Papillomas

Interferons and tumor necrosis factors have similar catabolic effects on 3T3 L1 cells.

“…Although there is considerable structural and functional heterogeneity among these families of cytokines, they all appear to have roles in the regulation of host immunity and inflammation (7-12). When administered parenterally at high doses they can be toxic, and many of the symptoms associated with the common cold and influenza such as fever, nausea, and muscle aches can be induced by the administration of pure cytokines (13,14). Unraveling the sequence of cytokine actions that occur during the host response to infection is very complex because (i) cytokines regulate the production of one another (15-17), (ii) an individual cell may produce many different cytokines (18, 19), and (iii) different cytokines may have similar bioactivities, as is the case with TNF-a, IL-1, and IFN-a, all of which appear to have direct antiproliferation activities in vitro (20,21).…”

Systemic Treatment of Condylomata Acuminata with Recombinant Interferon-Alpha-2A: Low-Dose Superior to the High-Dose Regimen

“…An efficient and safe treatment of geni tal warts has become of special impor tance because of the following points: the complications and the high relapse rate seen after conventional therapy (surgery or local chemicals) [1]; the worldwide in crease of such lesions induced by human papillomaviruses (HPV) during the last 10 years [2], and the possible link between certain sexually transmissible strains of HPV, responsible for genital warts, and invasive cancer and precursors of the cer vix uteri, the vulva and the penis [3,4], In several mostly uncontrolled clinical trials the efficacy of interferon (IFN)-alpha given topically, intralesionally or parenterally has been well document ed [5][6][7][8][9][10] in the treatment of patients with condylomata acuminata and plana. In these studies preparations of human leukocyte IFN from various sources have been used.…”