Para‐hydrogen induced polarization of Si‐29 NMR resonances as a potentially useful tool for analytical applications

Ellena, Silvano; Viale, Alessandra; Gobetto, Roberto; Aime, Silvio

doi:10.1002/mrc.3832

Cited by 9 publications

(9 citation statements)

References 27 publications

(59 reference statements)

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“…Besides measuring the ratio of lactate to pyruvate, the change in signal can be measured over time and the data fit to kinetic models 136,137,90,138 . Several other metabolites and hyperpolarized nuclei (such as 29 Si, 6 Li, 89 Y) 139,140,141 are currently being tested for use due to their long T 1 relaxation times. Although hyperpolarized NMR based methods have a lot of potential, there are several constraints on its clinical application that need to be overcome.…”

Section: Methods In Metabolic Profiling and Imagingmentioning

confidence: 99%

Recent Advances in Metabolic Profiling and Imaging of Prostate Cancer

Thapar¹,

Titus²

2014

CMB

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Cancer is a metabolic disease. Cancer cells, being highly proliferative, show significant alterations in metabolic pathways such as glycolysis, respiration, the tricarboxylic acid (TCA) cycle, oxidative phosphorylation, lipid metabolism, and amino acid metabolism. Metabolites like peptides, nucleotides, products of glycolysis, the TCA cycle, fatty acids, and steroids can be an important read out of disease when characterized in biological samples such as tissues and body fluids like urine, serum, etc. The cancer metabolome has been studied since the 1960s by analytical techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. Current research is focused on the identification and validation of biomarkers in the cancer metabolome that can stratify high-risk patients and distinguish between benign and advanced metastatic forms of the disease. In this review, we discuss the current state of prostate cancer metabolomics, the biomarkers that show promise in distinguishing indolent from aggressive forms of the disease, the strengths and limitations of the analytical techniques being employed, and future applications of metabolomics in diagnostic imaging and personalized medicine of prostate cancer.

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Section: Methods In Metabolic Profiling and Imagingmentioning

confidence: 99%

Recent Advances in Metabolic Profiling and Imaging of Prostate Cancer

Thapar¹,

Titus²

2014

CMB

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“…T 1 values of more than 1min were determined. [136] 31 Ps ites typically have shorter T 1 times than those of 13 C and 15 Nnuclei, but they have high MR sensitivity because of the significantly higher gyromagnetic ratio of 31 Ps pins than that of 15 N, and feature ac onvenient 100 %n atural abundance.B urns et al examined the hyperpolarization of phosphate,p hosphine,a nd phosphonate derivatives and showed that MR measurement times can be reduced from 12 ht o about 1s . [137] These examples show the wide range of possibilities of MRI probes and applications of PHIP and demonstrate that research is still in progress.…”

Section: Other Phip Contrast Agents Under Developmentmentioning

confidence: 99%

“…examined the 29 Si hyperpolarization of silyl ether derivatives of cortisol, cortisone, extradiol, and estrone. T 1 values of more than 1 min were determined …”

Section: How To Make Use Of Parahydrogen‐induced Polarization: Contramentioning

confidence: 99%

Parahydrogen‐Based Hyperpolarization for Biomedicine

et al. 2018

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Magnetic resonance (MR) is one of the most versatile and useful physical effects used for human imaging, chemical analysis, and the elucidation of molecular structures. However, its full potential is rarely used, because only a small fraction of the nuclear spin ensemble is polarized, that is, aligned with the applied static magnetic field. Hyperpolarization methods seek other means to increase the polarization and thus the MR signal. A unique source of pure spin order is the entangled singlet spin state of dihydrogen, parahydrogen (pH ), which is inherently stable and long-lived. When brought into contact with another molecule, this "spin order on demand" allows the MR signal to be enhanced by several orders of magnitude. Considerable progress has been made in the past decade in the area of pH -based hyperpolarization techniques for biomedical applications. It is the goal of this Review to provide a selective overview of these developments, covering the areas of spin physics, catalysis, instrumentation, preparation of the contrast agents, and applications.

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“…beobachteten erhöhte Signale in Trimethylvinylsilan bereits im Jahr 1996 . Sechzehn Jahre später beobachteten Ellena und Mitarbeiter hyperpolarisiertes 29 Si in Silyletherderivaten von Cortisol, Cortisonextradiol und Estron und fanden T 1 ‐Werte länger als eine Minute …”

Section: Was Kann Man Damit Machen? Die Biomedizinische Anwendungunclassified

Parawasserstoff‐basierte Hyperpolarisierung für die Biomedizin

et al. 2018

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Die Magnetresonanz (MR) von Kernspins ist einer der nützlichsten physikalischen Effekte für die humane Bildgebung, ebenso wie für die Aufklärung von molekularen Strukturen und die chemische Analyse. Das volle Potential der MR kann jedoch kaum genutzt werden, da nur ein geringer Bruchteil aller Kernspins polarisiert, sprich in einem äußeren magnetischen Feld ausgerichtet werden. Hyperpolarisierungsmethoden versuchen, die Polarisierung und damit das MR‐Signal auf anderem Wege zu erhöhen. Eine einzigartige Quelle reiner Spinordnung ist das langlebige, verschränkte Kernspin‐Singulett‐Isomer des Wasserstoffmoleküls, genannt Parawasserstoff (pH2). Mithilfe dieser “Spinordnung auf Abruf” kann das MR‐Signal um mehrere Größenordnungen verstärkt werden, wenn pH2 in Kontakt mit einem anderen Molekül gebracht wird. In Bezug auf eine biomedizinische Anwendung von pH2‐hyperpolarisierten Kontrastmitteln haben in den letzten zehn Jahren beeindruckende Fortschritte stattgefunden. Das Ziel dieses Aufsatzes ist es, diese Entwicklungen in den Bereichen der Spinphysik, Katalyse, Instrumentierung, Kontrastmittel und Anwendungen gebündelt und verständlich darzustellen.

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Para‐hydrogen induced polarization of Si‐29 NMR resonances as a potentially useful tool for analytical applications

Cited by 9 publications

References 27 publications

Recent Advances in Metabolic Profiling and Imaging of Prostate Cancer

Recent Advances in Metabolic Profiling and Imaging of Prostate Cancer

Parahydrogen‐Based Hyperpolarization for Biomedicine

Parawasserstoff‐basierte Hyperpolarisierung für die Biomedizin

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