Papillary squamous cell carcinoma of the uterine cervix: an immunophenotypic appraisal of 12 cases

Mirhashemi, Ramin; Ganjei‐Azar, Parvin; Nadji, Mehrdad; Lambrou, Nicholas C; Atamdede, Fikret; Averette, Hervy E.

doi:10.1016/s0090-8258(03)00329-9

Cited by 36 publications

(50 citation statements)

References 13 publications

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“…[5] As PSTCC are typically recognized due to its distinctive pattern of papillary growth pattern, these tumors should be segregated from transitional cell carcinoma, squamous papilloma, verrucous carcinoma, papillary serous adenocarcinoma, and cervical intraepithelial neoplasia especially grade III with papillary features. [1,6] Papillary squamo-transitional cell carcinoma can show variety of spectrum such as pure squamous, pure transitional and mixture of both. [7] It shows papillary architecture with fibrovascular cores lined by multi-layered atypical epithelium and is known for local recurrence and late metastasis.…”

Section: Introductionmentioning

confidence: 99%

Papillary Squamotransitional Cell Carcinoma Cervix- A Rare Case Report

Kaur¹,

Goyal²,

Dass³

et al. 2017

AIMDR

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Papillary squamotransitional cell carcinoma is an uncommon histopathological variant of squamous cell carcinoma of the uterine cervix, which occurs in postmenopausal women. A 45-year-old woman presented in the gynae OPD with history of postmenopausal vaginal bleeding with cauliflower like growth in the cervix .Patient was examined and biopsy was taken from the growth which reveal the diagnosis of papillary transitional cell carcinoma cervix on histopathology.

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Section: Introductionmentioning

confidence: 99%

Papillary Squamotransitional Cell Carcinoma Cervix- A Rare Case Report

Kaur¹,

Goyal²,

Dass³

et al. 2017

AIMDR

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“…3,88 We also found 2 patterns of precursor lesions in the uterine cervix that corresponded to flat and tumoral IN in this organ.…”

Section: Uterine Cervix Intraepithelial Neoplasia Versus Papillary Sqmentioning

confidence: 54%

Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater

Jang

Ahn

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-The identification of a precursor lesion is important to understanding the histopathologic and genetic alterations in carcinogenesis. There are a plethora of terminologies that describe precursor lesions of the pancreatobiliary tract, ampulla of Vater, and gallbladder. The current terminologies for precursor lesions may make it difficult to understand the tumor biology. Here, we propose the concept of tumoral and flat intraepithelial neoplasia to improve our understanding of precursor lesions of many epithelial organs, including the pancreatobiliary tract, ampulla of Vater, and gallbladder.Objective.-To understand the dichotomous pattern of tumoral and flat intraepithelial neoplasia in carcinogenesis of pancreatobiliary tract, ampulla of Vater, and gallbladder.Data Sources.-Review of relevant literatures indexed in PubMed.Conclusions.-Tumoral intraepithelial neoplasia presents as an intraluminal or intraductal, mass-forming, polypoid lesion or a macroscopic, visible, cystic lesion without intracystic papillae. Microscopically, tumoral intraepithelial neoplasia shows various proportions of papillary and tubular architecture, often with a mixed pattern, such as papillary, tubular, and papillary-tubular. The malignant potential depends on the degree of dysplasia and the cell phenotype of the epithelium. Flat intraepithelial neoplasia presents as a flat or superficial, spreading, mucosal lesion that is frequently accompanied by an invasive carcinoma. Tumoral and flat intraepithelial neoplasias are not homogeneous entities and may exhibit histopathologic spectrum changes and different genetic profiles. Although intraepithelial neoplasia showed a dichotomous pattern in the tumoral versus flat types, they can coexist. Tumoral and flat intraepithelial neoplasia can be interpreted as part of a spectrum of changes in the carcinogenesis pathway of each organ. A denoma is the prototype precursor lesion in carcinogenesis. The adenoma-carcinoma sequence is one of the well-characterized models of the carcinogenesis pathway. Through the adenoma-carcinoma sequence, many histopathologic and genetic alterations have been characterized in colorectal carcinogenesis.1,2 Another prototype precursor lesion is uterine cervix dysplasia, which also progresses to invasive squamous cell carcinoma of the uterine cervix through multistep carcinogenesis. Both colon adenoma and uterine cervix dysplasia correspond to intraepithelial neoplasia (IN), which can lead to invasive carcinoma. Most colorectal adenomas present as a polypoid lesion, whereas uterine cervix dysplasia presents as a nonpolypoid, flat, mucosal lesion. We think colon adenoma and uterine cervix dysplasia represent a mass-forming tumoral IN and a nonmass-forming, flat IN, respectively. In general, tumoral IN corresponds to a macroscopic or mass-forming lesion, and flat IN presents as invisible or microscopic lesions. Flat adenomas have been reported in the colorectum, which is much closer to a flat IN, and papillary squamous cell carcinoma of the uterine cervix, which is...

