Parachordoma

Shin, Hyung Ju C.; Mackay, Bruce; Ichinose, Herbert; Ayala, Alberto G.; Romsdahl, Marvin M.

doi:10.3109/01913129409016297

Cited by 27 publications

(12 citation statements)

References 10 publications

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“…The term parachordoma was coined by Dabska 26 years later, 2 when she described in detail the features of 10 cases (including the five cases reported by Laskowski). Since this time less than 40 cases have been reported, about half of which have included details of immunohistochemistry 2–23 . The reported tumors have been nearly twice as common in men than women and the ages of those affected ranged from 4 to 86 years (mean, 32 years).…”

Section: Discussionmentioning

confidence: 99%

“…Early reports suggested that parachordoma was related to axial chordoma and that it might arise from aberrantly located notochordal rests, 12 but a number of recent studies have highlighted immunohistochemical, ultrastructual and cytogenetic differences between the two tumors 3,7 , 15,25 . On the basis of the results of these studies it has been proposed that parachordoma is distinct from chordoma.…”

Section: Discussionmentioning

confidence: 99%

“…Rarely, tumors with a similar morphology might involve peripheral sites and such tumors may cause difficulties in the diagnosis. While their most frequent designation is parachordoma, such tumors have also been described under a variety of names, all of which imply a similarity to chordoma 2–23 . Recently, however, Nielsen and colleagues suggested that rather than representing one tumor, there are two distinct chordoma‐like tumors of the periphery: chordoma periphericum and parachordoma 15 .…”

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Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Scolyer

Bonar

Palmer³

et al. 2004

Pathology International

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Parachordoma is a rare soft tissue tumor that morphologically resembles chordoma of the axial skeleton but occurs in a peripheral site. A recent study reported immunohistochemical differences between chordoma and parachordoma. While both tumors were positive for cytokeratin (CK) 8/18 (as recognized by the antibody Cam5.2), S100 and epithelial membrane antigen (EMA), only the chordoma was positive for CK7, CK20, CK 1/5/10/14 (as recognized by the antibody 34betaE12) and carcinoembryonic antigen (CEA). It has since been suggested that tumors indistinguishable from chordoma that involve the periphery should be termed chordoma periphericum and that these tumors are distinct from parachordoma. In the current study, the clinical, radiological, pathological, immunohistochemical and ultrastructural features of a chordoma-like tumor involving the deep soft tissues of the lower leg of a 69-year-old woman are presented. Microscopically, the tumor had a pseudolobulated growth pattern and consisted of sheets, nests and cords of epithelioid cells, some with a physaliferous appearance, separated by abundant myxoid stroma. The tumor cells were positive for CK 8/18, EMA and S100, showed focal staining for CK7, and were negative for CK20, CK 1/5/10/14 and CEA. On the basis of these results a diagnosis of parachordoma was favored. For comparison, an immunohistochemical analysis of five axial chordomas was also performed. The chordomas showed positivity for CK 8/18 (5 of 5 cases), EMA (5 of 5 cases), S100 (5 of 5 cases), CK 1/5/10/14 (1 of 5 cases) and CK7 (1 of 5 cases). Stains for CK20 and CEA were negative in all five chordomas. The results of the present study suggest that the expression of antigens for CK 1/5/10/14, CK7, CK20 and CEA in chordoma might not be as common as what has been previously reported. The results also suggest that parachordoma might not be easily distinguished immunohistochemically from axial chordoma (and therefore also from so-called chordoma periphericum).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Scolyer

Bonar

Palmer³

et al. 2004

Pathology International

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“…Parachordoma is an uncommon soft‐tissue tumor; approximately 40 cases have been reported to date 1–23 . It was first described by Laskowski in 1951 as ‘chordoma periphericum’ considering its histological resemblance to chordoma, with a suggestion that it might be derived from specialized synovial cells 1 .…”

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confidence: 99%

“…However, histogenesis of parachordoma has remained uncertain. Ectopic notochordial remnants (chordoma), lipoblasts, chondroblasts, and many others such as a possible affiliation with synovial tumors including synovial sarcoma, have been claimed 3–6 . More recently, a myoepithelial cell origin has been propounded 24–27 .…”

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Parachordoma or myoepithelion?: A case report of a rare soft tissue tumor

Behzatoğlu

Canberk

Bahadir

et al. 2007

Pathology International

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Parachordoma or chordoma periphericum? Case report of a tumor of the thoracic wall

Tong

Perle

Desai

et al. 2003

Diagnostic Cytopathology

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We report the findings from an aspiration biopsy and resection of a chordoma-like tumorous mass in the wall of the thorax of a 36-yr-old man with immunohistochemical, ultrastructural, and cytogenetic studies. The 4-cm oval tumor was an incidental finding on physical examination, and no other lesions were identified after comprehensive radiologic studies. The aspirate was composed of sheets and nests of cells with distinct borders in a myxoid and fibrillary extracellular matrix. The neoplastic cells were uniform and round or polygonal with abundant pale blue vacuolated cytoplasm and small round, central or eccentric nuclei. On electron microscopy, mitochondrial rough endoplasmic reticulum complexes were seen in neoplastic cells. These features were similar to those of a conventional chordoma. However, the cytogenetic pattern, 43, XY ,-1, -2, der (5)t(1p;5q), -6, add(8p) ,add(10q), was not typical. In addition, the neoplastic cells were positive for vimentin, S-100, AE1/AE3, CAM 5.2, and CK 19; were focally positive for EMA and smooth muscle actin; and were negative for cytokeratin 1 and 10 (34 beta E12), CK 7, CK 8 (35H 11B), CK 17, and CK 20. The cytogenetic and immunohistochemical patterns were different from conventional chordoma and its peripheral counterpart, chordoma periphericum, suggesting the diagnosis of parachordoma. To the best of our knowledge, this is the first report of fine-needle aspiration of this newly defined and rare entity.

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Parachordoma

Cited by 27 publications

References 10 publications

Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Parachordoma is not distinguishable from axial chordoma using immunohistochemistry

Parachordoma or myoepithelion?: A case report of a rare soft tissue tumor

Parachordoma or chordoma periphericum? Case report of a tumor of the thoracic wall

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