality was higher on NPCM group. The clinical course of PCM in HIV patients resembles an acute/sub-acute infection. Association of NPCM and HIV is rare, while diagnosis of NPCM is difficult, it should be considered a differential diagnosis in HIV patients who live in, or have visited, endemic areas and present with neurological symptoms.

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Paracoccidioidomicose no Hospital Universitário de Brasília

Cited by 27 publications

References 17 publications

Paracoccidioidomycosis in southern Rio Grande do Sul: a retrospective study of histopathologically diagnosed cases

Paracoccidioidomycosis in southern Rio Grande do Sul: a retrospective study of histopathologically diagnosed cases

Paracoccidioidomycosis: Epidemiological and Clinical Aspects in 546 Cases Studied in the State of Espírito Santo, Brazil

Autopsy and biopsy study of paracoccidioidomycosis and neuroparacoccidioidomycosis with and without HIV co‐infection

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