Para-acyl-calix-arene based solid lipid nanoparticles (SLNs): a detailed study of preparation and stability parameters

Shahgaldian, Patrick; Silva, Éric Da; Coleman, Anthony W.; Rather, Beth; Zaworotko, Michael J.

doi:10.1016/s0378-5173(02)00639-7

Cited by 146 publications

(102 citation statements)

References 29 publications

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“…In this technique, first the lipid(s) is/are dissolved in a water-immiscible organic solvent (e.g., cyclohexane, chloroform) and then emulsified in an aqueous phase containing surfactants under continuous stirring (57,58). The organic solvent evaporates during emulsification, which results in lipid precipitation.…”

Section: Solvent Emulsification-evaporationmentioning

confidence: 99%

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Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

2010

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Abstract. Lipid nanoparticles based on solid matrix have emerged as potential drug carriers to improve gastrointestinal (GI) absorption and oral bioavailability of several drugs, especially lipophilic compounds. These formulations may also be used for sustained drug release. Solid lipid nanoparticle (SLN) and the newer generation lipid nanoparticle, nanostructured lipid carrier (NLC), have been studied for their capability as oral drug carriers. Biodegradable, biocompatible, and physiological lipids are generally used to prepare these nanoparticles. Hence, toxicity problems related with the polymeric nanoparticles can be minimized. Furthermore, stability of the formulations might increase than other liquid nano-carriers due to the solid matrix of these lipid nanoparticles. These nanoparticles can be produced by different formulation techniques. Scaling up of the production process from lab scale to industrial scale can be easily achieved. Reasonably high drug encapsulation efficiency of the nanoparticles was documented. Oral absorption and bioavailability of several drugs were improved after oral administration of the drugloaded SLNs or NLCs. In this review, pros and cons, different formulation and characterization techniques, drug incorporation models, GI absorption and oral bioavailability enhancement mechanisms, stability and storage condition of the formulations, and recent advances in oral delivery of the lipid nanoparticles based on solid matrix will be discussed.

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Section: Solvent Emulsification-evaporationmentioning

confidence: 99%

“…Particle size less than 300 nm are advisable for the intestinal transport (62). Photon correlation spectroscopy (PCS; 28,31,38,58,63,64) and laser diffraction (LD; 33,43,63) are the most powerful and widely used techniques for the particle size measurement of lipid nanoparticles. PCS is also known as dynamic light scattering.…”

Section: Particle Sizementioning

confidence: 99%

Recent Advances in Lipid Nanoparticle Formulations with Solid Matrix for Oral Drug Delivery

2010

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“…21 It was reported that smaller particle sizes were obtained by increasing the solvent to oil ratio, which was also observed for the calixpyrrole solid lipid nanoparticles. Structurally related C-undecyl resorcinarene 15 and para-dodecanoyl calixarene 13 showed a similar trend in solvent to amphiphile ratio.…”

Section: Discussionmentioning

confidence: 82%

“…Therefore, a solvent system which would not dissolve plastic cuvettes was required. Among the water-miscible solvents typically used for SLN preparation (acetone, ethanol, methanol and THF 13 ), ethanol is a benign solvent, which dissolves the investigated calixpyrroles well, and was therefore chosen for the particle studies.…”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

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Solid lipid nanoparticles from amphiphilic calixpyrroles

Helttunen

Galán

Ballester

et al. 2016

Journal of Colloid and Interface Science

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HypothesisMacrocyclic amphiphiles form interesting self-assembling structures, including solid lipid nanoparticles, which have potential applications in drug encapsulation. Aryl-extended calixpyrroles, which act as anion binding hosts, are expected to form solid lipid nanoparticles, even though the alkyl chains have unusual perpendicular geometry with respect to the hydrophilic head group. The preparation conditions and the alkyl chain length should affect the size and stability of the particles. ExperimentsSolid lipid nanoparticles of two aryl-extended calixpyrroles with resorcinol walls and either meso-dodecyl or meso-methyl alkyl chains were compared. Ethanolic solutions of the calixpyrroles were mixed with water and the resulting nanoparticle dispersions were studied with dynamic light scattering and nanoparticle tracking analysis. The effect of different calixpyrrole/ethanol/water ratios on particle size was tested. The surface charge of the particles at different pH and NaCl concentration was determined by zeta potential measurements. 2 FindingsThe meso-dodecyl calixpyrrole produced small nanoparticles with mean hydrodynamic diameters between 40-70 nm in 0.86-4.28 M ethanol. The particles were stable in solution for several months. Particles prepared from meso-methyl calixpyrrole were larger and less stable.The smallest particles were obtained with low calixpyrrole concentration and calixpyrrole/ethanol ratio. Larger ethanol/water ratio induced broader particle size distributions. Increasing pH aided the stability of the particles due to increased negative surface charge.

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