Papillary tumour of the pineal region

Poulgrain, Katherine; Gurgo, Ross; Winter, Chris; Ong, Benjamin; Lau, Queenie

doi:10.1016/j.jocn.2010.12.027

Cited by 33 publications

(33 citation statements)

References 32 publications

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“…Clinical implication of these findings has not yet been elucidated. [5,11]. Among these patients, 10 were children under 16 years of age (Table 1) [5][6][7]12,13].…”

Section: Histological Diagnosismentioning

confidence: 99%

“…[5,11]. Among these patients, 10 were children under 16 years of age (Table 1) [5][6][7]12,13]. Clinical manifestations include headache, diplopia, dizziness and vomiting [5,[12][13][14].…”

Section: Histological Diagnosismentioning

confidence: 99%

“…Four out of 6 pediatric patients suffered from local tumor recurrence, the others were lost to follow-up [6,12,13]. Poulgrin et al investigated the 5-year and 10-year progression free survival of all reported cases to date, which has been estimated at 34.5% and 8.6%, respectively [5]. Fèvre-Montange et al performed univariate analysis to test the prognostic significance of clinical variables such as age, gender, tumor size, gross total tumor resection and adjuvant radiotherapy [6].…”

Section: Histological Diagnosismentioning

confidence: 99%

“…First described by Jouvet et al in 2003 [3], PTPR have been included in the 2007 World Health Organization Classification of Tumors of the Nervous System as a separate tumor entity [4]. Among 70 PTPR reported to date, examples are recognized in both children and adults with ages ranging from 5-67 years (mean, 34 years) [5]. PTPR has a distinctive epithelial character and shows both solid and papillary architecture [3,5,6].…”

Section: Introductionmentioning

confidence: 99%

“…Among 70 PTPR reported to date, examples are recognized in both children and adults with ages ranging from 5-67 years (mean, 34 years) [5]. PTPR has a distinctive epithelial character and shows both solid and papillary architecture [3,5,6]. Immunohistochemical analysis is crucial to distinguish PTPR from morphological similar pineal tumors, mainly papillary ependymoma and choroid plexus papilloma [7].…”

Section: Introductionmentioning

confidence: 99%

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Pediatric papillary tumors of the pineal region: to observe or to treat following gross total resection?

et al. 2012

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We present the case of a 3-year-old girl diagnosed with PTPR. Due to her young age, adjuvant radiotherapy was omitted after gross total tumor resection. Thirty-six months later, local tumor recurrence occurred. Considering the possible risks of secondary surgery, the recurrent tumor was irradiated with proton radiotherapy. Three months later, the tumor showed near-complete remission. DISCUS-SION: Based on this experience and other pediatric case reports from the literature, local radiotherapy might be suggested also after complete tumor resection. Originally published at: Abela, Lucia; Rushing, Elisabeth Jane; Ares, Carmen; Scheer, Ianina; Bozinov, Oliver; Boltshauser, Eugen; Grotzer, Michael A (2013). Pediatric papillary tumors of the pineal region: to observe or to treat following gross total resection? Child's Nervous System, 29 (2) Based on this experience and other pediatric case reports from the literature, local radiotherapy might be suggested also after complete tumor resection.

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“…Clinical implication of these findings has not yet been elucidated. [5,11]. Among these patients, 10 were children under 16 years of age (Table 1) [5][6][7]12,13].…”

Section: Histological Diagnosismentioning

confidence: 99%

“…[5,11]. Among these patients, 10 were children under 16 years of age (Table 1) [5][6][7]12,13]. Clinical manifestations include headache, diplopia, dizziness and vomiting [5,[12][13][14].…”

Section: Histological Diagnosismentioning

confidence: 99%

Section: Histological Diagnosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Pediatric papillary tumors of the pineal region: to observe or to treat following gross total resection?

et al. 2012

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Management of Pineal Region Tumors

Choque-Velasquez

Andrade-Barazarte

Zemmar

et al. 2020

Principles of Neuro-Oncology

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Results of the treatment of pineal tumors in children: the Lyon experience

Szathmari

Beuriat²,

Vasiljevic³

et al. 2022

Childs Nerv Syst

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Pineal tumors are rare and their incidence is of 1% among all pediatric tumors of the central nervous system. The survival depends on the histology, the extension of the surgical removal, the e cacy of the complementary treatment (chemotherapy and cranio-spinal irradiation) in relation with the age of the children.We report our experience in Lyon concerning 151 patients treated from 1997 to 2021. All patients were recorded in the French Register of Pineal tumors which is centralized in Lyon since 2010.The analysis shows that benign tumors have a good survival rate and a total surgical removal is manadatory. Concerning true pineal tumors, pinealoblastomas have a bad prognostic especially in children aged inferior to three years old. The new pathological classi cation allows a better strati cation with different groups identi ed and also the identi cation of a DICER 1 syndrome in family of patients with a pinealoblastoma that need medical investigations. Results of Germ Cell Tumors are more favorable with a global survival rate of 87 % and a rate of survival for pure germinomas of almost 97%.Results for gliomas of the pineal gland, that are tectal plate gliomas, are good for pilocytic astrocytomas while for other gliomas the prognosis is related to the grade of malignancy and the e cacy of complementary treatment. Papillary tumors need a complete removal for the best chance of survival.Finally, AT/TR still have a bad prognosis.Our results show that many progresses have to be accomplished for pineal region tumors and that these pathologies need a multidisciplinary approach to choose the best treatment to improve the survival rate and the patients' quality of life.Out 891 tumors 316 patients (33%) are children: 165 of the 316 patients (54%) have been treated in different French centers and 151(46%) have been treated in Lyon and are considered for this report.Results of the French register were already published in a previous paper. [6] Materials And Methods All pediatric patients that have been treated from January 1997 to December 2020 in Lyon in the Department of Pediatric Neurosurgery have been considered. All these patients are recorded in the French Register of Pineal Tumors. 151 patients were eligible for the study with an age between one years to eighteen years old. The sex ratio was of 1.2 males /Girl.The symptomatology was characterized in 54% by signs of intracranial hypertension with headaches and vomiting. Ophthalmological troubles were present in 21% of patients, endocrinological problems were associated in 5% of cases, while in others 18% of patients the clinical manifestations were characterized by more insidious manifestations as asthenia, tiredness and gradual lowering of scholar performances.All patients were studied with a cerebro-spinal MRI with and without Gadolinium with angio-MRI sequences to study arterial feeders and the venous structures. The CT-scan was realized in some patients performed in peripheral hospitals. We never realized angiography by the Seldinger technique for the surgical p...

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Papillary tumour of the pineal region

Cited by 33 publications

References 32 publications

Pediatric papillary tumors of the pineal region: to observe or to treat following gross total resection?

Pediatric papillary tumors of the pineal region: to observe or to treat following gross total resection?

Management of Pineal Region Tumors

Results of the treatment of pineal tumors in children: the Lyon experience

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