Papillary Urothelial Neoplasms: Clinical, Histologic, and Prognostic Features

Abstract

Primary bladder neoplasms can be divided into two broad categories: flat and papillary lesions. In this chapter, we provide a review of non-invasive papillary urothelial neoplasms of the bladder: urothelial papilloma, inverted urothelial papilloma, papillary urothelial neoplasm of low malignant potential (PUNLMP), non-invasive low grade papillary urothelial carcinoma, and noninvasive high grade papillary urothelial carcinoma. The following is discussed for each entity: clinical features, etiology, microscopic description, ancillary tests, molecular alterations, and prognostic factors.

Low-grade papillary urothelial neoplasm: A case report study

“…Histopathologically, low-grade papillary urothelial neoplasm is defined as a papillary configuration of the urothelium with a fibrovascular core. Prominent nucleoli and brisk upper-level mitosis are present, but there is no invasion through the basement membrane [11] .…”