Parabens

Background Cosmetics are part of the daily life of the population, and their use can lead to allergic contact dermatitis. Objectives To assess the profile of patients diagnosed with allergic contact dermatitis to cosmetics treated at a referral center for 13 years, as well as the characteristics of the clinical picture and allergens involved. Methods This was a retrospective study, with analysis of medical records of patients attended at this service. The individuals included had a diagnostic hypothesis of allergic contact dermatitis to cosmetics and had previously been submitted to epicutaneous tests. Results A total of 1405 medical records were analyzed, 403 (28.7%) with suspected allergic contact dermatitis to cosmetics and 232 (16.5%) with confirmed diagnosis. Of these, 208 (89.7%) were women, and the age group most affected was 31 − 60 years. The most common locations were face in 195 cases (25.8%), cervical region in 116 (15.3%), and trunk in 96 (12.6%). The main allergens in the contact tests were toluene-sulfonamide-formaldehyde resin in 69 cases (29.7%), paraphenylenediamine in 54 (26.3%), Kathon CG® in 41 (20.7%), and fragrance-mix 1 in 29 (16.4%). In 154 (66.4%) of the 232 patients with a confirmed diagnosis of allergic contact dermatitis to cosmetics it was possible to specify the cosmetic product responsible for the lesions. Study limitations The absence of some allergens considered important in the world as causes of allergic contact dermatitis, which are not readily accessible among us. Conclusions The data of the analyzed population (predominance of young women), as well as the location of the lesions (face and cervical area) and the main allergens involved were consistent with those from the world literature.

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“…The frequency of sensitization ranges from 0.6% to 2.3% in the studies of the North American group. 9 …”

Section: Discussionmentioning

confidence: 99%

Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between 2004 and 2017

Hafner

Rodrigues

Lazzarini

2020

Anais Brasileiros de Dermatologia

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“…6 This includes several cosmetic related allergens that would not need retesting in a separate series, but would need to be considered as changes to the baseline series occur, and as certain allergens are considered for deletion because of the low frequency of allergic reactions. 7 In creating a cosmetic series, the threshold for inclusion could potentially be lower, perhaps from 0.1% to 0.2% among those tested, to minimize the risk of missing a relevant contact allergy. Whilst a T A B L E 1 Allergens tested to diagnose cosmetic allergy in 26 European centres…”

Section: Discussionmentioning

confidence: 99%

“…Allergens within the European baseline series typically produce a frequency of at least 0.5% to 1% allergic reactions in those tested . This includes several cosmetic related allergens that would not need retesting in a separate series, but would need to be considered as changes to the baseline series occur, and as certain allergens are considered for deletion because of the low frequency of allergic reactions …”

Section: Discussionmentioning

confidence: 99%

A survey of members of the European Surveillance System on Contact Allergy and the EU project “StanDerm” to identify allergens tested in cosmetic series across Europe

et al. 2020

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Background: There is currently no agreed cosmetic series for use across Europe.Objectives: To establish allergens currently tested in local and national cosmetic series.Method: Members of the European Surveillance System on Contact Allergy and the European Cooperation in Science and Technology project TD1206 ("StanDerm") were surveyed to establish their current practice.Results: A wide range of allergens was tested but there was significant variation between centres on the allergens considered to be important in screening for allergy to cosmetics.The number of allergens tested in addition to the baseline series varied between 2 and 50.Conclusions: There is a need for further investigation to establish the frequency and relevance of reactions to cosmetic allergens to enable an agreed evidence-based cosmetic series to be produced. Criteria for inclusion need to be established. K E Y W O R D Sallergic contact dermatitis, cosmetic, diagnosis

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“…Parabens are very weak allergens, also considering their use in cosmetics and other products, which was, at least in the past, extensive, with a sensitisation prevalence in consecutively tested patients of around 1% or less [147]. The case of a local anaesthetic-medicated plaster for post-herpetic neuralgia in a 50-year-old patient, who, after 4 months of daily treatment, developed ACD to the plaster, and was found allergic to the parabens included in it, illustrates the so-called paraben paradox: despite ACD to parabens and a positive patch test to these (and a sample of the plaster), the patient tolerated paraben exposure in various cosmetics [148].…”

Section: Preservativesmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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Parabens

Cited by 111 publications

References 188 publications

Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between 2004 and 2017

Allergic contact dermatitis to cosmetics: retrospective analysis of a population subjected to patch tests between 2004 and 2017

A survey of members of the European Surveillance System on Contact Allergy and the EU project “StanDerm” to identify allergens tested in cosmetic series across Europe

Contact Allergy—Emerging Allergens and Public Health Impact

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