Papillomas and carcinomas of the choroid plexus in children

Pencalet, Philippe; Sainte‐Rose, Christian; Lellouch‐Tubiana, Arielle; Kalifa, Chantal; Brunelle, Françis; Sgouros, Spiros; Meyer, Philippe; Cinalli, Giuseppe; Zérah, Michel; Pierre-Kahn, Alain; Rénier, Dominique

doi:10.3171/jns.1998.88.3.0521

Cited by 197 publications

(96 citation statements)

References 49 publications

(70 reference statements)

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“…As a result, we recommend limiting the resection to avoid neurologic injury. Overall, the incidence of complications observed in our study compares favorably with other published studies [5,7,9,11], particularly those including patients treated in the pre-microsurgical era [6,12,13], in which perioperative mortality was high, especially in children [14][15][16][17][18][19]. Compared to published series from the modern microsurgical era, our observed morbidity and mortality were very minimal, once again confirming that these tumors can be safely resected in both children and adults [2,3,5,9,11].…”

Section: Discussionsupporting

confidence: 66%

Surgical outcomes in choroid plexus papillomas: an institutional experience

et al. 2013

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Choroid plexus papillomas (CPPs) are rare, indolent lesions that comprise less than 0.5 % of intracranial tumors. We sought to assess the long-term outcomes and associated surgical complications at our institution. A review of the University of California, San Francisco (UCSF) Brain Tumor Research Center (BTRC) database was performed to identify a cohort of patients treated for CPP from 1997 to 2011. Patients were grouped based on tumor location and extent of resection. Outcomes including progression-free survival and surgical complications were assessed. We identified 24 patients (16 female, 8 male) ranging in age from 6 months to 55 years (median 29 years) treated at our institution. Tumors were found in the following locations: 16 (67 %) fourth ventricle/cerebellopontine angle; 7 (29 %) lateral ventricle; 1 (4 %) third ventricle. Gross total resection (GTR) was achieved in 20 patients (83 %) with subtotal resection (STR) in 4 (17 %). Median follow-up time was 2.8 years with 3 recurrences identified at 1.6, 3.3, and 8.5 years. Extent of resection and tumor location were not associated with recurrence. There was one new permanent neurologic deficit detected after surgery. All patients were alive at most recent follow-up. Attempted gross total resection is the standard treatment for CPPs and generally associated with excellent outcomes. Since recurrences are rare, even among patients who undergo STR, radiation may be reserved for cases of tumor progression. This modern experience at a tertiary care center performed exclusively during the MRI-era demonstrates that CPPs can be safely removed with minimal morbidity and good tumor control.

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Section: Discussionsupporting

confidence: 66%

Surgical outcomes in choroid plexus papillomas: an institutional experience

et al. 2013

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“…Choroid plexus papillomas and carcinomas are rare neoplasms which account for less than 1% of all brain tumours; they are mainly located in the lateral and in the fourth ventricle [1,2,3]. …”

Section: Introductionmentioning

confidence: 99%

Aquaporin(s) Expression in Choroid Plexus Tumours

Longatti¹,

Basaldella²,

Orvieto

et al. 2006

Pediatr Neurosurg

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Objective: It was the aim of this study to investigate the pattern of aquaporin 1 (AQP1) expression in normal and neoplastic choroid plexus, with specific reference to the association with communicating hydrocephalus or liquoral cysts. Second, to infer a new view on the cerebrospinal fluid plexus production and on the etiology of the cysts and communicating hydrocephalus occasionally associated with choroid plexus papillomas. Materials and Methods: Nineteen paraffin-embedded specimens, 10 of normal choroid plexus and 9 of choroid plexus tumours, were immunostained with a monoclonal antibody raised against the intracellular C-terminal AQP1 epitope. Results were analysed in terms of intensity and intracellular distribution of immunostaining and in terms of number of stained cells; they were considered in light of the clinical association with hydrocephalus or liquoral cysts. Results: AQP1 was heavily expressed in the apical side of the choroid epithelium in normal plexus specimens. Choroid plexus papillomas showed a very heterogeneous pattern of AQP1 expression. Immunostaining was absent in the case of choroid plexus carcinoma. Very strong to strong and diffuse AQP1 expression in large to very large papillomas was associated with liquoral cysts or communicating hydrocephalus. Conclusions: AQP1 expression characterizes normal choroid plexus and plexus papillomas. Intensity and diffusion of AQP1 expression together with the size of the tumour mass are somewhat predictive of communicating hydrocephalus or liquoral cyst, lesions possibly caused by a disturbance of cerebrospinal fluid homeostasis.

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“…Nevertheless, the infant’s brain is able to compensate impairment of functional areas, often without persistent deficits [17, 18,] and subtotal extirpation, with the risk of malignant transformation, has a considerably poorer prognosis than total extirpation [1, 7, 8, 11, 14, 15]. Thus, in our opinion total extirpation should be the goal for treatment of infantile plexus papilloma, even if adjacent to functionally important areas.…”

Section: Discussionmentioning

confidence: 99%

“…It is widely agreed that in plexus papilloma, total extirpation should be the aim of surgery [1, 7, 8, 11, 14]. Moreover, total extirpation should be the goal in both ‘elective interventions’ and emergency surgery.…”

Section: Discussionmentioning

confidence: 99%

“…Early signs are usually the result of increased intracranial pressure. In the case of unspecific early symptoms [8,11,12,13,14,15], infants may first present to the neurosurgeon at the stage of imminent herniation. Due to the acute symptoms and the often extensive tumor vascularization [5, 14], the choice of the surgical procedure may be difficult in this emergency situation.…”

Section: Introductionmentioning

confidence: 99%

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Infant with Unusually Large Choroid Plexus Papilloma Undergoing Emergency Surgery

Picht¹,

Jansons²,

Baalen³

et al. 2006

Pediatr Neurosurg

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Choroid plexus papillomas are one of the most common tumors of the nervous system in infants. The most frequent early symptoms, megalocephalia and vomiting, caused by elevated intracranial pressure often lead to a diagnosis only at a critical clinical stage. This study describes a case of a 3-month-old infant with a choroid plexus papilloma measuring 7 × 8 × 6 cm originating in the right lateral ventricle. The infant underwent emergency surgery in an acutely deteriorated state, i.e., acute herniation symptoms with fixed and dilated pupils. Despite of the size of the tumor, the proximity to eloquent cortex, and clinically deteriorated state, the infant recovered completely.

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Papillomas and carcinomas of the choroid plexus in children

Cited by 197 publications

References 49 publications

Surgical outcomes in choroid plexus papillomas: an institutional experience

Surgical outcomes in choroid plexus papillomas: an institutional experience

Aquaporin(s) Expression in Choroid Plexus Tumours

Infant with Unusually Large Choroid Plexus Papilloma Undergoing Emergency Surgery

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