Papillary Lesions of the Breast: A Practical Approach to Diagnosis

Jorns, Julie M.

doi:10.5858/arpa.2016-0219-ra

Cited by 24 publications

(18 citation statements)

References 22 publications

(20 reference statements)

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“…According to the WHO breast tumor classification [22], the pathology of papillary carcinoma of the breast is divided into intraductal papilloma with atypical ductal hyperplasia or DCIS, intraductal papillary carcinoma, coated papillary carcinoma or with infiltration, and solid papillary carcinoma or infiltration. Papillary carcinoma is rare, whose incidence is 0.5% to 1.0% in breast cancer, however, it is more common in postmenopausal women and older women with favorable prognosis [2][3][4]. This patient is a 63-year-old woman who was admitted with a painful, greater than 15 cm mass in her right breast.…”

Section: Discussionmentioning

confidence: 99%

“…Breast cancer is the most commonly diagnosed cancer (11.6%) and the leading cause of cancer death (6.6%) among females globally [1]. Papillary lesions of the breast initiate within the ducto-lobular system supported by fibrovascular cores, and comprise a heterogeneous group of neoplasms, including (a) intraductal papilloma, (b) papilloma with atypical ductal hyperplasia, (c) papilloma with ductal carcinoma in situ, and (d) papillary carcinoma [2,3]. Papillary carcinoma is an uncommon type of breast cancers with a better prognosis, accounting for 0.5-1% of breast cancers, and contains encapsulated and solid types [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model

Pan

Song

et al. 2020

Cancer Cell Int

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Background: Papillary carcinoma is an uncommon type of breast cancer. Additionally, patients with huge breast papillary carcinoma are extremely rare in clinical practice. To improve therapeutic effect on such patients, it is urgent to explore biologically and clinically relevant models of the disease to discover effective drugs. Methods: We collected surgical tumor specimens from a 63-year-old Chinese woman who has been diagnosed breast papillary carcinoma. The tumor was more than 15 cm in diameter, and applied to establish patient-derived papillary carcinoma organoids that could continuously propagate for more than 6 months. Results: The papillary carcinoma organoids matched the histological characteristics of orginal tumor by H&E staining identification, and maintained the expression of the breast cancer biomarkers by IHC, including estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor (HER2) and antigen Ki-67 (Ki67). In addition, we performed a 3-D drug screening to examine the effects of endocrine drugs (Fulvestrant, Tamoxifen) and targeted therapy drugs (Palbociclib, Everolimus, BKM120) on breast papillary carcinoma in the mimic in vivo environment. The drug sensitivities of our breast papillary carcinoma organoids were investigated as follows, Fulvestrant (IC 50 0.275 μmol), Palbociclib (IC 50 2.21 μmol), BKM120 (IC 50 3.81 μmol), Everolimus (IC 50 4.45 μmol), Tamoxifen (IC 50 19.13 μmol). Conclusions: These results showed that an effective organoid platform for 3-D in vitro culture of breast cancer organoids from patients with breast papillary carcinoma could be used to identify possible treatments, and might be commonly applied to explore clinicopathological characteristics of breast papillary carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model

Pan

Song

et al. 2020

Cancer Cell Int

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“…As an invasive component of PC significantly influences the axillary LN status, accurate identification of invasive tumours at preoperative histology is a crucial stage where patients could be stratified for SLNB . However, this is dependent on the accuracy of preoperative histological examination . When questioning the need for SLNB most pertinent are cases of encysted PC and solid PC where there is expansion and architectural complexity to a point that invasion is being considered.…”

Section: Discussionmentioning

confidence: 99%

Papillary breast cancer: A retrospective single‐centre clinical study

2020

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Papillary carcinoma (PC) of the breast is a rare malignancy that accounts for 0.5%‐1% of breast cancers. PC remains an understudied cancer, and we still require further information on its behaviour, staging and management. In particular, a significant proportion of PC cases still undergo sentinel lymph node biopsy without clear empirical justification. In the present study, we provide a valuable cohort of 44 PC patients and examine the clinicopathological features and outcome of loco‐regional staging. Our results provide important insights into the behaviour of PC and suggest SLNB may be spared in this condition. Crucially, we show only one histologically confirmed PC case had evidence of nodal metastasis. In addition, up to 5 years postsurgery, no patient in our cohort died from their cancer. Together, our results support further work in the utility of SLNB in PC and highlight the favourable prognosis of this tumour. We propose SLNB should not be routinely indicated for patients with PC treated with breast conservation, and future studies should aim to incorporate prospective data to help inform optimal management of PC.

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“…The final decision is critical because it is essential for subsequent patient's management. In borderline lesions, the distinction between benign and malignant components is challenging needing communitive evidence [7] [8]. Presence of connective tissue fibers including collagen, elastic and reticular fibers is well documented with breast lesions [9].…”

Section: Introductionmentioning

confidence: 99%

A Correlation between Histochemical Patterns of Connective Tissue Fibers and AgNORs in Breast Lesions

Elasbali¹

2019

OJPathology

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Background: The precise histopathologic diagnosis of a breast lesion is the first step towards the most appropriate inclusive patient's management. The aim of this study was to evaluate the correlation between histochemical patterns of connective tissue fibers and NORs in breast lesions. Methodology: Patients with breast cancer (n = 25) were ascertained as the case group, and those with benign breast lesions were ascertained as a control group (n = 25). Histochemical evaluations of elastic fibers, reticular fibers and mean AgNORs count were performed for all study subjects. Results: Elastic fibers intensity was brought into being lessening in benign lesions and upturns in the direction of malignant lesions. The intensity of elastic fibers was found to intensify with rises of neoplastic changes in breast cancer and this was found to be statistically significant P < 0.001. Mean AgNORs counts displayed increased clusters among malignant cases equated to benign ones. Mean AgNORs count significantly increased with neoplastic proliferation P < 0.005. Conclusion: Demonstration of connective tissue fibers (particularly elastic fibers) can strength the diagnostic evidence for conventional histopathology diagnosis. Mean AgNORs count can merge as an important quantitative marker in breast cancer diagnosis.

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Papillary Lesions of the Breast: A Practical Approach to Diagnosis

Cited by 24 publications

References 22 publications

Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model

Breast cancer organoids from a patient with giant papillary carcinoma as a high-fidelity model

Papillary breast cancer: A retrospective single‐centre clinical study

A Correlation between Histochemical Patterns of Connective Tissue Fibers and AgNORs in Breast Lesions

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