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“…Aunque han sido identifi cadas numerosas cepas de este virus, solo unas pocas están fuertemente asociadas con el desarrollo del carcinoma cervical. A estas se les denominan cepas de alto riesgo e incluyen principalmente HPV 16,18, 31,33 y 35 (40).…”

Section: Discussionunclassified

“…Esto permitió concluir el infrecuente compromiso del cromosoma 9 en los carcinomas de célu-las transicionales del cérvix, junto con la pérdida del alelo concurrente en el cromosoma 3p y las secuencias de HPV 16 existiendo una relación histogené-tica más cercana con los carcinomas de células escamosas del cuello uterino que con el carcinoma urotelial del tracto urinario (46). Finalmente, se han demostrado mutaciones del gen p53 en 3 tumores papilares escamosos del cérvix (40).…”

Section: Discussionunclassified

Carcinoma Papilar De Células Escamotransicionales Del Cérvix: Presentación De 16 Casos Y Revisión De La Literatura

Patiño³

et al. 2009

Rev. chil. obstet. ginecol.

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RESUMENEl carcinoma papilar de células escamotransicionales del cuello uterino, es una variante rara del carcinoma escamoso, que se caracteriza por presentar un patrón arquitectural papilar, por ser profundamente invasivo y por su tendencia a recidivar y metastatizar tardíamente. Se presenta una serie de 16 casos y se analizan los hallazgos clínicos, macroscópicos, histopatológicos, citológicos e inmuno-histoquímicos. Se revisa la literatura, discutiendo la posible génesis de este proceso neoplásico. PALABRAS CLAVE: Carcinoma escamotransicional, carcinoma papilar escamoso SUMMARYPapillary squamous-transitional cell carcinoma of the uterine cervix is a rare variant of squamous cell carcinoma. It is characterized by their papilar architectural pattern, to be deeply invasive, and their tendency to show a late metastasize and local recurrence. A series of 16 cases is presented and their clinical, macroscopic, histopathological, cytologic and immunohistochemical fi ndings are analyzed. The literature is reviewed and the possible genesis of this neoplasm is discussed. KEY WORDS: Squamotransitional carcinoma, papillary squamous carcinoma INTRODUCCIÓNEl cáncer de cuello uterino fue y continua siendo actualmente un factor preponderante de morbimortalidad a nivel mundial, constituyendo una de las principales causas de muerte entre las mujeres en todo el mundo. La mayor incidencia y mortalidad se presenta en países en vía de desarrollo, alcanzando en América Latina y el Caribe cerca de 37.600 decesos anuales (1). Es evidente que este proceso representa un problema relevante de salud públi-ca en Latinoamérica, pudiéndose prevenir y curar cuando se realiza una detección precoz y oportuna de sus lesiones precursoras o del mismo cáncer, de ahí la importancia de un buen diagnostico, tratamiento y seguimiento (2).

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Papillary squamous cell carcinoma of the uterine cervix: an immunophenotypic appraisal of 12 cases

Cited by 36 publications

References 13 publications

Papillary Squamotransitional Cell Carcinoma Cervix- A Rare Case Report

Papillary Squamotransitional Cell Carcinoma Cervix- A Rare Case Report

Tumoral Versus Flat Intraepithelial Neoplasia of Pancreatobiliary Tract, Gallbladder, and Ampulla of Vater

Carcinoma Papilar De Células Escamotransicionales Del Cérvix: Presentación De 16 Casos Y Revisión De La Literatura

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