Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution

Pan, Jun; Ye, Fang; Yu, Chengxuan; Zhu, Qinsheng; Li, Jiaqi; Tian, Hedi; Yao, Yunjin; Zhu, Man; Shen, Yi-Bin; Zhu, Feng; Wang, Yingying; Zhou, Xinhui; Guo, Guoji; Wu, Yijun

doi:10.3389/fcell.2021.758339

Cited by 26 publications

(35 citation statements)

References 68 publications

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“…The increase in thyroidal B cells associated with pre-existing thyroiditis could therefore also be an important event contributing to immune-mediated control of PTC. Moreover, the emerging role of tumor-infiltrated B cells, using human samples, showed an enrichment pattern of these subsets only in PTC tissues concurrent with thyroiditis but not in the PTC alone, suggesting a promising beneficial role of these subsets in the PTC behavior [ 125 ].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, Pan and colleagues [ 125 ] recently investigated by single-cell RNA sequencing an enrichment pattern of TIBs in PTC tumor tissues that were concurrent with thyroiditis, but not in the PTC alone/without thyroiditis. They confirmed the indolent property of PTC when it is associated with a pre-existing thyroiditis explained by the expansion of this distinct signature of B cells [ 54 ].…”

Section: Adaptive and Innate Immune Response Surrounding Ptc In The C...mentioning

confidence: 99%

“…More importantly, Pan et al [ 125 ] constructed the single-cell transcriptome landscape of PTC and delineated, for the first time, a distinct transcriptional state of PTC with and without thyroiditis. Authors demonstrated that the presence of BRAFV600E positive tumor cells and high expression of different genes (such as TACSTD2, CLDN3, CTSC, and B2M) correlate with disease-free survival and metastatic lymph nodes.…”

Section: Adaptive and Innate Immune Response Surrounding Ptc In The C...mentioning

confidence: 99%

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The Immune Landscape of Papillary Thyroid Cancer in the Context of Autoimmune Thyroiditis

Pani

Caria

Yasuda

et al. 2022

Cancers

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Papillary thyroid cancer (PTC) often co-occurs with Hashimoto’s thyroiditis, an association that has long been reported in clinical studies, remaining controversial. Experimental evidence has recently shown that pre-existing thyroiditis has a beneficial effect on PTC growth and progression by a distinctive expansion of effector memory CD8 T cells. Although the link between inflammation and PTC might involve different components of the immune system, a deep characterization of them which includes T cells, B cells and tertiary lymphoid structures, Mye-loid cells, Neutrophils, NK cells and dendritic cells will be desirable. The present review article considers the role of the adaptive and innate immune response surrounding PTC in the context of Hashimoto’s thyroiditis. This review will focus on the current knowledge by in vivo and in vitro studies specifically performed on animals’ models; thyroid cancer cells and human samples including (i) the dual role of tumor-infiltrating lymphocytes; (ii) the emerging role of B cells and tertiary lymphoid structures; (iii) the role of myeloid cells, dendritic cells, and natural killer cells; (iv) the current knowledge of the molecular biomarkers implicated in the complex link between thyroiditis and PTC and the potential implication of cancer immunotherapy in PTC patients in the context of thyroiditis.

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Section: Discussionmentioning

confidence: 99%

Section: Adaptive and Innate Immune Response Surrounding Ptc In The C...mentioning

confidence: 99%

Section: Adaptive and Innate Immune Response Surrounding Ptc In The C...mentioning

confidence: 99%

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The Immune Landscape of Papillary Thyroid Cancer in the Context of Autoimmune Thyroiditis

Pani

Caria

Yasuda

et al. 2022

Cancers

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“…These further suggests that the immune response may play an important role in the different clinical characteristics between patients with PTC/HT(+) and PTC/HT(-), possibly through the intratumoral mononuclear cell infiltration, then sustained by a significant expansion of regulatory T lymphocytes. Afterwards, the reason for the better prognosis of PTC patients with concurrent HT maybe due to B lymphocyte–related immune response ( 27 ). Unfortunately, the sample size in this study is too small (only 3 cases of PTC/HT(+)), which cannot fully explain the problem, more samples are needed in the future.…”

Section: Discussionmentioning

confidence: 99%

Identification of Long Noncoding RNAs Associated With the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated With Hashimoto’s Thyroiditis

Ding

Peng

et al. 2022

Front. Oncol.

