Papillary thyroid cancer associated with syndrome of inappropriate antidiuresis: a case report

Abstract

IntroductionThe syndrome of inappropriate antidiuresis is the most common cause of euvolemic hypo-osmolality. This syndrome is associated with a wide variety of diseases. However, its most frequent causes are related to malignancies, especially lung cancer. In this case report, we describe an unknown association of the syndrome of inappropriate antidiuresis with papillary thyroid cancer.Case presentationWe present the case of a 71-year-old Caucasian, German woman with marked hyponatremia and neurological symptoms. After a detailed clinical investigation, the common causes of syndrome of inappropriate antidiuresis and other malignancies were ruled out. A thyroid nodule was detected by ultrasound and magnetic resonance imaging. Although fine needle aspiration cytology showed negative results, our patient underwent surgery. Papillary thyroid cancer was later diagnosed. After total thyroidectomy, a complete remission of the clinical symptoms occurred and our patient subsequently had iodine-131 radioactive therapy. Hyponatremia was no longer observed during the follow-up investigations.ConclusionThis is the first reported case of paraneoplastic syndrome of inappropriate antidiuresis caused by papillary thyroid carcinoma. Since its symptoms occurred before the development of local symptoms, total thyroidectomy may provide a timely and efficient treatment for the underlying malignancy.

Thyroid carcinoma producing β‐human chorionic gonadotropin shows different clinical behavior

“…Atrophoderma 1 27 Polymyositis 1 28 Dermatomyositis 8 [29][30][31][32][33] Perforating collagenosis 1 34 Myelopathy 1 35 Ectopic hCG secretion 2 24, this case Ectopic parathyroid hormone secretion 1 36 Panuveitis 1 37 Syndrome of inappropriate antidiuresis 1 38 Cerebellar syndrome and sensory ganglionopathy 1 39 Epidermolysis Bullosa Acquisita 1 40 Propriospinal myoclonus 1 41 Systemic lupus erythematosus 1 42 Polymyalgia rheumatica 1 43 Retinopathy 1 44 Neutrophilia & eosinophilia due to granulocyte-macrophage colony-stimulating factor 1 45 FTC Leukocytosis 1 46 Hypertrophic osteoarthropathy 1 47 ATC Ectopic hCG secretion 5 5 Hypertrophic osteoarthropathy 1 48…”

77-jährige Patientin mit Hyponatriämie, Pruritus und papulösem Exanthem

“…Die paraneoplastische Genese eines SIADH ist in der Literatur gut beschrieben und kommt vor allem bei Kopf-Hals-Tumoren und beim kleinzelligen Bronchialkarzinom vor, ist aber grundsätzlich bei sehr vielen Tumorentitäten beschrieben, so auch bei Lymphomen [11,12]. In diesem Fall zeigte sich laborchemisch eine Hyponatriämie infolge eines paraneoplastisch bedingten SIADH sowie eine Paraneoplasie der Haut in Form eines schweren, generalisierten, papulo-pustulösen Exanthems mit massivem, therapie-resistentem Pruritus.…”

Diffuse Toxic Goiter and Coexisting Hurthle Cell Carcinoma of Thyroid Presenting as Mononeuritis Multiplex

“…In a study of 28 patients with Hurthle cell neoplasms of which 19 were malignant, and having distant metastasis during presentation, no paraneoplastic manifestations were described [9]. A case report by Bier et al reported a 71 year old woman with papillary carcinoma of thyroid presenting with SIADH [10]. Kalliabakos reported 31 year old patient who presented with polymyositis along with papillary carcinoma of thyroid [11].…”