Papillary haemangioma in the spinal canal of a patient with a germline 12p microdeletion

Ono, Yuho; Goldsmith, Jeffrey D.; Hsu, Nancy; Bryke, Christine R.; Varma, Hemant

doi:10.1111/his.13861

Cited by 4 publications

(8 citation statements)

References 4 publications

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“…4 Though most lesions are cutaneous and found in the head and neck region, there has been one reported case of PH arising from the spinal cord. 5 Our case of PH is the rst intraosseous and second non-cutaneous lesion to be reported.…”

Section: Discussionmentioning

confidence: 81%

A Rare Case of Intraosseous Papillary Hemangioma of the Head and Neck

Geetha

Abdelwahed

Edelman

et al. 2023

Preprint

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Objectives Papillary hemangioma (PH) is a novel variant of intravascular capillary hemangioma. It is more common in adults and has a male predominance. Most tumors reported so far are solitary and cutaneous. Here we present a rare case of an intraosseous PH involving the frontal bone. Methods Brain imaging in a 69-year-old male with a slowly enlarging swelling on the right frontal area following an accidental fall demonstrated a 4.5 cm x 1.7 cm x 4.2 cm mass originating from the right frontal bone, with a tiny defect on the orbital roof. A malignant process was favored, and the mass was removed. Results Histopathology revealed a vascular lesion showing intraosseous distribution with foci of extension into the fibrous connective tissue. There were areas of plump endothelial cells with intracytoplasmic hyaline globules arranged in papillary configuration. The lesional cells were immunoreactive with CD34 and vimentin. AE1/AE3, EMA, PR, D2-40, inhibin and S100 stains were negative. Ki-67 was low. Conclusion This is the first intraosseous and second non-cutaneous PH. Clinically it differs from other cases by the presence of trauma as a preceding event. Since its prognosis is unknown such patients should be monitored for recurrence or malignant transformation.

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Section: Discussionmentioning

confidence: 81%

A Rare Case of Intraosseous Papillary Hemangioma of the Head and Neck

Geetha

Abdelwahed

Edelman

et al. 2023

Preprint

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“…1 Since then, an additional five cases of PH have been reported. [2][3][4][5][6] A summary of all previously published cases in the PubMed database, as well as the current case, is listed in Table 1. PH demonstrates a striking predilection for the skin of the head and neck region (16/17 cases, 94%).…”

Section: Discussionmentioning

confidence: 99%

“…One reported case occurred in the spinal canal. 4 It is often solitary, but multiple lesions can occur. 5 A wide age range (range 2-77 years, median 57 years) can be affected with a slight male predilection (10/17, 59%).…”

Section: Discussionmentioning

confidence: 99%

“…1 A total of 16 cases of PH have been documented in the English literature in the PubMed database, with the reported size ranging from 0.03 to 5.0 cm (median 1.1 cm). [1][2][3][4][5][6] Among them, cutaneous PH ranges in size from 0.03 to 1.5 cm (median 0.95 cm). Here, we describe an additional case of cutaneous PH with an exceptionally large size of 10 cm.…”

Section: Introductionmentioning

confidence: 99%

“…The intravascular arrangement of the neoplastic endothelial cells resembles glomeruloid hemangioma (GH), however, unlike GH, clinical signs of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes syndrome) and Castleman disease are absent 1 . A total of 16 cases of PH have been documented in the English literature in the PubMed database, with the reported size ranging from 0.03 to 5.0 cm (median 1.1 cm) 1–6 . Among them, cutaneous PH ranges in size from 0.03 to 1.5 cm (median 0.95 cm).…”

Section: Introductionmentioning

confidence: 99%

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Giant papillary hemangioma—A rare tumor with an exceptional size

Abdo,

Dykstra,

Meyer

et al. 2023

J Cutan Pathol

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Papillary hemangioma (PH) is a recently described vascular tumor with a predilection for the skin of the head and neck. Histopathologically, it is characterized by a bland endothelial proliferation arranged in a papillary configuration, bearing resemblance to glomeruloid hemangioma seen in the context of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes syndrome. The largest cutaneous PH reported to date measured 1.5 cm in greatest dimension. Here, we report a case of PH with an alarming size of 10 cm. We present this case to add to the limited literature on this rare tumor, highlight the histopathologic differences between PH and its mimics, and emphasize the variable nature of PH tumor size.

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Papillary Hemangioma: An Under-Recognized Entity Not to Be Confused With Glomeruloid Hemangioma

Maloney

Miller

Linos

2020

The American Journal of Dermatopathology

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Papillary hemangioma is a recently described benign hemangioma that typically presents on the head and neck of otherwise healthy individuals. It comprises branching papillary structures that protrude into the lumen of ectatic thin-walled vessels. Glomeruloid hemangioma (GH) is a similar, but unique, entity that occurs in patients with POEMS syndrome. The additional clinical implications of GH make distinction from papillary hemangioma critical. An additional case is herein presented and the literature on the subject reviewed. Potential differential diagnoses are discussed, with particular emphasis on the distinction from GH.

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Papillary haemangioma in the spinal canal of a patient with a germline 12p microdeletion

Cited by 4 publications

References 4 publications

A Rare Case of Intraosseous Papillary Hemangioma of the Head and Neck

A Rare Case of Intraosseous Papillary Hemangioma of the Head and Neck

Giant papillary hemangioma—A rare tumor with an exceptional size

Papillary Hemangioma: An Under-Recognized Entity Not to Be Confused With Glomeruloid Hemangioma

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