Papillary Serous and Clear Cell Type Lead to Poor Prognosis of Endometrial Carcinoma in Black Women

Matthews, Roland; Hutchinson-Colas, Juana; Maiman, Mitchell; Fruchter, Rachel G.; Gates, E. Jason; Gibbon, Darlene; Remy, Jean; Sedlis, Alexander

doi:10.1006/gyno.1997.4617

Cited by 106 publications

(54 citation statements)

References 17 publications

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“…Women with UPSC and/or CC have been described as type II corpus cancers that are associated with older age (Bokhman, 1983). Although prior reports have consistently demonstrated older age in patients with UPSC and CC compared to endometrioid uterine cancers, this current study is one of first series with sufficient numbers of patients to show a statistically significant increase in age between the highrisk histologies (Abeler and Kjorstad, 1991;Carcangiu and Chambers, 1995;Matthews et al, 1997). In this current series, the percent of patients with disease spread beyond the uterus (stage II -IV) at the time of diagnosis was 64, 50, and 40% for UPSC, CC, and G3EC, respectively (Po0.001).…”

Section: Discussionmentioning

confidence: 78%

Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers

Cheung²,

et al. 2006

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To compare the survival of women with uterine papillary serous carcinoma (UPSC) and clear cell carcinoma (CC) to those with grade 3 endometrioid uterine carcinoma (G3EC). Demographic, pathologic, treatment, and survival information were obtained from the Surveillance, Epidemiology, and End Results Program from 1988 to 2001. Data were analysed using Kaplan -Meier and Cox proportional hazards regression methods. Of 4180 women, 1473 had UPSC, 391 had CC, and 2316 had G3EC cancers. Uterine papillary serous carcinoma and CC patients were older (median age: 70 years and 68 vs 66 years, respectively; Po0.0001) and more likely to be black compared to G3EC (15 and 12% vs 7%; Po0.0001). A higher proportion of UPSC and CC patients had stage III -IV disease compared to G3EC patients (52 and 36% vs 29%; Po0.0001). Uterine papillary serous carcinoma, CC and G3EC patients represent 10, 3, and 15% of endometrial cancers but account for 39, 8, and 27% of cancer deaths, respectively. The 5-year disease-specific survivals for women with UPSC, CC and G3EC were 55, 68, and 77%, respectively (Po0.0001). The survival differences between UPSC, CC and G3EC persist after controlling for stage I -II (74, 82, and 86%; Po0.0001) and stage III -IV disease (33, 40, and 54; Po0.0001). On multivariate analysis, more favourable histology (G3EC), younger age, and earlier stage were independent predictors of improved survival. Women with UPSC and CC of the uterus have a significantly poorer prognosis compared to those with G3EC. These findings should be considered in the counselling, treating and designing of future trials for these high-risk patients.

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Section: Discussionmentioning

confidence: 78%

Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers

Cheung²,

et al. 2006

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“…Conclusions regarding the relative contributions of clinical and biologic factors to the less favorable outcome experienced by blacks vary. [5][6][7][8][9][10][11][12][13][14][15] Although several studies have found that the symptomatic period before presentation or treatment is similar for blacks and whites, 10,12,20 additional studies evaluating possible racial disparities in health care access, diagnosis, and treatment are needed.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,4 The higher incidence of endometrioid adenocarcinoma among whites compared with blacks accounts for the higher overall incidence of endometrial carcinoma among whites. Data demonstrating that blacks tend to present with more advanced-stage disease [5][6][7][8][9][10][11][12][13][14] and receive less aggressive treatment 8 than do whites suggest that providing blacks with improved health care could reduce their endometrial cancer mortality. Nonetheless, worse survival for blacks with readily curable forms of endometrial carcinoma may not account entirely for the racial disparity in mortality.…”

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confidence: 99%

“…[7][8][9][10][11][12]15,16 Studies also suggest that the etiology and pathogenesis of some aggressive types of endometrial carcinoma differ from those of the most common type of endometrial carcinoma, endometrioid adenocarcinoma. 4,17 Specifically, pure serous carcinoma appears to develop from atrophic, rather than hyperplastic, epithelium and may not be associated with typical risk factors for endometrial malignancy.…”

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confidence: 99%

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Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus

Sherman

Devesa

2003

Cancer

196

107

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Population balance models (PBMs) are widely used to describe the dynamics of particulate systems. The simulation of PBMs becomes challenging with increasing numbers of dimensions and integral terms associated with phenomena, such as coalescence and breakage, which has motivated efforts to develop more computationally efficient numerical algorithms. This article presents high‐resolution finite‐volume methods for the parallel simulation of PBMs that scale well to ∼100 processors on a linux cluster. The high‐resolution methods provide second‐order accuracy with an accurate tracking of sharp fronts. The ParticleSolver software implementing these methods is verified by application to PBMs for (1) aerosol coagulation and condensation, (2) the formation of gold nanoparticles by nucleation, disproportionation, and coagulation, and (3) the nucleation and growth of inorganic crystals with a time‐varying shape distribution. © 2008 American Institute of Chemical Engineers AIChE J, 2008

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“…1 It is a very aggressive tumor, unrelated to estrogen stimulation, arising occasionally in endometrial polyps or from precancerous lesions developing in atrophic endometrium that mainly occur in older women. 2 Patients with SC are at median of 5-10 years older than those with endometrioid carcinomas of the endometrium (EEC). SCs have also been reported in association with a history of breast cancer.…”

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confidence: 99%

Practical issues in the diagnosis of serous carcinoma of the endometrium

Gatius

Matías‐Guiu

2016

Modern Pathology

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Papillary Serous and Clear Cell Type Lead to Poor Prognosis of Endometrial Carcinoma in Black Women

Cited by 106 publications

References 17 publications

Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers

Uterine papillary serous and clear cell carcinomas predict for poorer survival compared to grade 3 endometrioid corpus cancers

Analysis of racial differences in incidence, survival, and mortality for malignant tumors of the uterine corpus

Practical issues in the diagnosis of serous carcinoma of the endometrium

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