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Long noncoding RNAs (lncRNAs) play a significant role in cancer biology. This study aimed to determine the roles of lncRNAs in establishing the differences in clinical features between patients with papillary thyroid carcinoma (PTC) without Hashimoto’s thyroiditis (HT) and patients with PTC and HT. In the present study, we detected the differentially expressed lncRNAs between tumor tissues of patients with PTC with or without HT through lncRNA microarrays. The data were verified and analyzed through qRT-PCR, cell viability, cell cycle and bioinformatics analyses. We found that 1031 lncRNAs and 1338 mRNAs were abnormally expressed in 5 tissue samples of PTC complicated with HT [PTC/HT (+)] compared with 5 samples of PTC without HT [PTC/HT (-)]. Gene Ontology and pathway analyses of the mRNAs suggested that several biological processes and pathways, particularly immune system processes, were induced in the PTC/HT (+) tissues. Twenty lncRNAs were verified in 31 PTC/HT (+) and 64 PTC/HT (-) specimens by qRT-PCR, and the results were consistent with the microarray data. Specifically, ENST00000452578, a downregulated lncRNA in PTC/HT(+), was negatively correlated with the tumor size. Cell viability assays revealed that ENST00000452578 could inhibit cell proliferation. Our results indicate that lncRNAs and mRNAs play an important role in establishing the different clinical characteristics between patients with PTC/HT(+) and patients with PTC/HT(-), and might provide new insights from the perspective of RNA for obtaining a further understanding of the clinical features related to PTC with HT.

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“…The histological characteristics of HT are lymphocyte infiltration and lymphoid follicle destruction. At present, HT is considered to be closely related to the occurrence of thyroid papillary carcinoma (5)(6)(7). The typical sonogram of HT shows diffuse changes.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic value of a dynamic artificial intelligence ultrasonic intelligent auxiliary diagnosis system for benign and malignant thyroid nodules in patients with Hashimoto thyroiditis

Wang¹,

Zheng²,

Zhang³

et al. 2023

Quant Imaging Med Surg

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Background: A dynamic artificial intelligence (AI) ultrasonic intelligent assistant diagnosis system (dynamic AI) is a joint application of AI technology and medical imaging, which can conduct real-time synchronous dynamic analysis of nodules from multiple sectional views with different angles. This study explored the diagnostic value of dynamic AI for benign and malignant thyroid nodules in patients with Hashimoto thyroiditis (HT) and its significance in guiding surgical treatment strategies.Methods: Data of 487 patients (154 with and 333 without HT) with 829 thyroid nodules who underwent surgery were collected. Differentiation of benign and malignant nodules was performed using dynamic AI, and diagnostic effects (specificity, sensitivity, negative predictive value, positive predictive value, accuracy, misdiagnosis rate and missed diagnosis rate) was assessed. Differences in diagnostic efficacy were compared among AI, preoperative ultrasound based on the American College of Radiology (ACR) Thyroid Imaging Reporting and Data System (TI-RADS), and fine needle aspiration cytology (FNAC) diagnoses. Results:The accuracy, specificity and sensitivity of dynamic AI reached 88.06%, 80.19%, and 90.68%, respectively; besides, there was consistency with postoperative pathological consequences (κ=0.690; P<0.001).The diagnostic efficacy of dynamic AI was equivalent between patients with and without HT, and there were no significant differences in sensitivity, specificity, accuracy, positive predictive value, negative predictive value, missed diagnosis rate, and misdiagnosis rate. In patients with HT, dynamic AI had significantly higher specificity and a lower misdiagnosis rate than did preoperative ultrasound based on the ACR TI-RADS (P<0.05). Compared with FNAC diagnosis, dynamic AI had a significantly higher sensitivity and a lower missed diagnosis rate (P<0.05).Conclusions: Dynamic AI possessed an elevated diagnostic worth of malignant and benign thyroid nodules in patients with HT, which can provide a new method and valuable information for the diagnosis and development of management strategy of patients.

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Papillary Thyroid Carcinoma Landscape and Its Immunological Link With Hashimoto Thyroiditis at Single-Cell Resolution

Cited by 26 publications

References 68 publications

The Immune Landscape of Papillary Thyroid Cancer in the Context of Autoimmune Thyroiditis

The Immune Landscape of Papillary Thyroid Cancer in the Context of Autoimmune Thyroiditis

Identification of Long Noncoding RNAs Associated With the Clinicopathological Features of Papillary Thyroid Carcinoma Complicated With Hashimoto’s Thyroiditis

Diagnostic value of a dynamic artificial intelligence ultrasonic intelligent auxiliary diagnosis system for benign and malignant thyroid nodules in patients with Hashimoto thyroiditis

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