Papillary glioneuronal tumors: A radiopathologic correlation

Yadav, Nishtha; Rao, Shilpa; Saini, Jitender; Prasad, Chandrajit; Mahadevan, Anita; Sadashiva, Nishanth

doi:10.1016/j.ejrad.2017.10.004

Cited by 17 publications

(13 citation statements)

References 25 publications

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“…Although calcifications can be seen within tumor, intra-tumoral hemorrhage is an extremely rare radiological presentation of these tumors [6,42]. Hemorrhage in form of chronic microhemorrhages leading to hemosiderosis is rarely reported [43,5] but we believe that this is the second report of an acute intratumoral hemorrhage in these tumors. So, here we present the first report of PGNT in a toddler with extremely rare acute hemorrhagic presentation leading to focal neurological deficit which was diagnosed and surgically treated with favorable outcomes.…”

Section: Background and Importancementioning

confidence: 70%

“…Only 150 cases of PGNTs are reported up to now in the literature [36,31,17,11,41,15,12,2]. Amongst these, only 41 cases are reported in pediatric population which demonstrates rarity of this pathology in this age group [11,43,44,32,35,29,26,8,1,42,30,33,28,34,20,18,19,14,16,3,39,13,10,38,7,25,9,4,23]. To our 3 knowledge, there is no report of PGNT in a toddler up to now.…”

Section: Background and Importancementioning

confidence: 94%

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Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Tavallaii

Keykhosravi

Rezaee

2020

British Journal of Neurosurgery

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Background and Importance: Papillary glioneuronal tumor is a recently known entity in central nervous system tumors. These benign WHO grade I tumors are mostly seen in young adults. Pediatric PGNT is rare and there is no report of these tumors in toddlers. Headache, nausea/vomiting and seizure are most common clinical symptoms. Acute presentation with focal neurological deficits or loss of consciousness are not amongst the expected presentations. These tumors are typically cystic with enhancing mural nodule. Although case with chronic intermittent microhemorrhages are reported in the literature but overt intra-tumoral hemorrhage is an odd radiological presentation with just one reported case in the literature. Clinical presentation: We present an extremely rare case of PGNT presenting with sudden onset hemiparesis and impaired consciousness due to acute intra-tumoral hemorrhage in a toddler which was surgically treated with favorable outcome. Conclusion: PGNTs can also be seen in very young children even in toddlers. Also, it should be kept in mind that these tumors have potential for overt intra-tumoral hemorrhage and acute presentation with focal neurological deficits mimicking more common pathologies which should be considered to plan optimal patient management.

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Section: Background and Importancementioning

confidence: 70%

Section: Background and Importancementioning

confidence: 94%

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Tavallaii

Keykhosravi

Rezaee

2020

British Journal of Neurosurgery

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“…An elevated choline peak is the dominant finding on the MRS [114]. A lactate peak has also been described [114].…”

Section: Papillary Glioneuronal Tumor (Pgnt)mentioning

confidence: 97%

“…PGNT can be purely cystic, a cyst with a mural nodule, a solid cystic tumor, or a completely solid tumor [113]. Intertumoral hemorrhage is common [114]. It is a well-circumscribed tumor and is typically devoid of any peritumoral edema, even when the tumor is very large.…”

Section: Papillary Glioneuronal Tumor (Pgnt)mentioning

confidence: 99%

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Radiohistogenomics of pediatric low-grade neuroepithelial tumors

2021

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Purpose In addition to histology, genetic alteration is now required to classify many central nervous system (CNS) tumors according to the most recent World Health Organization CNS tumor classification scheme. Although that is still not the case for classifying pediatric low-grade neuroepithelial tumors (PLGNTs), genetic and molecular features are increasingly being used for making treatment decisions. This approach has become a standard clinical practice in many specialized pediatric cancer centers and will likely be more widely practiced in the near future. This paradigm shift in the management of PLGNTs necessitates better understanding of how genetic alterations influence histology and imaging characteristics of individual PLGNT phenotypes. Methods The complex association of genetic alterations with histology, clinical, and imaging of each phenotype of the extremely heterogeneous PLGNT family has been addressed in a holistic approach in this up-to-date review article. A new imaging stratification scheme has been proposed based on tumor morphology, location, histology, and genetics. Imaging characteristics of each PLGNT entity are also depicted in light of histology and genetics. Conclusion This article reviews the association of specific genetic alteration with location, histology, imaging, and prognosis of a specific tumor of the PLGNT family and how that information can be used for better imaging of these tumors.

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The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 3—Summary of Imaging Findings on Glioneuronal and Neuronal Tumors

Park,

Vollmuth,

Foltyn‐Dumitru

et al. 2023

Magnetic Resonance Imaging

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The fifth edition of the World Health Organization classification of central nervous system tumors published in 2021 reflects the current transitional state between traditional classification system based on histopathology and the state‐of‐the‐art molecular diagnostics. This Part 3 Review focuses on the molecular diagnostics and imaging findings of glioneuronal and neuronal tumors. Histological and molecular features in glioneuronal and neuronal tumors often overlap with pediatric‐type diffuse low‐grade gliomas and circumscribed astrocytic gliomas (discussed in the Part 2 Review). Due to this overlap, in several tumor types of glioneuronal and neuronal tumors the diagnosis may be inconclusive with histopathology and genetic alterations, and imaging features may be helpful to distinguish difficult cases. Thus, it is crucial for radiologists to understand the underlying molecular diagnostics as well as imaging findings for application on clinical practice.Evidence Level3Technical EfficacyStage 3

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Papillary glioneuronal tumors: A radiopathologic correlation

Cited by 17 publications

References 25 publications

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Acute presentation of papillary glioneuronal tumor due to intra-tumoral hemorrhage in a toddler: an odd presentation of a rare pathology

Radiohistogenomics of pediatric low-grade neuroepithelial tumors

The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 3—Summary of Imaging Findings on Glioneuronal and Neuronal Tumors

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