Parachordoma: A Case Report

Šeparović, Robert; Glumbić, Ivana; Pigac, Biserka; Šeparović, Viktor; Krušlin, Božo

doi:10.1177/030089160108700318

Cited by 8 publications

(4 citation statements)

References 13 publications

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“…The term parachordoma was coined by Dabska 26 years later, 2 when she described in detail the features of 10 cases (including the five cases reported by Laskowski). Since this time less than 40 cases have been reported, about half of which have included details of immunohistochemistry 2–23 . The reported tumors have been nearly twice as common in men than women and the ages of those affected ranged from 4 to 86 years (mean, 32 years).…”

Section: Discussionmentioning

confidence: 99%

“…Rarely, tumors with a similar morphology might involve peripheral sites and such tumors may cause difficulties in the diagnosis. While their most frequent designation is parachordoma, such tumors have also been described under a variety of names, all of which imply a similarity to chordoma 2–23 . Recently, however, Nielsen and colleagues suggested that rather than representing one tumor, there are two distinct chordoma‐like tumors of the periphery: chordoma periphericum and parachordoma 15 .…”

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Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Scolyer

Bonar

Palmer³

et al. 2004

Pathology International

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Parachordoma is a rare soft tissue tumor that morphologically resembles chordoma of the axial skeleton but occurs in a peripheral site. A recent study reported immunohistochemical differences between chordoma and parachordoma. While both tumors were positive for cytokeratin (CK) 8/18 (as recognized by the antibody Cam5.2), S100 and epithelial membrane antigen (EMA), only the chordoma was positive for CK7, CK20, CK 1/5/10/14 (as recognized by the antibody 34betaE12) and carcinoembryonic antigen (CEA). It has since been suggested that tumors indistinguishable from chordoma that involve the periphery should be termed chordoma periphericum and that these tumors are distinct from parachordoma. In the current study, the clinical, radiological, pathological, immunohistochemical and ultrastructural features of a chordoma-like tumor involving the deep soft tissues of the lower leg of a 69-year-old woman are presented. Microscopically, the tumor had a pseudolobulated growth pattern and consisted of sheets, nests and cords of epithelioid cells, some with a physaliferous appearance, separated by abundant myxoid stroma. The tumor cells were positive for CK 8/18, EMA and S100, showed focal staining for CK7, and were negative for CK20, CK 1/5/10/14 and CEA. On the basis of these results a diagnosis of parachordoma was favored. For comparison, an immunohistochemical analysis of five axial chordomas was also performed. The chordomas showed positivity for CK 8/18 (5 of 5 cases), EMA (5 of 5 cases), S100 (5 of 5 cases), CK 1/5/10/14 (1 of 5 cases) and CK7 (1 of 5 cases). Stains for CK20 and CEA were negative in all five chordomas. The results of the present study suggest that the expression of antigens for CK 1/5/10/14, CK7, CK20 and CEA in chordoma might not be as common as what has been previously reported. The results also suggest that parachordoma might not be easily distinguished immunohistochemically from axial chordoma (and therefore also from so-called chordoma periphericum).

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Scolyer

Bonar

Palmer³

et al. 2004

Pathology International

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“…The nuclei of the neoplastic cells are hyperchromatic with inconspicuous nucleoli, surrounded by clear, vacuolated, or eosinophilic cytoplasm. 28,32 As with the conventional chondrosarcoma, immunohistochemistry is helpful in most cases. Extraskeletal myxoid chondrosarcoma is positive for vimentin and S-100 protein but is usually negative for cytokeratins.…”

Section: Discussionmentioning

confidence: 99%

Parachordoma or chordoma periphericum? Case report of a tumor of the thoracic wall

Tong

Perle

Desai

et al. 2003

Diagnostic Cytopathology

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We report the findings from an aspiration biopsy and resection of a chordoma-like tumorous mass in the wall of the thorax of a 36-yr-old man with immunohistochemical, ultrastructural, and cytogenetic studies. The 4-cm oval tumor was an incidental finding on physical examination, and no other lesions were identified after comprehensive radiologic studies. The aspirate was composed of sheets and nests of cells with distinct borders in a myxoid and fibrillary extracellular matrix. The neoplastic cells were uniform and round or polygonal with abundant pale blue vacuolated cytoplasm and small round, central or eccentric nuclei. On electron microscopy, mitochondrial rough endoplasmic reticulum complexes were seen in neoplastic cells. These features were similar to those of a conventional chordoma. However, the cytogenetic pattern, 43, XY ,-1, -2, der (5)t(1p;5q), -6, add(8p) ,add(10q), was not typical. In addition, the neoplastic cells were positive for vimentin, S-100, AE1/AE3, CAM 5.2, and CK 19; were focally positive for EMA and smooth muscle actin; and were negative for cytokeratin 1 and 10 (34 beta E12), CK 7, CK 8 (35H 11B), CK 17, and CK 20. The cytogenetic and immunohistochemical patterns were different from conventional chordoma and its peripheral counterpart, chordoma periphericum, suggesting the diagnosis of parachordoma. To the best of our knowledge, this is the first report of fine-needle aspiration of this newly defined and rare entity.

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“…Komparativni primjerak nađen je na lokalitetu Asserie i datira se u II stoljeće. 310 U poseban tip spadaju i tri primjerka bocebalzamarija (Tab. 26, 4 i 5 i Tab.…”

Section: Staklounclassified

Rimski medicinski, veterinarski i farmaceutski instrumenti, kozmetička i ženska lična oprema iz zbirke Zemaljskog muzeja Bosne i Hercegovine

Busuladžić¹

2016

God. - Akad. nauka umjet. Bosne Herceg., Cent. balk. ispit.

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Among the archaeological objects from the Roman period kept in Bosnia and Herzegovina, there are some that belong to the group of medical, pharmaceutical and veterinary implements, as well as those used as cosmetic accessories. Part of the objects kept in the collection of the National Museum of Bosnia and Herzegovina came through acquisitions and gi s, and they originate from territories of Greece, Albania and Croatia. However, major part of the collection make objects obtained through archaeological research works. Analysis of the presented objects shows that all the then known curative methods in medicine, as well as cosmetic accessories when fashion trends are in question, were also used in the inner parts of the Roman province of Dalmatia.

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Parachordoma: A Case Report

Cited by 8 publications

References 13 publications

Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Parachordoma or chordoma periphericum? Case report of a tumor of the thoracic wall

Rimski medicinski, veterinarski i farmaceutski instrumenti, kozmetička i ženska lična oprema iz zbirke Zemaljskog muzeja Bosne i Hercegovine

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