Papular pseudolymphoma of adults as a variant of acral pseudolymphomatous angiokeratoma of children (APACHE)

Wagner, Gunnar; Rosé, Christian; Sachse, Michael Max

doi:10.1111/ddg.12291

Cited by 5 publications

(6 citation statements)

References 10 publications

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“…Acral pseudolymphomatous angiokeratoma (APA) was originally described in children (synonym: acral pseudolymphomatous angiokeratoma of childhood, or APACHE), but it can also affect adults and its localization is not exclusively acral . APA manifests clinically as unilateral eruptions of red to violaceous, angiomatous, grouped papules (diameter 1 to 5 mm).…”

Section: Classification Of Pseudolymphomamentioning

confidence: 99%

Cutaneous pseudolymphoma—A review on the spectrum and a proposal for a new classification

2019

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Cutaneous pseudolymphomas (PSLs) belong to a group of lymphocytic infiltrates that histopathologically and/or clinically simulate lymphomas. Different causative agents (e.g., Borrelia sp., injected substances, tattoo, arthropod bite) have been described, but in many cases no cause can be identified, hence the term idiopathic PSL. Clinicopathological correlation is important to make the diagnosis. Four main groups of cutaneous PSL can be distinguished based on histopathologic and/or clinical presentation: (a) nodular PSL; (b) pseudo-mycosis fungoides (pseudo-MF) and simulators of other CTCLs; (c) other PSL (representing distinct clinical entities); and (d) intravascular PSL. This article gives an overview of the histopathologic and clinical characteristics of cutaneous PSLs and proposes a new classification.

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Section: Classification Of Pseudolymphomamentioning

confidence: 99%

Cutaneous pseudolymphoma—A review on the spectrum and a proposal for a new classification

2019

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“…Esto difiere de los seudolinfomas, que suelen localizarse con mayor frecuencia en la cara y el cuello [6] . Aunque su nombre implica una localización distal, cabe resaltar que los pacientes 9 y 10 presentaron lesiones solitarias en el tronco [16][17][18][19][20][21][22][23][24] ; en el paciente 7, se F: femenino; M: masculino; L: linfocitos; H: histiocitos; E: eosinófilos; PC: células plasmáticas; MNGC: células gigantes multinucleadas; BCL: capa de células basales; VS: vasos sanguíneos; IL: intralesional; ND: no disponible; j: cadena kappa; k: cadena lambda; PCR: reacción en cadena de la polimerasa Tabla 1. Revisión de casos publicados en la bibliografía internacional con el diagnóstico de enfermedad de APACHE (niños y adultos) acompañó de alteraciones de la lámina ungular pues las lesiones se extendían hasta el pliegue ungular proximal [4] .…”

Section: Discussionunclassified

Angioqueratoma distal seudolinfomatoso infantil:

Saponaro,

Marini,

Parra

et al. 2018

rev. asoc. colomb. dermatol. cir. dematol.

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El acróstico APACHE (Acral Pseudolymphomatous Angiokeratoma of Children) corresponde a una variante de los seudolinfomas cutáneos. El término fue introducido por Ramsay, et al., en 1988, cuando publicaron cinco casos de pacientes pediátricos con múltiples pápulas angiomatosas, unilaterales, que se localizaban en la región distal de las extremidades. En el estudio histopatológico se observaba un infiltrado dérmico linfohistiocitario nodular con capilares prominentes.En la actualidad, los nombres de “seudolinfoma de pequeñas pápulas” o “hiperplasia angiolinfoide papulosa” serían los más convenientes, ya que no siempre se presenta en niños, es de localización distal o se observan cambios angiomatososen el estudio de histopatología.Se presenta el caso de una niña con una lesión distal en el segundo dedo del pie izquierdo, cuyo diagnóstico de angioqueratoma distal seudolinfomatoso infantil se hizo mediante el estudio histopatológico. Además, se hacen comentarios sobreesta rara entidad.

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“…Finally, there are at least nine reports of APACHE arising in adults [2,5,7,9,[12][13][14]16], suggesting that this disease is not confined to children.…”

Section: Discussionmentioning

confidence: 99%

“…Studies have consistently shown a mixture of T and B cells [1,[4][5][6][7][8][9][10][11][12][13][14][15][16], with the former usually being the dominant cell type. This would comprise near equal numbers of CD4+ and CD8+ cells.…”

Section: Discussionmentioning

confidence: 99%

Papular angiolymphoid hyperplasia and lymphoplasmacytic plaque: a clinical and histological spectrum

Yeo

Oon²,

Lee³

et al. 2016

Dermatology Online Journal

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Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare form of cutaneous pseudolymphoma characterized by angiomatous papules with a predilection for the acral regions of children. Classically, a dense dermal lymphocytic infiltrate composed of both T and B cells is seen in histological specimens, together with prominent vessels lined by plump endothelial cells. Increasing evidence suggests that this condition is neither necessarily acral, pseudolymphomatous, nor angiokeratomatous. It may not always be a pediatric disease. Therefore, the correctness of its nomenclature has been questioned. Herein, we report three cases whose clinical and histological features were consistent with the diagnosis of APACHE. To our knowledge, this is the first report of APACHE from Southeast Asia. We also discuss why we believe "APACHE" to be a misnomer and support "papular angiolymphoid hyperplasia" as a more accurate and encompassing term. In addition, we illustrate a case with significant overlapping features with lymphoplasmacytic plaque in children, suggesting that both entities may exist on a clinical and histological spectrum.

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Papular pseudolymphoma of adults as a variant of acral pseudolymphomatous angiokeratoma of children (APACHE)

Cited by 5 publications

References 10 publications

Cutaneous pseudolymphoma—A review on the spectrum and a proposal for a new classification

Cutaneous pseudolymphoma—A review on the spectrum and a proposal for a new classification

Angioqueratoma distal seudolinfomatoso infantil:

Papular angiolymphoid hyperplasia and lymphoplasmacytic plaque: a clinical and histological spectrum

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