Papillary-cystic neoplasm of the pancreas. Report of two cases and review of the literature

Bombí, J. A.; Millà, A.; Badal, Josep; Piulachs, Jordi; Vila, Jordi; Cardesa, Antonio

doi:10.1002/1097-0142(1984)54:4<780::aid-cncr2820540433>3.0.co;2-4

Cited by 70 publications

(14 citation statements)

References 16 publications

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“…Previously reported ultrastructural findings of rough endoplasmic reticulum, possible pre-zymogen granules, neurosecretory type (endosecretory) granules, rudimentary cell junctions [4,11,15,16], and the generally undifferentiated nature of the cells suggest origin from a multipotential ductular stem cell. Structures called ''large zymogen granules" [ 191 are most likely large lipolysosomes.…”

Section: Distinctive Lamellar Bodies Present In Tumor Cells (Arrowmentioning

confidence: 88%

Papillary‐cystic neoplasm of the pancreas

Pezzi

Schuerch

Erlandson

et al. 1988

Journal of Surgical Oncology

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Papillary-cystic neoplasm of the pancreas is a rare tumor which has recently been described as a distinct, clinicopathological entity. Forty-four previously described cases from the literature and an additional 52 cases referred to in a brief abstract are reviewed. An additional case occurring in a 25-year-old woman is reported. This tumor occurs primarily in young women (mean age 23.3 years) and presents as a large abdominal mass (mean size 10.3 cm) in 63% of patients. Treatment is surgical resection of the involved portions of the pancreas and results of treatment are excellent following this form of therapy alone. The tumor appears to represent a low-grade malignancy, possibly of ductal cell origin. Only two patients with recurrences and two patients with metastatic disease have been reported. Surgeons should be aware of this curable pancreatic malignancy as they are most often responsible for the evaluation and treatment of the patient presenting with a large abdominal mass.

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Section: Distinctive Lamellar Bodies Present In Tumor Cells (Arrowmentioning

confidence: 88%

Papillary‐cystic neoplasm of the pancreas

Pezzi

Schuerch

Erlandson

et al. 1988

Journal of Surgical Oncology

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“…Annulate lamellae were often observed in the tumor cells of p~~.12, 18,24,27,32,35 They are organelles, the origin and function of which have not been clarified, but are considered to be markers for immature or poorly differentiated cells due to their frequent appearance in germ cells, parts of embryonal cells, and neoplasm^.^' From these observations, the histologic origin of PCN is considered to be totipotential immature cells such as those that comprise the pancreatic primordium, developing, in budding form, pancreatic exocrine and endocrine glands during the embryonal development of the pancreas. The concept of PCN as an independent tumor may be supported by its unique clinicopathologic features, but the tumor may be regarded as pancreaticoblastoma with delayed onset due to its histogenesis from totipotential immature cells.…”

Section: Discussionmentioning

confidence: 99%

Papillary-cystic neoplasm of the pancreas. A clinicopathologic study concerning the tumor aging and malignancy of nine cases

Matsunou

Konishi

1990

Cancer

167

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Nine female patients with papillary-cystic neoplasms (PCN) of the pancreas were studied clinicopathologically. The ages of seven of these patients ranged from 8 to 24 years. The remaining two patients, who were 47 and 60 years of age, were considered to have had the onset in their youth. There were few subjective symptoms, and the lesion was most often detected as a palpation of a mass by the patients themselves. Although the prognosis was generally favorable, the two older patients died of metastases. This suggested low-grade malignancy of PCN. The tumors were large (6.9 cm in mean diameter) and encapsulated, and their cross-sections showed an intermingling of solid tumoral areas and cystic necrotic areas. The histologic features of the solid tumoral portion were relatively uniform, with the tumor cells showing solid and pseudopapillary or pseudoglandular proliferation but few mitoses or atypism. Histochemical, immunohistochemical, and electron microscopic examinations showed polymorphic differentiation, which means that part of the tumor cells differentiated into duct epithelium, acinus, and endocrine cells (primary constituents of the pancreas). These findings suggest that the origin of PCN is totipotential primordial cells found in the development of the embryonic pancreas.

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“…Although the pathologic features of SPT have been well described in recent years, its phenotype could not be clearly related to any of the wellcharacterized cells of the pancreas. Some studies indicated an origin from acinar cells [2,18,21,22,23] or endocrine cells [16,43,46], but the results of most other studies have not been compatible with these suggestions [19,28,36]. The immunocytochemical phenotype is characterized by the frequent expression of vimentin, neuron-specific enolase (NSE), and alpha-1-antitrypsin (AAT) [41].…”

Section: Introductionmentioning

confidence: 99%

Solid-pseudopapillary tumor of the pancreas: its origin revisited

Kosmahl¹,

et al. 2000

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Solid-pseudopapillary tumor of the pancreas (SPT) has distinctive morphologic and biologic features but an unclear origin. It is classified among the pancreatic epithelial tumors, though many are reported to be negative for cytokeratin. Also unclear are its neuroendocrine differentiation, its capability to express alpha-1-antitrypsin (AAT) and, in view of the tumor's striking prevalence in women, its relationship with the female genital tract. To clarify these issues, the immunoprofiles of 59 SPTs were defined by applying a battery of antibodies against cytokeratin, vimentin, neuron-specific enolase (NSE), synaptophysin, chromogranin A, tyrosine hydroxylase (TH), AAT, LeuM1, Ki-M1P, smooth-muscle actin, CD34, alpha-inhibin, calretinin, placental alkaline phosphatase (PLAP), and progesterone and estrogen receptors. The most consistent markers with the strongest immunoreactivity were vimentin, AAT, NSE, and the progesterone receptor, which were each found in more than 90% of the tumors. Using immunocytochemical methods involving antigen retrieval, cytokeratin was demonstrated in almost 70% of the cases. Synaptophysin was found in 22% of the tumors, while chromogranin was absent and tyrosine hydroxylase was only present in a few tumors. None of the other markers tested were expressed by SPTs. This staining pattern fails to reveal a clear phenotypic relationship with any of the defined cell lineages of the pancreas. In view of the striking female preponderance of SPTs and the known close approximation of the genital ridges to the pancreatic anlage during embryogenesis, it is, however, hypothesized that SPTs might derive from genital ridge/ovarian anlage-related cells, which were attached to the pancreatic tissue during early embryogenesis.

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Papillary-cystic neoplasm of the pancreas. Report of two cases and review of the literature

Cited by 70 publications

References 16 publications

Papillary‐cystic neoplasm of the pancreas

Papillary‐cystic neoplasm of the pancreas

Papillary-cystic neoplasm of the pancreas. A clinicopathologic study concerning the tumor aging and malignancy of nine cases

Solid-pseudopapillary tumor of the pancreas: its origin revisited

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