Papulacandins, a new family of antibiotics with antifungal activity. I. Fermentation, isolation, chemical and biological characterization of papulacandins A, B, C, D and E.

Traxler, Peter; Gruner, J.; Auden, J. A. L.

doi:10.7164/antibiotics.30.289

Cited by 139 publications

(57 citation statements)

References 10 publications

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“…In an important observation, the lysis of aculeacin A-treated S. cerevisiae appeared to be largely restricted to the growing tips of budding cells, likely a reflection of the incomplete cross-linking of wall components during the dynamic process of bud growth (167). Supporting this conclusion, the fungicidal activities of papulacandin B and echinocandin B were found to be restricted to actively growing yeasts; resting cells were unaffected (47,248).…”

Section: Inhibitors Of Glucan Synthesissupporting

confidence: 63%

“…Similar to the effects noted for the chitin synthetase inhibitors, treatment of intact yeasts with echinocandin and papulacandins appeared to cause the formation of osmotically sensitive cells (47,248). Papulacandin B treatment also caused cells to grow in forms resembling pseudohyphae.…”

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 62%

“…Although the papulacandins are highly active against Candida spp. at levels equal or superior to those of azole and polyene antifungal agents, these compounds are inactive against Cryptococcus neofonnans and several filamentous fungi (248). Similarly, aculeacins A to D and F to G have good in vitro activity against Candida spp.…”

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 92%

“…The papulacandins, first described in 1977, are a complex of five compounds, i.e., papulacandins A, B, C, D, and E, isolated from a strain of Papulania sphaerospenna (98,248). These amphophilic compounds have a unique structure, described as a spirocyclic diglycoside esterified by two long-chain unsaturated fatty acids (Fig.…”

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 99%

“…The papulacandins have been evaluated in a mouse model of systemic candidiasis and found to have good activity, with 50% effective doses of 180 and 80 mg/kg for papulacandin A and B, respectively (248).…”

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 99%

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Compounds active against cell walls of medically important fungi

Hector

1993

Clin Microbiol Rev

215

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A number of substances that directly or indirectly affect the cell walls of fungi have been identified. Those that actively interfere with the synthesis or degradation of polysaccharide components share the property of being produced by soil microbes as secondary metabolites. Compounds specifically interfering with chitin or beta-glucan synthesis have proven effective in studies of preclinical models of mycoses, though they appear to have a restricted spectrum of coverage. Semisynthetic derivatives of some of the natural products have offered improvements in activity, toxicology, or pharmacokinetic behavior. Compounds which act on the cell wall indirectly or by a secondary mechanism of action, such as the azoles, act against diverse fungi but are usually fungistatic in nature. Overall, these compounds are attractive candidates for further development.

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Section: Inhibitors Of Glucan Synthesissupporting

confidence: 63%

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 62%

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 92%

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 99%

Section: Inhibitors Of Glucan Synthesismentioning

confidence: 99%

See 3 more Smart Citations