“…However, to date only a limited number of genes are validated to be regulated by E2. These include MMP-9 (Behren et al, 2005), hTERT (Lee et al, 2002), SF2/ASF (Klymenko et al, 2016; Mole et al, 2009), IL-10 (Bermudez-Morales et al, 2011), p21 (Steger et al, 2002), involucrin (Hadaschik et al, 2003), β 4-integrin (Oldak et al, 2010) and most recently c-Fos (Delcuratolo et al, 2016). Brd4 is necessary for E2’s function as a transcriptional activator when E2BS is positioned away from the promoter-proximal region in an enhancer-like sequence context (Lee and Chiang, 2009) as found in CRPV (see Fig.…”