Papular‐purpuric Gloves‐and‐socks Syndrome

Abstract

The PPGSS represents a distinctive dermatosis and a manifestation of HPV B19 infection. Unlike erythema infectiosum, anti-HPV B19 antibodies seem to develop later after onset of the skin eruption and while viremia is still present.

Papular-purpuric "gloves and socks" syndrome due to parvovirus B19: report of a case with unusual features

“…Initially, edema and erythema appear on the hands and feet in a "gloves and socks" distribution, followed by isolated or confluent erythematopapular and purpuric lesions on the same sites, frequently accompanied by pruritus and pain. In some cases, similar lesions may also be observed on other sites, including face, trunk, buttocks, groin, elbows, knees, and thighs 21 . Systemic symptoms, such as asthenia, headache, anorexia, and arthralgia usually accompany skin eruptions.…”

“…Purpura associated with skin necrosis and superficial ulcerations was reported in a case of arthritis and vasculitis due to B19 infection 13 . Although some PPGSS patients develop desquamation of the involved areas as the syndrome resolves 21 , healing with thick black eschars has not to our knowledge been previously described in this syndrome.…”

“…However, it is not known whether the rash is a manifestation of primary viremia or a consequence of immune complex formation 19 . In several B19-related PPGSS cases, B19-specific IgM antibody has not been demonstrated in serum at the time of the initial presentation with rash and pruritus, suggesting that the mucocutaneous lesions develop during the period of viremia 2,19,21 . In the present case, both B19-specific IgG and IgM were detected in serum collected on the seventh day of illness, which might suggest that the rash occurred when an antibody response had already developed.…”

Papulopurpurisches Gloves-and-socks-Syndrom

“…Meist findet sich ein perivaskulä-res vorwiegend lymphozytäres Infiltrat ohne Vaskulitis mit Erythrozytenextravasaten in der papillären Dermis. Daneben besteht eine leichte Akanthose, fokale Parakeratose und stellenweise eine hydropische Degeneration der Basalzellschicht [4,9,22,32,33,44,45].…”

Papular-Purpuric ‘Gloves-and-Socks’ Syndrome Related to Rubella Virus Infection

“…This clinical entity was reported by Harms et al [1]in 1990. Parvovirus B19 has been the virus most often implicated [2, 3], although other viruses like coxsackievirus B6 [4], cytomegalovirus [5], measles virus [6], Epstein-Barr virus [7]and human herpesvirus 6 [8]were also detected.…”