Papillary cystadenofibroma of endometrium: A histochemical and ultrastructural study

Grimalt, Miguel; Argüelles, Mario; Ferenczy, Alex

doi:10.1002/1097-0142(197507)36:1<137::aid-cncr2820360110>3.0.co;2-m

Cited by 32 publications

(7 citation statements)

References 4 publications

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“…The intercellular matrix contained large bundles of collagen fibres. The appearances most closely resembled the adenofibroma reported by Grimalt, Arguelles & Ferenczy (1975).…”

Section: Uterine Clear Cell Carcinofibroma 1075supporting

confidence: 69%

Müllerian clear cell carcinofibroma of the uterine corpus

Peters

Wells

1984

Histopathology

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“…The intercellular matrix contained large bundles of collagen fibres. The appearances most closely resembled the adenofibroma reported by Grimalt, Arguelles & Ferenczy (1975).…”

Section: Uterine Clear Cell Carcinofibroma 1075supporting

confidence: 69%

Müllerian clear cell carcinofibroma of the uterine corpus

Peters

Wells

1984

Histopathology

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“…Although such structures probably were described as early as 1917 by Schaffer (1917 who observed them in the human bulbourethral glands and named them "Attraktosomen," it was not until they were studied by electron microscopy in human labial salivary glands that their filamentous nature was revealed (Tandler et al, 1969a). Since then they have been observed in a variety of human mucous glands, principally in the female reproductive tract (Philipp, 1972;Rorat et al, 1975;Grimalt et al, 1975;Ferenczy, 1976) and in a variety of mucus-producing salivary glands (Tandler and Riva, 1986;Shimono et al, 1971) but never in goblet cells. The only nonhuman mammal in which they have been noted is the red-backed vole, where they occur in the submandibular gland (Odajima, 1981).…”

Section: Discussionmentioning

confidence: 99%

Ultrastructural observations on human sublingual gland

1988

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That part of the human sublingual gland that corresponds in morphology to the conventional description of this organ presented in most histology texts (probably the major sublingual gland, in contradistinction to the aggregated small glands that compose the minor sublingual glands) was studied by electron microscopy. The gland is mixed, with slightly more mucous elements than seromucous ones. The mucous cells are arranged in tubules that usually are capped by seromucous demilunes. Seromucous cells also form occasional acini or may be scattered in the walls of the mucous tubules. The appearance of the mucous cells varies with the stage of the secretory cycle that they may be in. Their secretory droplets increase in number and progressively compress cytoplasmic organelles. Filamentous bodies also may be present. Based on secretory-granule substructure, four different kinds of seromucous cells can be recognized; these may be a morphological expression of asynchronous synthesis of different secretory proteins. The duct system is an abbreviated one compared to the other major salivary glands. The first duct segments, into which the mucous tubules drain, are similar to intercalated ducts. Larger ducts contain mitochondria-rich cells but lack the basal striations that characterize striated ducts. The paucity of typical striated ducts may be correlated with the elaboration of sodium-rich saliva by the human sublingual gland.

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“…On many occasions the lesion is diagnosed as a cervical polyp and only after several recurrences is the tumor re‐evaluated and diagnosed as adenosarcoma ( 2 , 15 ) . There is uncertainty in the differential diagnosis from the adenofibroma, a benign tumor of Müllerian origin ( 4 , 18 –20 ) ; recently the diagnosis of Müllerian adenofibroma was restricted to a few cases ( 2 ) ; whereas Müllerian adenosarcoma was diagnosed in tumors with marked cellularity, significant nuclear atypia and more than two mitotic figures per 10 HPF. In our series of 11 cases of Müllerian adenosarcoma, heterologous elements were present in three cases and sarcomatous overgrowth in one case.…”

Section: Discussionmentioning

confidence: 99%

Uterine and extrauterine Mullerian adenosarcoma: a histopathologic and flow cytometric study

Kerner¹,

Levy²,

Friedman³

et al. 1997

Int J Gynecol Cancer

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Uterine adenosarcoma is a rare tumor of Müllerian origin and is characterized by a benign glandular component and a sarcomatous usually low‐grade, stroma, We examined 11 cases of Müllerian adenosarcoma, eight cervical, two uterine and one of the peritoneum. Tissue protruding from the cervix and an initial diagnosis of a cervical polyp were common findings for most patients with uterine adenosarcoma. On repeated examination these cases were re‐evaluated as Müllerian adenosarcomas. Histologic examination revealed benign glands with a sarcomatous stroma, which typically formed periglandular cuffs of increased cellularity. The saromatous stroma was homologous in four cases but contained heterologous elements, such as striated muscle, lipoblasts and cartilage in three cases; in one case a sarcomatous overgrowth of stromal elements was found. The question of a Müllerian adenofibroma vs adenosarcoma was raised in three cases. According to stromal cellularity, stromal atypia and mitotic rate, the cases were classified as adenosarcomas. Sarcomatous overgrowth, presence of heterologous elements and high mitotic rate seem to indicate poor prognosis. Flow cytometry showed a predominantly diploid population of cells in eight cases of adenosarcoma. An aneuploid cell population was seen in three cases of adenosarcoma and in all but one case of carcinosarcoma studied as controls. Gynecologists and pathologists should be aware of the difficulties and delay in the diagnosis of Müllerian adenosarcoma in cases when the tumor presents as a benign looking cervical polyp. Flow cytometric DNA analysis might serve as a useful tool in the diagnosis of Müllerian adenosarcoma vs carcinosarcoma and contribute to the prognostic evaluation in different histologic subsets of the tumor.

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Papillary cystadenofibroma of endometrium: A histochemical and ultrastructural study

Cited by 32 publications

References 4 publications

Müllerian clear cell carcinofibroma of the uterine corpus

Müllerian clear cell carcinofibroma of the uterine corpus

Ultrastructural observations on human sublingual gland

Uterine and extrauterine Mullerian adenosarcoma: a histopathologic and flow cytometric study

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