Papillary Squamous Cell Carcinoma of the Uterine Cervix: Report of a Case with HPV 16 DNA and Brief Review

Papillary Squamous Cell Carcinoma of the Uterine Cervix, High-Risk Human Papilloma Virus Infection and p16INK4a Expression

“…Because this is a relatively aggressive tumor, it should be diagnosed as soon as possible. [1][2][3]5,6,9,11 As observed in this case, the tumor, coinciding with reports in the literature, occurred in the sixth decade of life and quickly progressed to death. Despite the present case having been diagnosed in stage IIB, conventional cytology as well as liquid-based cytology allowed identification of the malignity of this tumor clearly.…”

“…3,4,7 The greatest trap of this tumor is being diagnosed in superficial biopsies as cervical intraepithelial neoplasia grade 3 (HSIL) due to the basaloid characteristics of its cells. Because this is a relatively aggressive tumor, it should be diagnosed as soon as possible.…”

“…Mitoses are frequent, and koilocytosis cannot be observed. 3,4 Not infrequently, the initial diagnosis of in situ carcinoma is made on the basis of a biopsy that is superficial because of the fear of causing bleeding, with cuts that do not demonstrate the papillary characteristic of the lesion. Only after a deeper second biopsy can the diagnosis be confirmed.…”

Carcinoma Papilar De Células Escamotransicionales Del Cérvix: Presentación De 16 Casos Y Revisión De La Literatura

“…En 1995, un grupo de tumores cervicales con características agresivas similares fue designado con el nombre de tumores de células transicionales por Albores Saavedra y Young, en base a sus características histológicas similares con tumores uroteliales de la vejiga (12). En las series de casos informadas posteriormente, existió una gran controversia en cuanto a la relación exacta entre el carcinoma papilar escamoso y el carcinoma de células transicionales del cérvix, utilizándose en algunos casos indistintamente (17). No estaba claro si los carcinomas papilares del cérvix representaban dos grupos de tumores clíni-co-patológicamente distintos o si se trataba de una sola entidad patológica.…”

Cytologic Diagnosis of Vaginal Papillary Squamotransitional Cell Carcinoma

“…5,[9][10][11]13 These tumors have also been observed in the vagina, usually following a history of papillary transitional cell carcinoma of the urinary tract. [2][3][4]15 There has been only one reported case of a vaginal tumor with this morphology without a preceding urothelial neoplasm.…”