Par j 1 and Par j 2, the major allergens from <i>Parietaria judaica</i> pollen, have similar immunoglobulin E epitopes

Asturias, Juan A.; Gómez-Bayón, N; Eseverri, J L; Martı́nez, Alberto

doi:10.1046/j.1365-2222.2003.01631.x

Cited by 41 publications

(43 citation statements)

References 38 publications

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“…It is interesting to point out that this labelling was less intense than that obtained with Pla a 1 and Pla a 2, the major allergens of P. acerifolia pollen grains (Suárez-Cervera et al, 2005). Regarding P. judaica pollen grains, their major allergens, Par j 1 and Par j 2, represent another type of nsLTP member (Ayuso et al, 1995;Costa et al, 1994;Asturias et al, 2003). Although the sequential positions for IgE epitopes of Par j 1 and Par j 2 and Pru p 3 show similarities of 26-29%, both allergens have strong sequence divergence in most of their regions (Salcedo et al, 2004(Salcedo et al, , 2007.…”

Section: Pollen Vs Nsltp Diversitymentioning

confidence: 78%

“…Recently published reviews have provided a thorough background on nsLTPs in foods and pollen (Mills et al, 2004;Salcedo et al, 2004Salcedo et al, , 2007Breiteneder & Mills, 2005). Major allergens of Parietaria judaica L. pollen grains, Par j 1 and Par 2, belong to the nsLTP family (Costa et al, 1994;Asturias et al, 2003; (1). Fumariaceae, Fumaria capreolata (18.5 mm); (2).…”

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confidence: 99%

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An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains

Suárez‐Cervera

Vega-Maray

Castells

et al. 2008

Grana

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Section: Pollen Vs Nsltp Diversitymentioning

confidence: 78%

mentioning

confidence: 99%

An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains

Suárez‐Cervera

Vega-Maray

Castells

et al. 2008

Grana

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“…With respect to wall pellitory allergy, Par j 1 and Par j 2 have been described as major allergens in P. judaica pollen [47,48]. Although they both belong to the largely cross-reactive LTP allergen group, they in fact lack significant cross-reactivity to other pollen or plant-food LTPs, thus conferring specificity of induced IgE for the Parietaria genus [49,50,51].…”

Section: Markers Of Genuine Sensitization To Major Pollen Sourcesmentioning

confidence: 99%

A Molecular Diagnostic Algorithm to Guide Pollen Immunotherapy in Southern Europe: Towards Component-Resolved Management of Allergic Diseases

Douladiris

Savvatianos

Roumpedaki

et al. 2013

Int Arch Allergy Immunol

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Correct identification of the culprit allergen is an essential part of diagnosis and treatment in immunoglobulin E (IgE)-mediated allergic diseases. In recent years, molecular biology has made important advances facilitating such identification and overcoming some of the drawbacks of natural allergen extracts, which consist of mixtures of various proteins that may be allergenic or not, specific for the allergen source or widely distributed (panallergens). New technologies offer the opportunity for a more accurate component-resolved diagnosis, of benefit especially to polysensitized allergic patients. The basic elements of molecular diagnostics with potential relevance to immunotherapy prescription are reviewed here, with a focus on Southern European sensitization patterns to pollen allergens. We propose a basic algorithm regarding component-resolved diagnostic work-up for pollen allergen-specific immunotherapy candidates in Southern Europe; this and similar algorithms can form the basis of improved patient management, conceptually a ‘Component-Resolved Allergy Management'.

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“…Both belong to the nonspecific lipid transfer protein (LTP) family, and there is extended IgE cross-reactivity between the two allergens, but not between Par j 1/2 and other plant LTPs [5,6]. The most important allergen in ragweed pollen is Amb a 1, a pectate lyase that is recognized by IgE antibodies in more than 95% of ragweed-allergic patients [7,8].…”

Section: Introductionmentioning

confidence: 99%

Mugwort-Sensitized Individuals from North Europe, South Europe and North America Show Different IgE Reactivity Patterns

Movérare¹,

Larsson²,

Carlsson³

et al. 2010

Int Arch Allergy Immunol

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Background: Sensitization to weed pollen allergens at the molecular level is not fully understood. We studied IgE reactivity to the major mugwort allergen Art v 1 in relation to allergens from other weed pollen and cross-reactive components in mugwort-sensitized subjects. Methods: Art v 1 and Amb a 1 were affinity purified and coupled to experimental ImmunoCAP® tests. Samples from North Europe (n = 50), South Europe (n = 19) and North America (n = 41) were analyzed for IgE against mugwort pollen, weed allergen components, pan-allergens and cross-reactive carbohydrate determinants (CCDs). Results: The prevalence of IgE reactivity (>0.35 kU_A/l) to Art v 1 was significantly higher in samples from North Europe than in those from North America. IgE to Amb a 1 was more common in North America than in North and South Europe, while IgE to Par j 2 was common in South Europe, less common in North America, and absent in North Europe. IgE to Art v 3 in mugwort-allergic patients was more common in North Europe than in South Europe and North America, while IgE to Sal k 1 was similar between the areas. Subjects with an Art v 1/mugwort-specific IgE ratio <0.5 had more often IgE to Amb a 1, profilin, polcalcin and CCDs than subjects with a ratio >0.5. Conclusions: Mugwort-sensitized subjects have different IgE reactivity profiles to weed allergens, reflecting their exposure to various pollens. Subjects with a low ratio between the IgE levels to Art v 1 and mugwort have a diverse IgE reactivity profile, indicating a role for cross-reactive allergens in their mugwort sensitization.

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Par j 1 and Par j 2, the major allergens from Parietaria judaica pollen, have similar immunoglobulin E epitopes

Abstract: Three similar IgE-epitopes of major allergens from P. judaica have been described. They could be good candidates for designing of IgE haptens as therapeutic agents with reduced anaphylactic side-effects or for developing hypoallergenic variants of these major allergens.

Cited by 41 publications

References 38 publications

An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains

An approach to the knowledge of pollen and allergen diversity through lipid transfer protein localisation in taxonomically distant pollen grains

A Molecular Diagnostic Algorithm to Guide Pollen Immunotherapy in Southern Europe: Towards Component-Resolved Management of Allergic Diseases

Mugwort-Sensitized Individuals from North Europe, South Europe and North America Show Different IgE Reactivity Patterns

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